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WS 12

WS 12 structure

CAS No.: 68489-09-8

Chemical Name:: WS 12

Synonyms: WS 12;AR-15512;Cooler-12;Cooling agent WS12;Cooler than menthol;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide;N- (4- methoxy phenyl) - menthol -3- carboxylase;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12);(2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide;Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)-

CBNumber:: CB02455758

Molecular Formula:: C18H27NO2

Molecular Weight:: 289.41

MDL Number:: MFCD11100191

MOL File:: 68489-09-8.mol

MSDS File:: SDS

Last updated:2024-05-27 17:30:58

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WS 12 Properties

Boiling point	447.8±28.0 °C(Predicted)
Density	1.029±0.06 g/cm3(Predicted)
vapor pressure	0-0Pa at 20-50℃
FEMA	4681 \| (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
storage temp.	-20°C
solubility	DMSO: >20mg/mL
pka	14.18±0.70(Predicted)
form	White to off-white powder.
color	white to off-white
Odor	at 100.00 %. cool minty
Odor Type	minty
JECFA Number	2079
InChIKey	HNSGVPAAXJJOPQ-XOKHGSTOSA-N
LogP	3.95 at 22℃ and pH7.7
Substances Added to Food (formerly EAFUS)	(1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
CAS DataBase Reference	68489-09-8
FDA UNII	1L7BVT4Z4Z

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H410
Precautionary statements	P273-P391-P501
Hazard Codes	N
Risk Statements	50
Safety Statements	53-61
RIDADR	UN 3077 9 / PGIII

WS 12 price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W0519	WS-12 ≥98% (HPLC), powder	68489-09-8	5mg	$190	2024-03-01	Buy
Tocris	3040	WS12 ≥99%(HPLC)	68489-09-8	50	$590	2021-12-16	Buy
Tocris	3040	WS12 ≥99%(HPLC)	68489-09-8	10	$141	2021-12-16	Buy
TRC	W500040	WS12	68489-09-8	10mg	$105	2021-12-16	Buy
TRC	W500040	WS12	68489-09-8	25mg	$210	2021-12-16	Buy

Product number	Packaging	Price	Buy
W0519	5mg	$190	Buy
3040	50	$590	Buy
3040	10	$141	Buy
W500040	10mg	$105	Buy
W500040	25mg	$210	Buy

WS 12 Chemical Properties,Uses,Production

Description

WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.

Chemical Properties

WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors.

Uses

WS 12 is a potent TRPM8 agonist.

Trade name

Winsense WS-12 (Renessenz)

Biological Activity

Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).

Biochem/physiol Actions

WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.

storage

Store at -20°C

WS 12 Preparation Products And Raw materials

Raw materials

Preparation Products

WS 12 Suppliers

Global( 111)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Duling International Trade Co. LTD	+8617333973358	sales01@hbduling.cn	China	15664	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	2603	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	+8615373025980	clara@hbshengyang.com	China	783	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8348	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58

Supplier	Advantage
Hebei Duling International Trade Co. LTD	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	58
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from WS 12 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-27	WS-12 68489-09-8	US $20.00-10.00 / kg	1kg	99%	5000 tons	Hebei Duling International Trade Co. LTD
2024-05-10	Cooling agent WS-12 68489-09-8	US $18.00-18.00 / kg	1kg	99.9	5000	Hebei Shengyang Water Conservancy Engineering Co., Ltd.
2024-04-25	Cooling agent WS-12 68489-09-8	US $25.00 / kg	1kg	99%	5000kg/week	Hebei Zhuanglai Chemical Trading Co.,Ltd

WS-12
68489-09-8
US $20.00-10.00 / kg
99%
Hebei Duling International Trade Co. LTD

Cooling agent WS-12
68489-09-8
US $18.00-18.00 / kg
99.9
Hebei Shengyang Water Conservancy Engineering Co., Ltd.

Cooling agent WS-12
68489-09-8
US $25.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

WS 12 Spectrum

WS 12(68489-09-8)¹HNMR

68489-09-8(WS 12)Related Search:

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WS3 WS-383 Menthoxypropanediol Cooler 5(WS-5) 2-Isopropyl-N,2,3-trimethylbutyramide

WS 12

1of3

WS 12 (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide CyclohexanecarboxaMide, N-(4-Methoxyphenyl)-5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)- (2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE Cooling agent WS12 (1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)- N- (4- methoxy phenyl) - menthol -3- carboxylase N-(4-Methoxyphenyl)-p-menthane-3-carboxamide N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12) Cooler than menthol AR-15512 Cooler-12 HEK293T,AVX 012,chronic neuropathic pain,TRP Channel,AR 15512,inhibit,AVX012,WS 12,WS12,WS-12,AR15512,AVX-012,Inhibitor,AR-15512,Transient receptor potential channels,analgesic effect,cultured mouse DRG neurons 68489-09-8