ChemicalBook >> CAS DataBase List >>N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
- CAS No.
- 314054-00-7
- Chemical Name:
- N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
- Synonyms
- C-176;STING inhibitor 1;C-176 STING inhibitor;N-(4-iodophenyl)-5-nitro-2-furamide;N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
- CBNumber:
- CB04522191
- Molecular Formula:
- C11H7IN2O4
- Molecular Weight:
- 358.09
- MDL Number:
- MFCD00784208
- MOL File:
- 314054-00-7.mol
Last updated:2023-06-30 15:45:59
| Boiling point | 361.2±37.0 °C(Predicted) |
|---|---|
| Density | 1.935±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in DMSO (up to 25 mg/ml) |
| pka | 11.14±0.70(Predicted) |
| form | solid |
| color | Brown or yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2559 | C-176 ≥98% (HPLC) | 314054-00-7 | 10mg | $97.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2559 | C-176 ≥98% (HPLC) | 314054-00-7 | 50mg | $237 | 2024-03-01 | Buy |
| Cayman Chemical | 25859 | C-176 | 314054-00-7 | 10mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 25859 | C-176 | 314054-00-7 | 50mg | $170 | 2024-03-01 | Buy |
| Cayman Chemical | 25859 | C-176 | 314054-00-7 | 25mg | $90 | 2024-03-01 | Buy |
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Chemical Properties,Uses,Production
Description
C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation?via?blockade of palmitoylation at Cys91. Treatment of Trex-/-?mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.
storage
Store at -20°C
References
1)Haag?et al.?(2018),?Targeting STING with covalent small-molecule inhibitors; Nature?559?269
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 64)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9756 | 58 |
| Alinda Chemical Ltd. | +7 (495) 672-17-08 | sale@alinda.ru | Russia | 68136 | 55 |
314054-00-7(N-(4-iodophenyl)-5-nitrofuran-2-carboxamide)Related Search:
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
C-176
C-176 STING inhibitor
STING inhibitor 1
2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-
N-(4-iodophenyl)-5-nitro-2-furamide
STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
314054-00-7