Lapatinib Ditosylate
- CAS No.
- 388082-77-7
- Chemical Name:
- Lapatinib Ditosylate
- Synonyms
- GW-572016F;Tykerb Ditosylat;apatinib DitosyL;Tykerb Ditosylate;Tykerb(lapatinib);Lapatinib Tosylate;Lapatinib ditosylate;GW-572016 ditosylate;GW 572016 ditosylate;Lapatinib ditasylate
- CBNumber:
- CB11176387
- Molecular Formula:
- C36H34ClFN4O7S2
- Molecular Weight:
- 753.26
- MDL Number:
- MFCD09264195
- MOL File:
- 388082-77-7.mol
- MSDS File:
- SDS
Melting point | 240-2420C |
---|---|
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | ≥24.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
form | solid |
Water Solubility | Water: Insoluble |
CAS DataBase Reference | 388082-77-7 |
FDA UNII | 4WK72K94MC |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS02 |
---|---|
Signal word | Danger |
Hazard statements | H315-H319-H225 |
Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235 |
Safety Statements | 24/25 |
HS Code | 29420000 |
Lapatinib Ditosylate price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | L175800 | LapatinibDitosylate | 388082-77-7 | 25mg | $65 | 2021-12-16 | Buy |
TRC | L175800 | LapatinibDitosylate | 388082-77-7 | 100mg | $120 | 2021-12-16 | Buy |
TRC | L175800 | LapatinibDitosylate | 388082-77-7 | 1g | $495 | 2021-12-16 | Buy |
ChemScene | CS-0831 | Lapatinibditosylate 99.95% | 388082-77-7 | 5g | $540 | 2021-12-16 | Buy |
ChemScene | CS-0831 | Lapatinibditosylate 99.95% | 388082-77-7 | 50mg | $60 | 2021-12-16 | Buy |
Lapatinib Ditosylate Chemical Properties,Uses,Production
Description
Lapatinib, an ErB-1 and ErB-2 dual kinase inhibitor, was launched for the treatment of advanced or metastatic HER2 (ErbB2) positive breast cancer in women who have received prior therapy. The drug was discovered and developed by GlaxoSmithKline and is also currently being evaluated for several additional cancer indications.
Chemical Properties
Yellow Solid
Uses
Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
Uses
Lapatinib Ditosylate is a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.
Synthesis
The synthesis started with Williamson ether synthesis between 2-chloro-4-nitrophenol (58) and 3-fluorobenzyl bromide to give ether 59 in the following scheme; however, no specific yields were provided. Reduction of the nitro group of compound 59 by catalytic hydrogenation over Pt/C and subsequent condensation of the resulting aniline with 4-chloro-6-iodoquinazoline (61) in refluxing i-PrOH afforded compound 62. 4-Chloro-6-iodoquinazoline (61) was prepared by reacting 6-iodoquinazolin- 4(3H)-one (60) with POCl3 in the presence of triethylamine. Compound 62 was subjected to Stille coupling with 5- dioxolanyl-2-(tributylstannyl)furan (63) in the presence of PdCl2(PPh3)2 to give 64. Acidic hydrolysis of acetal 64 using HCl in THF/H2O provided the corresponding aldehyde which was further subjected to reductive amination with 2-(methan-esulfonyl)ethylamine in the presence of sodium triacetoxyborohydride to yield lapatinib. Lapatinib was treated with ptoluenesulfonic acid solution to give lapatinib ditosylate (IX).
Lapatinib Ditosylate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 | info@pharmachemm.com | China | 225 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12468 | 58 |
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. | +86-0531-69954981 +8615666777973 | dwyane.wang@boyuanpharm.com | China | 211 | 58 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8829 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from Lapatinib Ditosylate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-09-07 | Lapatinib ditosylate
388082-77-7
|
US $0.00-0.00 / kg | 1kg | 99.9% HPLC | 10000 | SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. | ||
2023-06-20 | Lapatinib Ditosylate
388082-77-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2021-07-10 | Lapatinib Ditosylate
388082-77-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Lapatinib ditosylate
388082-77-7
- US $0.00-0.00 / kg
- 99.9% HPLC
- SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
- Lapatinib Ditosylate
388082-77-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- Lapatinib Ditosylate
388082-77-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd