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Gefitinib-d6

Gefitinib-d6 Structure
Gefitinib-d6 structure
CAS No.
1228664-49-0
Chemical Name:
Gefitinib-d6
Synonyms
Gefitinib-d6;[2H6]-Gefitinib;Hexadeuterated gefitinib;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
CBNumber:
CB12674404
Molecular Formula:
C22H24ClFN4O3
Molecular Weight:
446.91
MDL Number:
MFCD21363632
MOL File:
1228664-49-0.mol
Last updated:2023-06-08 09:03:09
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Gefitinib-d6 Properties

storage temp. Store at -20°C
solubility DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
form A solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501
NFPA 704
0
3 0

Gefitinib-d6 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22364 Gefitinib-d6 ≥99% deuterated forms (d1-d6) 1228664-49-0 500μg $130 2024-03-01 Buy
Cayman Chemical 22364 Gefitinib-d6 ≥99% deuterated forms (d1-d6) 1228664-49-0 1mg $243 2024-03-01 Buy
TRC G304008 Gefitinib-d6 1228664-49-0 10mg $1540 2021-12-16 Buy
TRC G304008 Gefitinib-d6 1228664-49-0 25mg $3520 2021-12-16 Buy
AK Scientific 3663DG Gefitinib-d6 1228664-49-0 1mg $370 2021-12-16 Buy
Product number Packaging Price Buy
22364 500μg $130 Buy
22364 1mg $243 Buy
G304008 10mg $1540 Buy
G304008 25mg $3520 Buy
3663DG 1mg $370 Buy

Gefitinib-d6 Chemical Properties,Uses,Production

Description

Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).

Uses

Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.

Gefitinib-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

Gefitinib-d6 Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 4991 50
Nanjing XiZe Biotechnology CO., Ltd. 025-58362220 15250997978 1511893459@qq.com China 7727 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55954 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Cato Research Chemicals Inc. 020-81215950 4000-868-328 customer@uwalab.com United States 10413 58
Taizhou Nanfeng Pharmaceutical Research Institute 3821987872 nanfengdrug@163.com China 15323 58
Shanghai YuZn Pharm. Technology Co.,Ltd. 15921286451; 15921286451 2010681527@qq.com China 5066 58
Shanghai isotope chemical co.,ltd 021-021-51600108 13062666369 sales@chinaisotope.com China 4272 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5141 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
Nanjing XiZe Biotechnology CO., Ltd. 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Cato Research Chemicals Inc. 58
Taizhou Nanfeng Pharmaceutical Research Institute 58
Shanghai YuZn Pharm. Technology Co.,Ltd. 58
Shanghai isotope chemical co.,ltd 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

1228664-49-0(Gefitinib-d6)Related Search:

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Gefitinib-d6 Hexadeuterated gefitinib [2H6]-Gefitinib N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine 1228664-49-0