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Remdesivir N-2

Remdesivir N-2 structure

CAS No.: 1191237-80-5

Chemical Name:: Remdesivir N-2

Synonyms: GS-5;Remdesivir-015;remdesivir N-2;NSJ-Remdesivir-RS009;Remdesivir Impurity 7;Remdesivir Intermediate 4;Remdesivir Intermediate 2;Remdesivir Related Compound 7;Remdesivir No. 5 Intermediate;Remdesivir O-desphosphate acetonide

CBNumber:: CB15493006

Molecular Formula:: C15H17N5O4

Molecular Weight:: 331.33

MDL Number:: MFCD32693253

MOL File:: 1191237-80-5.mol

Last updated:2023-09-11 16:43:46

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Remdesivir N-2 Properties

Density	1.66±0.1 g/cm3(Predicted)
solubility	DMSO:55.5(Max Conc. mg/mL);167.51(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);15.09(Max Conc. mM) PBS (pH 7.2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM) DMF:12.0(Max Conc. mg/mL);36.22(Max Conc. mM)
form	A solid
pka	14.14±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

NFPA 704

	0
2		0

Remdesivir N-2 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0131976	RemdesivirO-desphosphateacetonideimpurity 99.88%	1191237-80-5	1mg	$230	2021-12-16	Buy
Ambeed	A1220957	(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile 97%	1191237-80-5	1g	$285	2021-12-16	Buy
Ambeed	A1220957	(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile 97%	1191237-80-5	5g	$1048	2021-12-16	Buy
Ambeed	A1220957	(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile 97%	1191237-80-5	100mg	$80	2021-12-16	Buy
Ambeed	A1220957	(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile 97%	1191237-80-5	250mg	$115	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0131976	1mg	$230	Buy
A1220957	1g	$285	Buy
A1220957	5g	$1048	Buy
A1220957	100mg	$80	Buy
A1220957	250mg	$115	Buy

Remdesivir N-2 Chemical Properties,Uses,Production

Uses

Remdesivir N-2 can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in the research and development and chemical production of Remdesivir.

Synthesis

Synthesis_1191237-80-5
5.62g of compound GS-441524 was dissolved in 30mL of acetone, 11.50mL of 2,2-dimethoxypropane and 1.34mL of sulfuric acid were added, stirred at 45??C for half an hour, cooled to 25??C, and the organic solvent was removed by rotary evaporation. It was extracted with 100 mL of ethyl acetate and 100 mL of saturated sodium bicarbonate aqueous solution, and the extraction was repeated three times. The ethyl acetate layers were combined, dried by adding anhydrous sodium sulfate, and filtered to remove sodium sulfate. The organic solvent was removed by rotary evaporation, and column chromatography was performed (eluent: petroleum ether/ethyl acetate (V/V)=1/2) to obtain 6.20 g of compound 5 (white solid, 97% yield).

Remdesivir N-2 synthesis

Synthesis of Remdesivir N-2 from GS-441524 and 2,2-Dimethoxypropane

Remdesivir N-2 Preparation Products And Raw materials

Raw materials

GS-441524 D-Ribofuranose, 1-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,3,5-tris-O-(phenylmethyl)- (3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile Remdesivir impurity2 2,3,5-TRI-O-BENZYL-L-ARABINOFURANOSE

7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE 2,2-Dimethoxypropane

1of2

Preparation Products

Remdesivir

Remdesivir N-2 Suppliers

Global( 108)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Chengdu Feibo Pharm Technology Co., Ltd	15982321820	abby@arkpharm.com	CHINA	3279	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81148696 +8615536356810	1047@dideu.com	China	2033	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8348	58
Nantong Haigine Pharma Technology Co., Ltd	0086-513-86266699		CHINA	156	58
Echemi Group	86-18905328650 18905328650	pharma@echemi.com	CHINA	215	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	431	58

Supplier	Advantage
Anhui Ruihan Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Accela ChemBio Inc.	58
Chengdu Feibo Pharm Technology Co., Ltd	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Nantong Haigine Pharma Technology Co., Ltd	58
Echemi Group	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	58

View Lastest Price from Remdesivir N-2 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-09-11	Remdesivir N-2 1191237-80-5	US $80.00 / kg	1kg	99%	10000tons	Anhui Ruihan Technology Co., Ltd
2022-09-12	Remdesivir N-2 1191237-80-5	US $180.00-162.00 / KG	1KG	99%	9000kg/per week	Hebei Lingding Biotechnology Co., Ltd.
2022-02-25	Remdesivir O-desphosphate acetonide impurity 1191237-80-5	US $5.80 / KG	1KG	98%	100KG	Hong Kong Tiansheng New Material Trading Co., Ltd

Remdesivir N-2
1191237-80-5
US $80.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

Remdesivir N-2
1191237-80-5
US $180.00-162.00 / KG
99%
Hebei Lingding Biotechnology Co., Ltd.

Remdesivir O-desphosphate acetonide impurity
1191237-80-5
US $5.80 / KG
98%
Hong Kong Tiansheng New Material Trading Co., Ltd

1191237-80-5(Remdesivir N-2)Related Search:

2-ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate Remdesivir Remdesivir impurity2 N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester Remdesivir-003-S

(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile Remdesivir Intermediate 4 Remdesivir Related Compound 7 Remdesivir-015 Remdesivir O-desphosphate acetonide impurity (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile (3Ar,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-4-carbonitrile Remdesivir No. 5 Intermediate (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydr NSJ-Remdesivir-RS009 (3ar, 4R, 6R, 6aR) - 4 - (4-aminopyrrole [1,2-f] [1,2,4] triazine-7-yl) - 6 - (hydroxymethyl) - 2,2-dimethyl-tetrahydrofuran [3,4-d] [1,3] dioxazole-4-nitrile 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE-D-ALTRONONITRILE 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-D-Altrononitrile D-ALTRONONITRILE, 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE (3aR,4R,6R,6aR)-4-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile (4R)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile Remdesivir Impurity 7 remdesivir N-2 GS-5 D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- D-Altrononitrile,2-C-(4-aminopyrrolo[2,1-f][1,2,4Chemicalbook]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- Remdesivir Intermediate 2 Remdesivir Acetonide Nitrile Impurity Remdesivir Impurity 7 (Remdesivir Acetonide Nitrile Impurity) Remdesivir O-desphosphate acetonide 1191237-80-5 PEG