PF 750
- CAS No.
- 959151-50-9
- Chemical Name:
- PF 750
- Synonyms
- PF 750;N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide;N-Phenyl-4-(quinolin-3-ylMethyl)piperidine-1-carboxaMide;1-PiperidinecarboxaMide, N-phenyl-4-(3-quinolinylMethyl)-
- CBNumber:
- CB22511241
- Molecular Formula:
- C22H23N3O
- Molecular Weight:
- 345.44
- MDL Number:
- MFCD10567109
- MOL File:
- 959151-50-9.mol
- MSDS File:
- SDS
| Boiling point | 582.7±32.0 °C(Predicted) |
|---|---|
| Density | 1.226 |
| storage temp. | Store at RT |
| solubility | DMSO: >10mg/mL |
| pka | 14.15±0.70(Predicted) |
| form | A crystalline solid |
| color | white to off-white |
| FDA UNII | 7756CPP14K |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
PF 750 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10010908 | PF-750 >98% | 959151-50-9 | 1mg | $18 | 2024-03-01 | Buy |
| Cayman Chemical | 10010908 | PF-750 >98% | 959151-50-9 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 10010908 | PF-750 >98% | 959151-50-9 | 10mg | $129 | 2024-03-01 | Buy |
| Cayman Chemical | 10010908 | PF-750 >98% | 959151-50-9 | 50mg | $553 | 2024-03-01 | Buy |
| Tocris | 3307 | PF750 ≥98%(HPLC) | 959151-50-9 | 50 | $702 | 2021-12-16 | Buy |
PF 750 Chemical Properties,Uses,Production
Description
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-
Uses
Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system
Definition
ChEBI: N-phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide is a member of quinolines.
Biochem/physiol Actions
PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM. PF-750 shows 10-fold better potency than URB597 (Sigma# U4133) after 30 min preincubation. PF-750 is highly selective on FAAH. Even at as high as 500 μM, it had no interactions with many tested enzymes, but URB597 and other known FAAH inhibitors did not perform well at low concentraction (100 μM).
PF 750 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |