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D-(-)-Salicin

CAS No.
138-52-3
Chemical Name:
D-(-)-Salicin
Synonyms
SALICIN;D-SALICIN;SALICOSIDE;WHITE WILLOW;Salicine;Salicylin;Salicin-RM;SALICIN(RG);SALICIN(SH);Salicin >
CBNumber:
CB2349192
Molecular Formula:
C13H18O7
Molecular Weight:
286.28
MDL Number:
MFCD00006590
MOL File:
138-52-3.mol
MSDS File:
SDS
Last updated:2024-10-31 15:41:55

D-(-)-Salicin Properties

Melting point 196-202 °C
Boiling point 388.65°C (rough estimate)
alpha -61.5 º (c=5, water)
Density 1.4340
refractive index -62 ° (C=3, H2O)
storage temp. 2-8°C
solubility 36g/l
form Fine Crystalline Powder
pka 12.80±0.70(Predicted)
color White
Water Solubility 36 g/L (15 ºC), 250 g/L (60 ºC)
Merck 14,8324
BRN 89593
Stability Stable, but light sensitive. Incompatible with strong oxidizing agents.
InChIKey NGFMICBWJRZIBI-MICYEWLZSA-N
LogP -1.232 (est)
CAS DataBase Reference 138-52-3(CAS DataBase Reference)
FDA UNII 4649620TBZ
NIST Chemistry Reference Salicin(138-52-3)
EPA Substance Registry System .beta.-D-Glucopyranoside, 2-(hydroxymethyl)phenyl (138-52-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P280-P302+P352
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37-37-24/25-36
WGK Germany  3
RTECS  LZ5901700
3-10
TSCA  Yes
HS Code  29389090
NFPA 704
1
2 0

D-(-)-Salicin price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S0625 D-(?)-Salicin ≥99% (GC) 138-52-3 5g $57.1 2024-03-01 Buy
Sigma-Aldrich 79588 D-(?)-Salicin analytical standard 138-52-3 100mg $230 2024-03-01 Buy
TCI Chemical S0003 Salicin >98.0%(HPLC) 138-52-3 5g $34 2024-03-01 Buy
TCI Chemical S0003 Salicin >98.0%(HPLC) 138-52-3 25g $98 2024-03-01 Buy
Alfa Aesar A16524 D-(-)-Salicin, 99% 138-52-3 5g $40.2 2024-03-01 Buy
Product number Packaging Price Buy
S0625 5g $57.1 Buy
79588 100mg $230 Buy
S0003 5g $34 Buy
S0003 25g $98 Buy
A16524 5g $40.2 Buy

D-(-)-Salicin Chemical Properties,Uses,Production

Description

D(-)-Salicin is a traditional medicine which has been known to exhibit anti-inflammation and other therapeutic activities, it can inhibit the LPS-induced inflammation in RAW264.7 cells and mouse models.

Chemical Properties

white crystals or powder

Uses

D-(-)-Salicin has been used:

  • to study its in vitro anticoagulant and antiplatelet activities
  • as a standard in high performance liquid chromatography method (HPLC) for quantitation of salicin from willow plant
  • as a tastant in taste threshold assay
  • as a constituent of nutrient agar-salicin medium for selective isolation of Lactobacillus paracasei

Uses

Standard substrate in evaluating enzyme Preparations contg b-glucosidase: Weidenhagen, Z. Ver. Zucker-Ind. 79, 591 (1929).

Uses

analgesic, antipyretic

Uses

H1 antihistamine (nonsedating)

Definition

ChEBI: An aryl beta-D-glucoside that is the beta-D-glucoside of the phenolic hydroxy group of salicyl alcohol.

General Description

Salicin is a non-phenolic glucosidic compound extracted from meadowsweet (Filipendula ulmaria L). It is majorly used as a substitute for quinine. Salicin can be used as a therapeutic for patients suffering from rheumatic fever. Salicin acts a metabolic precursor for salicylic acid. It is a novel phytochemical that exhibits immunological cross functions in plants and humans. Salicin facilitates growth and reproduction in plants. In addition, It also protects plants against biotic and abiotic stress.

Biochem/physiol Actions

D-(?)-Salicin exerts anti-rheumatism and anti-inflammatory activities. It inhibits lipopolysaccharide (LPS) induced inflammation in in vitro and in vivo studies. It regulates different signaling pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK). It also regulates cytokines concentration such as tumor necrosis factor-alpha(TNF-α), interleukin-1β, interleukin-6, and interleukin-10.

Purification Methods

Crystallise D(-)-salicin from EtOAc, EtOH or water and sublime it at 190-195o/12mm. [Armour et al. J Chem Soc 412 1961, IR: Pearl & Darling J Org Chem 24 731 1959, Beilstein 17 III/IV 2986, 17/7 V 113.]

16643-37-1
138-52-3
Synthesis of D-(-)-Salicin from 2-[(Acetyloxy)methyl]phenyl β-D-glucopyranoside 2,3,4,6-tetraacetate

D-(-)-Salicin Preparation Products And Raw materials

Global( 547)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953 sales@pioneerbiotech.com China 3000 58
Changsha Staherb Natural Ingredients Co., Ltd.
+86-0731-84213302 +86-18374838656 info@staherb.cn China 1025 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12829 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850 info@fortunachem.com China 5986 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126 info@binbobiological.com China 346 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 18648 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21639 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9220 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32820 60

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View Lastest Price from D-(-)-Salicin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Salicin pictures 2024-10-31 Salicin
138-52-3
US $29.00 / mL 99.93% 10g TargetMol Chemicals Inc.
Salicin pictures 2024-10-31 Salicin
138-52-3
US $29.00 / mL 99.93% 10g TargetMol Chemicals Inc.
D-(-)-Salicin pictures 2024-10-31 D-(-)-Salicin
138-52-3
US $0.00-0.00 / KG 1KG 98%min 10tons/month WUHAN FORTUNA CHEMICAL CO., LTD
  • Salicin pictures
  • Salicin
    138-52-3
  • US $29.00 / mL
  • 99.93%
  • TargetMol Chemicals Inc.
  • Salicin pictures
  • Salicin
    138-52-3
  • US $29.00 / mL
  • 99.93%
  • TargetMol Chemicals Inc.
  • D-(-)-Salicin pictures
  • D-(-)-Salicin
    138-52-3
  • US $0.00-0.00 / KG
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
D-(-)-SALICIN 2-(HYDROXYMETHYL)PHENYL-BETA-D-GLUCOPYRANOSIDE 2-(HYDROXYMETHYL)PHENYL-BETA-D-GLUCOPYYRANOSIDE 2-(HYDROXYMETHYL)PHENYL-BETA-D-GLUCOSIDE 2-(Hydroxymethyl)phenyl hexopyranoside SALICYLALDEHYDE-B-D-GLUCOSIDE SALICYLALCOHOL BETA-D-GLUCOSIDE SALICYL ALCOHOL GLUCOSIDE SALIGENIN-B-D-GLUCOSIDE SALIGENIN-B-D-GLYCOPYRANOSIDE alpha-hydroxy-o-tolyl beta-D-glucopyranoside White willow bark P.E Salicin 15% 25% 30% HPLC SALICIN, 98+% HPLC D-SALICIN, FOR BIOCHEMISTRY SalicinForMicrobiology 2-(hydroxymethyl)phenyl-beta-d-glucopyranosid Benzyl alcohol, o-hydroxy-, O-glucoside beta-D-Glucopyranoside, 2-(hydroxymethyl)phenyl beta-d-glucopyranoside,2-(hydroxymethyl)phenyl o-(Hydroxymethyl)phenyl beta-D-glucopyranoside Salicine Saligenin-beta-D-glucopyranoside saligeninbeta-d-glucopyranoside β-D-Glucopyranoside, 2-(hydroxymethyl)phenyl (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[2-(hydroxymethyl)phenoxy]oxane-3,4,5-triol SALICIN(AHP) SALICIN(RG) Saligenin-β-D-glucopyranoside D(-)-Salicin, 99+% White Willow Bark P.E or Salicin D-Salicin, natural (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(2-(hydroxymethyl)-phenoxy)tetrahydro-2H-pyran-3,4,5-trio Salicin from Plant Extract≥ 98% (HPLC) Salicin/Salix alba extract SALICIN(SH) saligenin-β-glucopyranoside saligenin glucoside SALICIN ((2-HYDROXYMETHYL-PHENYL)-SS-D-GLUCOPYRANOSIDE) D-(-)-SALICIN WITH HPLC D-(-)-SALICIN hplc Salix alba L. 2-(Hydroxymethyl)phenyl-β-D-glucopyranoside, D(-)-Salicin 1-b-D-Glucosyloxy-2-hydroxymethylbenzene o-(Hydroxymethyl)phenyl b-D-glucopyranoside D-()-Salicin ,98% 2-(Hydroxymethyl)phe D(-)-Salicin, 99+% 25GR (2R,3S,4S,5R,6S)-2-(HydroxyMethyl)-6-(2-(hydroxyMethyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol Salicin (Salicoside, Salicine) Salicoside, Salicine D-()-Salicin 138-52-3 White Willow Extract (Standard) Salicin > Salicin CRS Brazilian Acai    hot selling salicin D-(-)-Salicin USP/EP/BP Willow Sterm Bark