Davercin
- CAS No.
- 55224-05-0
- Chemical Name:
- Davercin
- Synonyms
- erythromycin A cyclic 11,12-carbonate;CWE;DAVERCIN;Dravercin;Davercin USP/EP/BP;Erythromycin cycloester;Eritromicina A carbonato;Erythromycin Impurity 10;Erythromycin Impurity 50;Erythromycin Cyclocarbonate
- CBNumber:
- CB2966540
- Molecular Formula:
- C38H65NO14
- Molecular Weight:
- 759.93
- MDL Number:
- MFCD28348360
- MOL File:
- 55224-05-0.mol
- MSDS File:
- SDS
| Melting point | >135°C (dec.) |
|---|---|
| Boiling point | 859.8±65.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| pka | 13.49±0.70(Predicted) |
| form | Solid |
| color | White |
| FDA UNII | 4H3125L82R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Toxicity | LD50 oral in rat: 5800mg/kg |
Davercin price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21348 | Davercin ≥98% | 55224-05-0 | 1mg | $67 | 2024-03-01 | Buy |
| Cayman Chemical | 21348 | Davercin ≥98% | 55224-05-0 | 5mg | $199 | 2024-03-01 | Buy |
| Cayman Chemical | 21348 | Davercin ≥98% | 55224-05-0 | 10mg | $332 | 2024-03-01 | Buy |
| Cayman Chemical | 21348 | Davercin ≥98% | 55224-05-0 | 25mg | $746 | 2024-03-01 | Buy |
| TRC | E650045 | ErythromycinCyclocarbonate | 55224-05-0 | 2.5mg | $110 | 2021-12-16 | Buy |
Davercin Chemical Properties,Uses,Production
Description
Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 μg/ml). Davercin is non-toxic to mice and rats (LD50s = 4.05 and 5.9 g/kg, respectively). Formulations containing davercin have been used to treat a variety of urogenital bacterial infections.
Uses
Erythromycin Cyclocarbonate is a derivative of Erythromycin (E649950), an antibcterial agent working on the 50S ribosomal subunit.
Uses
Davercin (erythromycin A cyclic 11,12-carbonate) is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.
Definition
ChEBI: Davercin is an aminoglycoside.
Davercin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3082 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
