curvularin
- CAS No.
- 10140-70-2
- Chemical Name:
- curvularin
- Synonyms
- curvularin;(S)-Curvularin;S-Curvularin, NSC 166071;2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-
- CBNumber:
- CB31341734
- Molecular Formula:
- C16H20O5
- Molecular Weight:
- 292.33
- MDL Number:
- MFCD09752718
- MOL File:
- 10140-70-2.mol
| Melting point | 206-206.5° |
|---|---|
| alpha | D18 -36.3° (c = 3.8 in ethanol) |
| Boiling point | 557.0±29.0 °C(Predicted) |
| Density | 1.200±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble1mg/mL |
| pka | 7.58±0.40(Predicted) |
| form | powder |
| color | Off-white |
| FDA UNII | WT39K5T3BX |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29419000 | |||||||||
| NFPA 704 |
|
curvularin price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0772 | Curvularin from | 10140-70-2 | 5mg | $205.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0772 | Curvularin from | 10140-70-2 | 1mg | $109 | 2022-05-15 | Buy |
| Cayman Chemical | 21758 | Curvularin ≥98% | 10140-70-2 | 1mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 21758 | Curvularin ≥98% | 10140-70-2 | 5mg | $270 | 2024-03-01 | Buy |
| TRC | C844503 | Curvularin | 10140-70-2 | 1mg | $50 | 2021-12-16 | Buy |
curvularin Chemical Properties,Uses,Production
Uses
Curvularin is a potent antifungal and mycotoxin that also inhibits NO production.
Uses
Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species, including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.
storage
+4°C
curvularin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 1388 | 58 |