2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- CAS No.
- 32384-65-9
- Chemical Name:
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- Synonyms
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone;D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, δ-lactone;Dagliptin Impurity;oxy)-6-((triMethyL;Cagliflozin Impurity 9;Englitazinintermediate;Dapagliflozin Impurity 12;Canagliflozin Related Impurity 9;(3R,4S,5R,6R)-3,4,5-tris(triMethyL;Canagliflozin Impurity 9(Dagelin impurity 11)
- CBNumber:
- CB32610563
- Molecular Formula:
- C18H42O6Si4
- Molecular Weight:
- 466.87
- MDL Number:
- MFCD22665922
- MOL File:
- 32384-65-9.mol
- MSDS File:
- SDS
Boiling point | 417℃ |
---|---|
Density | 0.97 |
Flash point | 171℃ |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly) |
form | Oil |
color | Colourless to Pale Yellow |
Stability | Moisture Sensitive |
InChI | InChI=1/C18H42O6Si4/c1-25(2,3)20-13-14-15(22-26(4,5)6)16(23-27(7,8)9)17(18(19)21-14)24-28(10,11)12/h14-17H,13H2,1-12H3/t14-,15-,16+,17-/s3 |
InChIKey | VNGTZLYNGGLPIZ-NELUYGJANA-N |
SMILES | O([C@@H]1[C@H](C(=O)O[C@H](CO[Si](C)(C)C)[C@H]1O[Si](C)(C)C)O[Si](C)(C)C)[Si](C)(C)C |&1:1,2,6,13,r| |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P271-P261-P280 |
HS Code | 2931900090 |
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | T279540 | 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone | 32384-65-9 | 5g | $65 | 2021-12-16 | Buy |
TRC | T279540 | 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone | 32384-65-9 | 50g | $185 | 2021-12-16 | Buy |
Biosynth Carbosynth | MT08101 | 2,3,4,6-Tetra-O-trimethylsilyl-D-glucono-1,5-lactone | 32384-65-9 | 10g | $50 | 2021-12-16 | Buy |
Biosynth Carbosynth | MT08101 | 2,3,4,6-Tetra-O-trimethylsilyl-D-glucono-1,5-lactone | 32384-65-9 | 50g | $150 | 2021-12-16 | Buy |
ChemScene | CS-M2269 | (3R,4S,5R,6R)-3,4,5-Tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one >97.0% | 32384-65-9 | 100g | $76 | 2021-12-16 | Buy |
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Chemical Properties,Uses,Production
Description
It is usually used as the intermediate and raw material in the chemistry synthesis and pharmaceutical industry. Especially, this chemical has been widely used in the design and synthesis of sodium-glucose transporter inhibitors.1 For example, this substance can be employed as raw material in the preparation of (1s)-1,5-anhydro-1-c-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol, which is commonly known as Dapagliflozin that act as the sodium dependent glucose transporters for treating type 2 diabetes.2 Moreover, it can also function as the intermediate for synthesizing empagliflozin, which is a novel and selective sodium glucose co-transporter-2 inhibitor.3 In addition, canagliflozin, another sodium glucose co-transporter-2 inhibitor, can be obtained by utilizing this substance as the intermediate.4
Reference
- Guo, C.; Hu, M.; DeOrazio, R. J.; Usyatinsky, A.; Fitzpatrick, K.; Zhang, Z. J.; Maeng, J. H.; Kitchen, D. B.; Tom, S.; Luche, M.; Khmelnitsky, Y.; Mhyre, A. J.; Guzzo, P. R.; Liu, S., The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties. Bioorg. Med. Chem. 2014, 22, 3414-3422.
- S Thirumalai Rajan; Eswaraiah, S., Process for the preparation of (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol and its solvate thereof. US Patent 2015, WO 2015/132803 A2.
- Hrapchak, M.; Latli, B.; Wang, X. J.; Lee, H.; Campbell, S.; Song, J. J.; Senanayake, C. H., Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13. J. Label. Compd. Radiopharm. 2014, 57, 687-694.
- Nomura, S.; Sakamaki, S.; Hongu, M.; Kawanishi, E.; Koga, Y.; Sakamoto, T.; Yamamoto, Y.; Ueta, K.; Kimata, H.; Nakayama, K.; Tsuda-Tsukimoto, M., Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus. J. Med. Chem. 2010, 53, 6355-6360.
Chemical Properties
Pale yellow oil
Uses
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is an antidiabetic agent and an intermediate of Dapagliflozin (D185370). 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone acts as a reagent in the synthesis of trans-cyclohexane-bearing C-glucose as sodium glucose co-transporter 2 inhibitors.
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Suzhou Nordica Biopharma CO.,LTD | +8618136148818 | anna.ran@nordicabio.com | China | 299 | 58 |
Cangzhou Kangrui Pharma Tech Co. Ltd., | +86-18632776803 +86-13833998158 | cangzhoukangrui@126.com | China | 733 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12829 | 58 |
Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | gyd@joiny-pharma.com | China | 254 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 998 | 58 |
Anhui Lianchuang Biological Medicine Co.,Ltd | +8613706129682 | tiffany@langyupharm.com | China | 86 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
View Lastest Price from 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-31 | (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one
32384-65-9
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | ||
2024-10-31 | 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
32384-65-9
|
US $0.00-0.00 / kg | 1kg | 98%min | 1000KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-09-24 | 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
32384-65-9
|
US $0.00 / kg | 1kg | 95% | 500kg | Shanghai Joiny Pharmaceutical Co.,LTD |
- (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one
32384-65-9
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
32384-65-9
- US $0.00-0.00 / kg
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
32384-65-9
- US $0.00 / kg
- 95%
- Shanghai Joiny Pharmaceutical Co.,LTD
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