DIACYLGLYCEROL KINASE INHIBITOR I
- CAS No.
- 93076-89-2
- Chemical Name:
- DIACYLGLYCEROL KINASE INHIBITOR I
- Synonyms
- DKI;DAGK;DGKE;DGKI;DAGK4;DAGK7;DGK-θ;R59022;DKGI-I;DAG KINASE
- CBNumber:
- CB3335279
- Molecular Formula:
- C27H26FN3OS
- Molecular Weight:
- 459.58
- MDL Number:
- MFCD00055114
- MOL File:
- 93076-89-2.mol
- MSDS File:
- SDS
| Boiling point | 619.8±65.0 °C(Predicted) |
|---|---|
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | 0.1 M HCl: slightly soluble |
| form | solid |
| pka | 7.76±0.20(Predicted) |
| color | pale yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | PF550QIT3I |
SAFETY
Risk and Safety Statements
| Safety Statements | 23-24/25 |
|---|---|
| WGK Germany | 3 |
DIACYLGLYCEROL KINASE INHIBITOR I price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D5919 | Diacylglycerol Kinase Inhibitor I solid | 93076-89-2 | 1mg | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | 266785 | Diacylglycerol Kinase Inhibitor I | 93076-89-2 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 16772 | R-59-022 ≥98% | 93076-89-2 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16772 | R-59-022 ≥98% | 93076-89-2 | 5mg | $90 | 2024-03-01 | Buy |
| Sigma-Aldrich | D5919 | Diacylglycerol Kinase Inhibitor I solid | 93076-89-2 | 5mg | $440 | 2024-03-01 | Buy |
DIACYLGLYCEROL KINASE INHIBITOR I Chemical Properties,Uses,Production
Description
R-59022 (93076-89-2) is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 μM in intact platelets).1 Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism.2 Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes.3 Blocks filovirus internalization in host cells.4
Uses
R-59-022 acts as an inducer of apoptosis in glioblastoma cells and avoids apoptosis in non-cancerous cells. This selectivity makes this drug a highly effective anti-cancer agent. Diacylglycerol Kinase inhibitor.
Definition
ChEBI: 6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]-1-piperidinyl]ethyl]-7-methyl-5-thiazolo[3,2-a]pyrimidinone is a diarylmethane.
Biological Activity
Diacylglycerol (DAG) kinase inhibitor (IC 50 = 2.8 μ M); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.
References
de Chaffoy de Courcelles et al. (1985), R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet; J. Biol. Chem., 260 15762 Takita et al. (2011), Diacylglycerol kinase inhibitor R59022-induced autophagy and apoptosis in the neuronal cell line NG108-15; Arch. Biochem. Biophys., 509 197 Martinez et al. (2013), Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes; J. Lipid Res., 54 662 Stewart et al. (2019), A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells; Viruses, 11 206
DIACYLGLYCEROL KINASE INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
DIACYLGLYCEROL KINASE INHIBITOR I Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
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