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4-O-(Carboxymethyl)rifamycin

CAS No.
13929-35-6
Chemical Name:
4-O-(Carboxymethyl)rifamycin
Synonyms
C01848;Nacimycin;Nancimycin;Rifomycin B;NCI-145-604;Rifamycin B CRS;Rifamycin impurity A;Rifaximin EP Impurity B;Rifamycin EP Impurity A;Rifaximin impurity B (EP)
CBNumber:
CB3913884
Molecular Formula:
C39H49NO14
Molecular Weight:
755.8
MDL Number:
MOL File:
13929-35-6.mol
Last updated:2023-05-15 10:43:33

4-O-(Carboxymethyl)rifamycin Properties

Melting point 300° (dec 160-164°)
alpha D20 -11° (methanol)
Boiling point 730.16°C (rough estimate)
Density 1.2421 (rough estimate)
refractive index 1.5350 (estimate)
solubility DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Sonicated)
pka 2.69±0.10(Predicted)
BRN 604953
Stability Unstable in solution
FDA UNII 8DDB535DJI

SAFETY

Risk and Safety Statements

Toxicity LD50 in mice (mg/kg): 2040 i.v., >3000 i.p., s.c., and orally (Sensi, 1964)

4-O-(Carboxymethyl)rifamycin price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R0900000 Rifamycin B European Pharmacopoeia (EP) Reference Standard 13929-35-6 r0900000 $220 2024-03-01 Buy
TRC R508170 Rifamycin B 13929-35-6 50mg $160 2021-12-16 Buy
TRC R508170 Rifamycin B 13929-35-6 500mg $1295 2021-12-16 Buy
American Custom Chemicals Corporation API0009903 RIFAMYCIN B 95.00% 13929-35-6 500MG $1871.1 2021-12-16 Buy
American Custom Chemicals Corporation API0009903 RIFAMYCIN B 95.00% 13929-35-6 50MG $315 2021-12-16 Buy
Product number Packaging Price Buy
R0900000 r0900000 $220 Buy
R508170 50mg $160 Buy
R508170 500mg $1295 Buy
API0009903 500MG $1871.1 Buy
API0009903 50MG $315 Buy

4-O-(Carboxymethyl)rifamycin Chemical Properties,Uses,Production

Uses

Rifamycin B (Rifaximin EP Impurity B) is a Rifamycin (R508200) derivative as antibacterial agent.

Uses

A Rifamycin (R508200) derivative as antibacterial agent.

Definition

ChEBI: Rifamycin B is a carboxylic acid, an acetate ester, an organic heterotetracyclic compound and a member of rifamycins. It is a conjugate acid of a rifamycin B(2-).

Purification Methods

Rifamycin B forms yellow needles from *C6H6. Its solubilities are: H2O (0,027%), MeOH (2.62%) and EtOH (0.44%). It has UV max at 223, 304 and 245nm (A 1cm 555, 275 and 220). [Oppolzer & Prelog Helv Chim Acta 56 2287 1973, Oppolzer et al. Experientia 20 336 1964, X-ray: Brufani et al. Experientia 20 339 1964.]

4-O-(Carboxymethyl)rifamycin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 49)Suppliers
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Henan Tianfu Chemical Co.,Ltd.
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Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
Rifamycin impurity A Rifaximin EP Impurity B Rifamycin, 4-O-(carboxymethyl)- 4-O-(Carboxymethyl)rifamycin Nacimycin Nancimycin NCI-145-604 Rifomycin B C01848 Rifaximin impurity B (EP) Rifaximin Impurity 2 (Rifaximin EP Impurity B) Rifamycin EP Impurity A Rifaximin EP Impurity B (Rifamycin B) Rifamycin B CRS Rifamycin Impurity 1(Rifamycin EP Impurity A)(Rifamycin B) 4-O-(Carboxymethyl)-Rifamycin (Rifaximin Impurity) Rifaximin EP Impurity B(Rifamycin EP Impurity A) 13929-35-6 C39H49NO14 Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals