2-ETHOXY-6,9-DIAMINOACRIDINE
- CAS No.
- 442-16-0
- Chemical Name:
- 2-ETHOXY-6,9-DIAMINOACRIDINE
- Synonyms
- RIVANOL;ACRINOL;Etakridin;Ethacridine;Ethacrindine;2-Ethoxy-6,9-acridinediamine;7-Ethoxy-3,9-acridinediamine;6,9-DIAMINO-2-ETHOXYACRIDINE;2-ETHOXY-6,9-DIAMINOACRIDINE;7-ETHOXY-ACRIDINE-3,9-DIAMINE
- CBNumber:
- CB4116840
- Molecular Formula:
- C15H15N3O
- Molecular Weight:
- 253.3
- MDL Number:
- MFCD00438481
- MOL File:
- 442-16-0.mol
| Melting point | 226° |
|---|---|
| Boiling point | 396.5°C (rough estimate) |
| Density | 1.0966 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | 2-8°C |
| pka | 11.22±0.10(Predicted) |
| FDA UNII | WIX85M1A6R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
2-ETHOXY-6,9-DIAMINOACRIDINE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E676543 | 7-Ethoxyacridine-3,9-diamine | 442-16-0 | 50mg | $250 | 2021-12-16 | Buy |
| AK Scientific | H779 | 7-Ethoxyacridine-3,9-diamine | 442-16-0 | 250mg | $195 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0015644 | ETHACRIDINE 95.00% | 442-16-0 | 250MG | $462 | 2021-12-16 | Buy |
| AK Scientific | H779 | 7-Ethoxyacridine-3,9-diamine | 442-16-0 | 1g | $489 | 2021-12-16 | Buy |
| Alichem | 442160 | 7-Ethoxyacridine-3,9-diamine | 442-16-0 | 5g | $508.8 | 2021-12-16 | Buy |
2-ETHOXY-6,9-DIAMINOACRIDINE Chemical Properties,Uses,Production
Originator
Rivanol,Sopharma
Uses
7-ethoxyacridine-3,9-diamine is used in biological studies for cancer regression by inducing a regeneration-like response by activating expression and/or function of YAP and/or TAZ.
Definition
ChEBI: Ethacridine is a member of acridines.
Manufacturing Process
A mixture of 250 parts by volume of ethylene glycol, 50 parts by weight of 6-
nitro-9-chloro-2-ethoxyacridine (obtained by reaction of 52 parts by weight of
30 nitro-4-ethoxy-diphenylamine-6-carboxylic acid with phosphorous
oxychloride), 10 parts by weight of ammonium chloride, and 11 parts by
weight of urea were heated to 170°C and stirred for 1 hour at 170°-175°C.
Subsequently, the whole was cooled to 100°C, the reaction mixture was
introduced into 1000 parts by volume of water, rendered acidic to Congo
paper by means of hydrochloric acid and the 6-nitro-9-amino-2-ethoxyacridine
precipitated was filtered off. By reduction iron according to Bechamp, 6,9-
diamino-2-ethoxy-acridine hydrochloride was obtained with yield of 83% as
the yellow needles. The base was prepared by adding an equivalent of NaOH.
MP: 124°C.
In practice it is usually used as lactate.
Therapeutic Function
Antiseptic, Antibacterial
Purification Methods
It crystallises from 50% EtOH or EtOH as orange-yellow crystals. It also crystallises as a monohydrate m 116-118o. It has a pK2 0 of 11.04 in 50% aqueous EtOH. The methiodide is soluble in H2O and has m 332-334o (dec) (from aqueous Me2CO). [Albert & Gledhill J Soc Chem Ind 61 159 1942, Foye et al. J Pharm Sci 57 1795 1968, Albert & Goldacre J Chem Soc 708 1946, Beilstein 22 II 458, 22 III/IV 6679, 22/12 V 243.]
2-ETHOXY-6,9-DIAMINOACRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-ETHOXY-6,9-DIAMINOACRIDINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28557 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 19949 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from 2-ETHOXY-6,9-DIAMINOACRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-16 | Ethacridine
442-16-0
|
US $80.00 / KG | 1KG | >99% | 20tons | Weijer International Trade (Hebei) Co., Ltd | |
 |
2021-07-23 | 2-ETHOXY-6,9-DIAMINOACRIDINE USP/EP/BP
442-16-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-04 | Ethacridine Lactate
442-16-0
|
US $0.00-0.00 / KG | 1KG | 99.0% | 600 Tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Ethacridine
442-16-0
- US $80.00 / KG
- >99%
- Weijer International Trade (Hebei) Co., Ltd
-
- 2-ETHOXY-6,9-DIAMINOACRIDINE USP/EP/BP
442-16-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Ethacridine Lactate
442-16-0
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd