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ABC294640

CAS No.
915385-81-8
Chemical Name:
ABC294640
Synonyms
CS-802;ABC294640;ABC294640(Opaganib);Opaganib (ABC294640);3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide;3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide;Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl);3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide;ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE.;ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB
CBNumber:
CB42624930
Molecular Formula:
C23H25ClN2O
Molecular Weight:
380.91
MDL Number:
MFCD22666355
MOL File:
915385-81-8.mol
MSDS File:
SDS
Last updated:2024-10-31 18:15:48

ABC294640 Properties

Boiling point 589.5±50.0 °C(Predicted)
Density 1.273±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility ≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
form solid
pka 14.57±0.40(Predicted)
FDA UNII DRG21OQ517

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
NFPA 704
0
2 0

ABC294640 price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10587 ABC294640 ≥98% 915385-81-8 1mg $44 2024-03-01 Buy
Cayman Chemical 10587 ABC294640 ≥98% 915385-81-8 5mg $140 2024-03-01 Buy
Cayman Chemical 10587 ABC294640 ≥98% 915385-81-8 10mg $235 2024-03-01 Buy
Cayman Chemical 10587 ABC294640 ≥98% 915385-81-8 25mg $479 2024-03-01 Buy
Biosynth Carbosynth BA162479 ABC 294640 915385-81-8 100mg $480 2021-12-16 Buy
Product number Packaging Price Buy
10587 1mg $44 Buy
10587 5mg $140 Buy
10587 10mg $235 Buy
10587 25mg $479 Buy
BA162479 100mg $480 Buy

ABC294640 Chemical Properties,Uses,Production

Description

ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM). It inhibits SPHK2 (IC50 = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when used at concentrations ranging from 5 to 25 μM. ABC294640 is inactive against a panel of 20 lipid-regulated kinases at 50 μM. It decreases sphingosine-1-phosphate (S1P) production in MDA-MB-231 cells in a concentration-dependent manner. ABC294640 inhibits proliferation of a variety of cancer cells, including HepG2 liver, A-498 kidney, PANC-1 pancreas, and HT-29 colon cells (IC50s = 6, 12.2, 32.8, and 48.1 μM, respectively). It reduces actin filament polymerization in, and cell migration of, A-498 cells in a scratch assay. Oral administration of ABC294640 (35 and 100 mg/kg every other day) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma. It also reduces colonic inflammation in mouse and rat models of Crohn’s disease induced by trinitrobenzene sulfonic acid (TNBS).

Uses

Opaganib is used in treating iatrogenic autoimmune colitis.

Definition

ChEBI: 3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)-1-adamantanecarboxamide is an organochlorine compound.

References

[1] french k j, zhuang y, maines l w, et al. pharmacology and antitumor activity of abc294640, a selective inhibitor of sphingosine kinase-2. journal of pharmacology and experimental therapeutics, 2010, 333(1): 129-139.
[2] antoon j w, white m d, meacham w d, et al. antiestrogenic effects of the novel sphingosine kinase-2 inhibitor abc294640. endocrinology, 2010, 151(11): 5124-5135.

3731-53-1
1057292-87-1
915385-81-8
Synthesis of ABC294640 from 4-Pyridinemethaneamine and Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

ABC294640 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 84)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32820 60
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32024 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38463 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139 orders@jknbiochem.com China 5221 58

View Lastest Price from ABC294640 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Opaganib pictures 2024-10-31 Opaganib
915385-81-8
US $34.00-77.00 / mg 99.71% 10g TargetMol Chemicals Inc.
ABC294640 pictures 2020-01-13 ABC294640
915385-81-8
US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co
  • Opaganib pictures
  • Opaganib
    915385-81-8
  • US $34.00-77.00 / mg
  • 99.71%
  • TargetMol Chemicals Inc.
  • ABC294640 pictures
  • ABC294640
    915385-81-8
  • US $9.80 / KG
  • ≥99%
  • Career Henan Chemical Co

ABC294640 Spectrum

915385-81-8(ABC294640)Related Search:

ABC294640 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl) ABC294640(Opaganib) 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB CS-802 ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE. Opaganib (ABC294640) 3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide 915385-81-8