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Epacadostat (INCB024360)

Epacadostat (INCB024360) Structure
Epacadostat (INCB024360) structure
CAS No.
1204669-58-8
Chemical Name:
Epacadostat (INCB024360)
Synonyms
Epacadostat;CS-1617;INCB02436;INCN024360;(1204669-37-3);Epacadostat(INCB024360);INCB-24360(INCB-024360);Epacadostat(INCN024360);IDO inhibitor(INCB024360);INCB 024360 ， Epacadostat
CBNumber:
CB43038482
Molecular Formula:
C11H13BrFN7O4S
Molecular Weight:
438.23
MDL Number:
MFCD29075639
MOL File:
1204669-58-8.mol
Last updated:2023-06-08 09:02:45
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Epacadostat (INCB024360) Properties

Melting point 159 - 161°C
Boiling point 700.9±70.0 °C(Predicted)
Density 2.01±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to at least 25 mg/ml)
form solid
pka 7.65±0.69(Predicted)
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII 71596A9R13
NCI Drug Dictionary epacadostat
ATC code L01XX58

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Danger
Hazard statements  H332-H302-H312
Precautionary statements  P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501
NFPA 704
0
3 0

Epacadostat (INCB024360) price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19875 INCB024360 ≥98% 1204669-58-8 1mg $32 2024-03-01 Buy
Cayman Chemical 19875 INCB024360 ≥98% 1204669-58-8 5mg $139 2024-03-01 Buy
Cayman Chemical 19875 INCB024360 ≥98% 1204669-58-8 10mg $214 2024-03-01 Buy
Cayman Chemical 19875 INCB024360 ≥98% 1204669-58-8 25mg $494 2024-03-01 Buy
Usbiological 474114 Epacadostat 1204669-58-8 10mg $460 2021-12-16 Buy
Product number Packaging Price Buy
19875 1mg $32 Buy
19875 5mg $139 Buy
19875 10mg $214 Buy
19875 25mg $494 Buy
474114 10mg $460 Buy

Epacadostat (INCB024360) Chemical Properties,Uses,Production

Description

Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with an IC50 value of 7.1 nM in HeLa cells that demonstrates little activity against the related enzymes IDO2 or tryptophan 2,3-dioxygenase (TDO). It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells. Epacadostat can also inhibit tumor growth in tumor-bearing mice in a lymphocyte-dependent manner.

Uses

Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).

target

IDO1

References

1) Liu?et al.?(2010),?Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity;?Blood?115?3520 2) Koblish?et al.?(2010),?Hydroxyamidine Inhibitors of Indolamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors;?Mol. Cancer Ther.?9?489 3) Jochems?et al.?(2016),?The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells;?Oncotarget?7?37762 4) Yentz and Smith (2018),?Indoleamine-2,3-dioxygenase Inhibition as a Strategy to Augment Cancer Immunotherapy;?BioDrugs?32?311 5) Zhu??et al.?(2019),?Indoleamine Dioxygenase Inhibitors: Clinical Rationale and Current Development;?Curr. Oncol. Rep.?21?2 6) Mitchell?et al.?(2018),?Epacadostat Plus Pembrolizumab in Patients with Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037);?J. Clin. Oncol.?36?3223

Epacadostat (INCB024360) Preparation Products And Raw materials

Raw materials

Preparation Products

Epacadostat (INCB024360) Suppliers

Global( 163)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2141 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10326 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Biochempartner 		58
Accela ChemBio Inc. 		58
BOC Sciences 		58
career henan chemical co 		58
Hubei Ipure Biology Co., Ltd 		58

View Lastest Price from Epacadostat (INCB024360) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Epacadostat (INCB024360) pictures 2022-02-19 Epacadostat (INCB024360)
1204669-58-8
 US $0.00 / gram 1gram 99% 10kg Zhejiang J&C Biological Technology Co.,Limited
INCB-24360;INCB24360 pictures 2021-07-13 INCB-24360;INCB24360
1204669-58-8
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Epacadostat (INCB024360) pictures 2020-01-09 Epacadostat (INCB024360)
1204669-58-8
 US $6.68 / KG 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co
  • INCB-24360;INCB24360 pictures
  • INCB-24360;INCB24360
    1204669-58-8
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Epacadostat (INCB024360) Spectrum

Epacadostat (INCB024360)(1204669-58-8)1HNMR

1204669-58-8(Epacadostat (INCB024360))Related Search:

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BP-1-102 AZD6738 BLU 9931 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione Enasidenib
RVX-208 Nintedanib Ethanesulfonate Salt 1,2,4-Oxadiazol-5(4H)-one, 4-(3-bromo-4-fluorophenyl)-3-[4-[(2-hydroxyethyl)amino]-1,2,5-oxadiazol-3-yl]-

1of4

(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide Epacadostat (INCB24360, INCB024360) N-(3-Bromo-4-fluoro-phenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine INCN024360 (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine Epacadostat(INCN024360) INCB-24360(INCB-024360) Epacadostat(INCB024360) [C(Z)]-4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide 1,2,5-Oxadiazole-3-carboximidamide, 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-, [C(Z)]- IDO inhibitor(INCB024360) (1204669-37-3) INCB024360;INCB-024360;INCB 024360 CS-1617 INCB 024360 ， Epacadostat INCB02436 Epacadostat IDO inhibitor(INCB024360) Epacadostat (Z)-N-(3-Bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine 1204669-58-8