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ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Structure
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- structure
CAS No.
170858-33-0
Chemical Name:
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
Synonyms
U 101387;PNU 101387;PF-05191680;PNU-101387G;Sonepiprazole;Sonepiprazole hydrate;inhibit,Dopamine Receptor,U-101387G,Sonepiprazole,PNU-101387G,Inhibitor;4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate;(S)-4-[4-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]benzenesulfonaMide;4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]benzenesulfonaMide
CBNumber:
CB51245409
Molecular Formula:
C21H27N3O3S
Molecular Weight:
401.52
MDL Number:
MFCD05662325
MOL File:
170858-33-0.mol
MSDS File:
SDS
Last updated:2023-09-04 15:51:00
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Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Properties

storage temp. room temp
solubility DMSO: >10mg/mL
form powder
color white to off-white
FDA UNII O609V24217

SAFETY

Risk and Safety Statements

WGK Germany  3

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0174 Sonepiprazole hydrate ≥98% (HPLC) 170858-33-0 5mg $117 2024-03-01 Buy
Sigma-Aldrich PZ0174 Sonepiprazole hydrate ≥98% (HPLC) 170858-33-0 25mg $426 2024-03-01 Buy
Cayman Chemical 11983 Sonepiprazole ≥98% 170858-33-0 1mg $44 2024-03-01 Buy
Cayman Chemical 11983 Sonepiprazole ≥98% 170858-33-0 5mg $109 2024-03-01 Buy
Cayman Chemical 11983 Sonepiprazole ≥98% 170858-33-0 10mg $193 2024-03-01 Buy
Product number Packaging Price Buy
PZ0174 5mg $117 Buy
PZ0174 25mg $426 Buy
11983 1mg $44 Buy
11983 5mg $109 Buy
11983 10mg $193 Buy

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Chemical Properties,Uses,Production

Description

Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical antipsychotics but it is not effective for positive or negative symptoms of schizophrenia in patients. In a pharmacological model of stress exposure in rhesus monkeys, sonepiprazole reverses stress-induced cognitive deficits.

Uses

Sonepiprazole is a dopamine D4 antagonist with Ki=10 nM.

storage

Store at +4°C

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Suppliers

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94838 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12338 58
UHN Shanghai Research & Development Co., Ltd. 021-58958002 18930822973 SALES@UHNSHANGHAI.COM China 977 58
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9798 50
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Aladdin Scientific 		58
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
Beijing HuaMeiHuLiBiological Chemical 58
UHN Shanghai Research & Development Co., Ltd. 58
Shanghai HuanChuan Industry Co.,Ltd. 50

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Spectrum

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-(170858-33-0)1HNMR
(S)-4-[4-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]benzenesulfonaMide 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]benzenesulfonaMide PF-05191680 PNU 101387 Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- U 101387 Sonepiprazole 4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate PNU-101387G Sonepiprazole hydrate Benzenesulfonamide, 4-[4-[2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]- inhibit,Dopamine Receptor,U-101387G,Sonepiprazole,PNU-101387G,Inhibitor 170858-33-0 70858-33-0 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals Sulfur & Selenium Compounds