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doxorubicin(6-maleimidocaproyl)hydrazone
- CAS No.
- 151038-96-9
- Chemical Name:
- doxorubicin(6-maleimidocaproyl)hydrazone
- Synonyms
- DOXO-EMCH;INNO-206;MC-DOXHZN;Aldoxorubici;Doxorubicin-EMCH;MC DOXHZN,MCDOXHZN;INNO-206 (Aldoxorubicin);Doxorubicin-hydrazone-caproyl-maleimide;doxorubicin(6-maleimidocaproyl)hydrazone;DOXO-EMCH; DOXORUBICIN-EMCH; INNO206;INNO 206;ALDOXORUBICIN
- CBNumber:
- CB51374839
- Molecular Formula:
- C37H42N4O13
- Molecular Weight:
- 750.74838
- MDL Number:
- MFCD15146982
- MOL File:
- 151038-96-9.mol
- MSDS File:
- SDS
Last updated:2023-05-09 09:30:43
| Density | 1.60 |
|---|---|
| solubility | Soluble in DMSO |
| pka | 7.38±0.60(Predicted) |
| FDA UNII | C28MV4IM0B |
SAFETY
Risk and Safety Statements
| Safety Statements | 23-24/25 |
|---|
doxorubicin(6-maleimidocaproyl)hydrazone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A3372 | DOXO-EMCH | 151038-96-9 | 2mg | $113 | 2021-12-16 | Buy |
| ApexBio Technology | A3372 | DOXO-EMCH | 151038-96-9 | 5mg | $188 | 2021-12-16 | Buy |
| ApexBio Technology | A3372 | DOXO-EMCH | 151038-96-9 | 10mg | $255 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005221 | INNO-206 95.00% | 151038-96-9 | 5MG | $922.3 | 2021-12-16 | Buy |
| ApexBio Technology | A3372 | DOXO-EMCH | 151038-96-9 | 50mg | $960 | 2021-12-16 | Buy |
doxorubicin(6-maleimidocaproyl)hydrazone Chemical Properties,Uses,Production
Uses
Doxorubicin-hydrazone-caproyl-maleimide is an albumin-binding prodrug of doxorubicin and a promising clinical candidate for the treatment of a broad range of solid tumors
Biological Activity
the (6-maleimidocaproyl) hydrazone derivative of doxorubicin (inno-206), formerly known as doxo-emch, is a prodrug of the anticancer agent doxorubicin which selectively binds to the cys34 of circulating albumin and accumulates in solid tumors due to passive targeting[1]. inno-206 shows significantly superior antitumor efficacy over free doxorubicin in a spectrum of preclinical tumor models [2].
in vivo
in a murine renal cell carcinoma model and in breast carcinoma xenograft models, inno-206 has shown superior activity over doxorubicin. inno-206 has shown more potent antitumor efficacy than free doxorubicin in the tumor models and is thus a promising clinical candidate for treating a broad range of solid tumors [2].
References
[1]. kratz f. doxo-emch (inno-206): the first albumin-binding prodrug of doxorubicin to enter
doxorubicin(6-maleimidocaproyl)hydrazone Preparation Products And Raw materials
Raw materials
Preparation Products
doxorubicin(6-maleimidocaproyl)hydrazone Suppliers
Global( 51)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9767 | 58 |
View Lastest Price from doxorubicin(6-maleimidocaproyl)hydrazone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | DOXO-EMCH
151038-96-9
|
US $1.00 / g | 1g | 95-99% | 1ton | Career Henan Chemical Co | |
 |
2020-01-13 | doxorubicin(6-maleimidocaproyl)hydrazone
151038-96-9
|
US $1.00 / g | 1g | 99% | 200kg | Career Henan Chemical Co |
-
- DOXO-EMCH
151038-96-9
- US $1.00 / g
- 95-99%
- Career Henan Chemical Co
-
- doxorubicin(6-maleimidocaproyl)hydrazone
151038-96-9
- US $1.00 / g
- 99%
- Career Henan Chemical Co
doxorubicin(6-maleimidocaproyl)hydrazone
(E)-N'-(1-((2R,4R)-4-((2S,4R,5R,6R)-4-aMino-5-hydroxy-6-Methyltetrahydro-2H-pyran-2-yloxy)-2,5,12-trihydroxy-7-Methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)-2-hydroxyethylidene)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide
INNO-206
INNO-206 (Aldoxorubicin)
Doxorubicin-EMCH
N'-[(1E)-1-{4-[(3-Amino-2,3,6-trideoxyhexopyranosyl)oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl}-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexane hydrazide
Aldoxorubici
1H-Pyrrole-1-hexanoicacid, 2,5-dihydro-2,5-dioxo-, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
Doxorubicin-hydrazone-caproyl-maleimide
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
DOXO-EMCH; DOXORUBICIN-EMCH; INNO206;INNO 206;ALDOXORUBICIN
MC-DOXHZN
DOXO-EMCH
MC DOXHZN,MCDOXHZN
151038-96-9
C37H42N4O13