ChemicalBook >> CAS DataBase List >>Methylprednisolone sodium succinate
Methylprednisolone sodium succinate
- CAS No.
- 2375-03-3
- Chemical Name:
- Methylprednisolone sodium succinate
- Synonyms
- METHYLPREDNISOLONE SODIUM SUCCINATE;6α-methylprednisolone 21-hemisuccinate sodium salt;1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT;6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT;(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt;u9088;Metypred;NSC 48989;succinate);solu-medrol
- CBNumber:
- CB5163715
- Molecular Formula:
- C26H33O8.Na
- Molecular Weight:
- 496.53
- MDL Number:
- MFCD00152612
- MOL File:
- 2375-03-3.mol
- MSDS File:
- SDS
Last updated:2024-05-20 11:22:01
| Melting point | >186°C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | lyophilized powder |
| color | White to Off-White |
| InChIKey | FQISKWAFAHGMGT-JXAFMBTDNA-M |
| SMILES | [C@]12(C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)CCC([O-])=O)O)C)[H].[Na+] |&1:0,2,9,11,13,15,17,20,r| |
| CAS DataBase Reference | 2375-03-3(CAS DataBase Reference) |
| FDA UNII | LEC9GKY20K |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H351-H360 | |||||||||
| Precautionary statements | P201-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 61-40 | |||||||||
| Safety Statements | 53-22-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TU4154060 | |||||||||
| Toxicity | LD50 oral in rat: > 5gm/kg | |||||||||
| NFPA 704 |
|
Methylprednisolone sodium succinate price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M3781 | 6α-Methylprednisolone 21-hemisuccinate sodium salt lyophilized powder | 2375-03-3 | 25MG | $78.7 | 2023-06-20 | Buy |
| Sigma-Aldrich | M3781 | 6α-Methylprednisolone 21-hemisuccinate sodium salt lyophilized powder | 2375-03-3 | 250MG | $411 | 2023-06-20 | Buy |
| Sigma-Aldrich | M3781 | 6α-Methylprednisolone 21-hemisuccinate sodium salt lyophilized powder | 2375-03-3 | 1G | $1300 | 2023-06-20 | Buy |
| Usbiological | 220287 | Succinate | 2375-03-3 | 100Tests | $1048 | 2021-12-16 | Buy |
| TRC | M326725 | 6α-Methylprednisolone21-HemisuccinateSodiumSalt | 2375-03-3 | 100mg | $140 | 2021-12-16 | Buy |
Methylprednisolone sodium succinate Chemical Properties,Uses,Production
Description
Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. It is converted into active prednisolone in the body, which activates glucocorticoid receptor-mediated gene expression. This includes inducing the synthesis of the anti-inflammatory protein IkappaB-alpha and inhibiting the synthesis of nuclear factor kappa B (NF-kappaB). As a result, proinflammatory cytokine production, such as IL-1, IL-2, and IL-6, is down-regulated, and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.
Uses
6α-Methylprednisolone 21-Hemisuccinate is a glucocorticosteroid used in anti-inflammatory medication in the treatment of spinal cord injuries.
Uses
6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.
Definition
ChEBI: Methylprednisolone sodium succinate is a corticosteroid hormone.
brand name
A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).
Biochem/physiol Actions
Glucocorticoid with slightly longer half-life than that of prednisolone.
Methylprednisolone sodium succinate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 140)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4664 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21688 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18444 | 58 |
2375-03-3(Methylprednisolone sodium succinate)Related Search:
1of4
6ALPHA-METHYLPREDNISOLONE 21-HEMISUCCINATE SODIUM SALT
6-ALPHA-METHYLPREDNISOLONE SODIUM SUCCINATE
6α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate
Methylprednisolone sodium succinate (JAN/USP)
6a-Methylprednisolone 21-sodium hemisuccinate
6a-Methylprednisolone 21-sodium succinate
6a-Methylprednisolone sodium hemisuccinate
6a-Methylprednisolone sodium succinate
6a-Methylpregnisolone 21-sodium succinate
6-Methylprednisolone sodium succinate
Metypred
NSC 48989
Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-6a-methyl-, 21-(hydrogen succinate), monosodium salt (8CI)
Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-6a-methyl-, 21-(hydrogen succinate), sodium salt (6CI, 7CI)
METHPREDNISOLONE SODIUM SUCCINATE
solu-medrone
succinate)
u9088
urbasonsolubile
Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6alpha,11beta)-
Methylprodnisolone Sodium Succinate
Methylprednisolone Succinate BP93,USP26
11-beta,17,21-trihydroxy-6-alpha-methyl-1,4-pregnadiene-3,20-dione21-(sodium
4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-(hyd
6a-methylprednisolone21-hemisuccinate*sodium
rogensuccinate),monosodiumsalt
solu-medrol
Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6a,11b)- (9CI)
Sodium methylprednisolone succinate
Succinic acid, 21-monoester with 11b,17,21-trihydroxy-6a-methylpregna-1,4-diene-3,20-dione, monosodium salt (8CI)
21-(3-Sodiooxycarbonyl-1-oxopropoxy)-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione
Sol-Melcort
6alpha-Methylprednis
Methylprednisolone SodiuM Succinate Sterile Buffer
MethylprednisoloneSodiuM-SuccinateforInjection
6a-Methylprednisolone 21-succinate sodium
21-Succinate sodium salt
Pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-Methyl-, MonosodiuM salt, (6a,11b)-
6α-Methylprednisolone 21-hemisuccinate Sodium
(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt
6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT
1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT
6α-methylprednisolone 21-hemisuccinate sodium salt
METHYLPREDNISOLONE SODIUM SUCCINATE
6α-Methylprednisolone 21-hemisuccinate sodium salt
6α-Methylprednisolone21-hemisuccinatesodiumsal
Levocarnitine Impurity 58
1, 4-PREGNADIEN-6α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-SUCCINATE, SODIUM SALT
6 alpha-Methylprednisolone Sodium Hemisuccinate
2375-03-3
2375-3-3
2374-03-3
173553
C26H33NaO8
C26H34O8Na
C26H33O8Na
Hormones
Corticosterone