RSV604
- CAS No.
- 676128-63-5
- Chemical Name:
- RSV604
- Synonyms
- RSV604;CS-2092;RSV604;RSV 604;Urea, N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(2-fluorophenyl)-;(S)-1-(2-fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea;virus,Respiratory syncytial virus,A 60444,respiratory,protein,inhibit,RSV,syncytial,A-60444,Inhibitor,A60444,RSV604,RSV 604,nucleocapsid,RSV-604
- CBNumber:
- CB53041458
- Molecular Formula:
- C22H17FN4O2
- Molecular Weight:
- 388.39
- MDL Number:
- MFCD28963952
- MOL File:
- 676128-63-5.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:20): 0.04 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml |
| form | A solid |
| FDA UNII | 6NF9HI6D98 |
RSV604 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29041 | RSV-604 | 676128-63-5 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 29041 | RSV-604 | 676128-63-5 | 25mg | $381 | 2024-03-01 | Buy |
| Cayman Chemical | 29041 | RSV-604 | 676128-63-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29041 | RSV-604 | 676128-63-5 | 10mg | $184 | 2024-03-01 | Buy |
| AK Scientific | 8549CN | 1-(2-Fluorophenyl)-3-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea | 676128-63-5 | 5mg | $209 | 2021-12-16 | Buy |
RSV604 Chemical Properties,Uses,Production
Biological Activity
RSV604 (A-60444), a novel benzodiazepine, is an inhibitor of respiratory syncytial virus (RSV) with EC50 of 0.86 μM. It has the potential to treat RSV-related diseases. Phase 2.
in vitro
RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC 50 s ranging from 0.5 to 0.9 μM in plaque reduction assay.
It (6 days) inhibits RSV-induced HEp-2 cell death, with an EC 50 of 0.86 μM.
Also RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC 50 of 1.7 μM.
RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency.
target
| Target | Value |
| RSV (Cell-free assay) | 0.86 μM(EC50) |
RSV604 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4664 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |