EPTAPIRONE
- CAS No.
- 179756-58-2
- Chemical Name:
- EPTAPIRONE
- Synonyms
- F 11440;EPTAPIRONE;F-11440;F11440;Eptapirone(F11440);4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione;4-methyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-1,2,4-triazine-3,5(2H,4H)-dione;1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-;Serotonin Receptor,5-HT Receptor,Eptapirone,inhibit,F-11440,5-hydroxytryptamine Receptor,Inhibitor,F11440
- CBNumber:
- CB62448965
- Molecular Formula:
- C16H23N7O2
- Molecular Weight:
- 345.4
- MDL Number:
- MFCD08690608
- MOL File:
- 179756-58-2.mol
| Boiling point | 517.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMF:10.0(Max Conc. mg/mL);28.95(Max Conc. mM) |
| form | A crystalline solid |
| pka | 7.72±0.10(Predicted) |
| FDA UNII | 3M824XRO8N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H226 | |||||||||
| Precautionary statements | P501-P270-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P301+P312+P330-P403+P235 | |||||||||
| NFPA 704 |
|
EPTAPIRONE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23449 | Eptapirone ≥98% | 179756-58-2 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 23449 | Eptapirone ≥98% | 179756-58-2 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 23449 | Eptapirone ≥98% | 179756-58-2 | 10mg | $301 | 2024-03-01 | Buy |
| Cayman Chemical | 23449 | Eptapirone ≥98% | 179756-58-2 | 25mg | $618 | 2024-03-01 | Buy |
| TRC | E591305 | Eptapirone | 179756-58-2 | 10mg | $175 | 2021-12-16 | Buy |
EPTAPIRONE Chemical Properties,Uses,Production
Description
Eptapirone is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 4.8 nM in a radioligand binding assay). It is selective for 5-HT1A over other 5-HT receptor subtypes, dopamine D2 receptors, α1-adrenergic receptors, and histamine H1 receptors (Kis = <10,000, 1,770, 691.8, and <10,000 nM, respectively). Eptapirone inhibits cAMP stimulation induced by forskolin in HA7 cells transfected with human 5-HT1A receptors (EC50 = 158 nM). In vivo, eptapirone increases extracellular 5-HT in the ventral hippocampus of rats (ED50 = 0.049 mg/kg) and serum corticosterone levels when administered p.o. or i.p. (ED50s = 0.16 and 0.057 mg/kg, respectively). It decreases immobility in rats in a forced swim test and increases punished responding in a pigeon conflict procedure, demonstrating antidepressant-like and anxiolytic activity. Eptapirone (2.5 mg/kg, p.o.) also attenuates hypertension and tachycardia induced by sibutramine in rats with no effect on sibutramine-induced hypophagia.
Uses
Eptapirone is 5-HT1A receptor agonist with anxiolytic and antidepressant potential.
Definition
ChEBI: Eptapirone is a N-arylpiperazine.
EPTAPIRONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18219 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
View Lastest Price from EPTAPIRONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | EPTAPIRONE
179756-58-2
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
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- EPTAPIRONE
179756-58-2
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co