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ChemicalBook >> CAS DataBase List >>3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Structure
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one structure
CAS No.
503615-03-0
Chemical Name:
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Synonyms
5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone;TECO-011;Apixaban int3;PR-204 impurity;Apixaban Impurity 19;Apixaban Intermediate3;Apixaban related impurities 1;2-Naphthalenecarboxylicacid,12-amino-,methylester;5-morpholino-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one;Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
CBNumber:
CB62516219
Molecular Formula:
C15H17N3O4
Molecular Weight:
303.31
MDL Number:
MFCD19440872
MOL File:
503615-03-0.mol
MSDS File:
SDS
Last updated:2023-09-06 18:02:29
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3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Properties

Boiling point 506.5±50.0 °C(Predicted)
Density 1.356
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly, Heated)
form Solid
pka 3.11±0.20(Predicted)
color Light Yellow
InChI InChI=1S/C15H17N3O4/c19-15-14(16-8-10-22-11-9-16)2-1-7-17(15)12-3-5-13(6-4-12)18(20)21/h2-6H,1,7-11H2
InChIKey LBFAEOWNWSDWRZ-UHFFFAOYSA-N
SMILES C1(=O)N(C2=CC=C([N+]([O-])=O)C=C2)CCC=C1N1CCOCC1

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M725125 3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one 503615-03-0 5g $745 2021-12-16 Buy
American Custom Chemicals Corporation CHM0389374 3-MORPHOLINO-1-(4-NITROPHENYL)-5,6-DIHYDROPYRIDIN-2(1H)-ONE 95.00% 503615-03-0 5MG $497.13 2021-12-16 Buy
ChemScene CS-M1442 3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 99.68% 503615-03-0 100g $780 2021-12-16 Buy
ChemScene CS-M1442 3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 99.68% 503615-03-0 5g $75 2021-12-16 Buy
ChemScene CS-M1442 3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 99.68% 503615-03-0 10g $125 2021-12-16 Buy
Product number Packaging Price Buy
M725125 5g $745 Buy
CHM0389374 5MG $497.13 Buy
CS-M1442 100g $780 Buy
CS-M1442 5g $75 Buy
CS-M1442 10g $125 Buy

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties,Uses,Production

Description

3-(4-Morpholinyl)-1-(4-nitrophenyl)-5, 6-dihydro-2(1H)-pyridinone is the intermediate for the synthesis of apixaban, which is an anticoagulant for the treatment of venous thromboembolic events. 

References

Chao, H. E., et al. "Synthesis of Apixaban." Chinese Journal of Pharmaceuticals (2014).
https://en.wikipedia.org/wiki/Apixaban

Uses

3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one is a reagent in the synthesis of 4,5-dehydro Apixaban (D229385) an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one synthesis

110-91-8
881386-01-2
503615-03-0
Synthesis of 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one from Morpholine and 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

Apixaban Impurity 17

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Suppliers

Global( 321)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Jianfeng Chemical Co., Ltd
0531-88110457; +8615562555968 info@pharmachemm.com China 223 58
PT CHEM GROUP LIMITED
+86-85511178 +86-85511178 peter68@ptchemgroup.com China 35453 58
Jinan Million Pharmaceutical Co., Ltd
+86-531-68659554 +8613031714605 info@millionpharm.com China 157 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21689 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9341 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Supplier Advantage
Jinan Jianfeng Chemical Co., Ltd
58
PT CHEM GROUP LIMITED
58
Jinan Million Pharmaceutical Co., Ltd
58
Henan Bao Enluo International TradeCo.，LTD 		58
Anhui Ruihan Technology Co., Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58

View Lastest Price from 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone pictures 2024-05-23 3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone
503615-03-0
 US $25.00 / KG 1KG 98% 20 tons Speranza Chemical Co., Ltd.
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one pictures 2024-05-23 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
503615-03-0
 US $2.00 / kg 1kg 99% 1200KG/M Jinan Million Pharmaceutical Co., Ltd
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one pictures 2024-05-22 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
503615-03-0
 US $100.00-60.00 / kg 100kg 99.99% 100Tons Hebei Dangtong Import and export Co LTD

503615-03-0(3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one)Related Search:

ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban IMpurity 6
1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban Impurity 12 Apixaban 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
Apixaban IMpurity 3 Apixaban Impurity 17 Apixaban IMpurity 4 (BMS-728626-01)

1of4

3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone Apixaban Intermediate3 5-morpholin-4-yl-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one 3-(Morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one (Nitro MPDP) 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridi... Apixaban intermediates，5,6-Dihydro-3-(4-morpholinyl)-1-(4- nitrophenyl)-2(1H)-pyridinone 2(1H)-Pyridinone, 5,6-dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)- Apixaban related impurities 1 Apixaban int3 3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one 5,6 - dihydro-3 - (4 - morpholin-yl) -1 - (4 - nitrophenyl) -2 (1H) - pyridone 5-morpholino-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one Apixaban Impurity 19 5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 2-Naphthalenecarboxylicacid,12-amino-,methylester TECO-011 5,6-Dihydro-3-morpholino-1-(4-nitrophenyl) pyridine-2(1H)-one PR-204 impurity 1-(4-Nitrophenyl)- 3-Morpholin- 4-yl-5,6- dihydopyridin- 2(1H)-one 503615-03-0 503615-03-0