C 646
- CAS No.
- 328968-36-1
- Chemical Name:
- C 646
- Synonyms
- 104475;C647;C 646;CS-1006;C274682;C-646;C 646;C 646 USP/EP/BP;C646 C-646 C 646;C646, p300/CBP Inhibitor;Histone Acetyltransferase p300 Inhibitor, C646 - Calbiochem
- CBNumber:
- CB62535667
- Molecular Formula:
- C24H19N3O6
- Molecular Weight:
- 445.42
- MDL Number:
- MFCD01784780
- MOL File:
- 328968-36-1.mol
- MSDS File:
- SDS
Melting point | 224-226℃ |
---|---|
Boiling point | 662.6±65.0 °C(Predicted) |
Density | 1.38±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >25mg/mL |
form | powder |
pka | 4.20±0.10(Predicted) |
color | red to brown |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
InChIKey | HEKJYZZSCQBJGB-XDHOZWIPSA-N |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Hazard Codes | N |
Risk Statements | 50 |
Safety Statements | 61 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | 3 |
C 646 price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0002 | C646 ≥98% (HPLC) | 328968-36-1 | 5mg | $153 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0002 | C646 ≥98% (HPLC) | 328968-36-1 | 25mg | $614 | 2024-03-01 | Buy |
Cayman Chemical | 10549 | C646 ≥98% (mixture of isomers) | 328968-36-1 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 10549 | C646 ≥98% (mixture of isomers) | 328968-36-1 | 5mg | $105 | 2024-03-01 | Buy |
Sigma-Aldrich | 382113 | Histone Acetyltransferase p300 Inhibitor, C646 - Calbiochem | 328968-36-1 | 10mg | $57.6 | 2024-03-01 | Buy |
C 646 Chemical Properties,Uses,Production
Description
C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. C-646 enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.
Uses
C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients.
Uses
C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury.
Definition
ChEBI: A pyrazolone that is 5-methyl-4-methylene-2-(p-carboxyphenyl)-2,4-dihydro-3H-pyrazol-3-one in which the exocyclic carbon of the methylene group is attached to a 5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl group by a single bond C646 is a potent, cell permeable and selective competitive inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases.
Biochem/physiol Actions
C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-κB, p53 and MyoD that are associated with physiology, disease processes, hippocampal synaptic plasticity, spatial memory and contextual fear.
storage
Store at +4°C
References
1) Bowers et al. (2010), Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor; Chem. Biol., 17 471 2) Santer et al. (2011), Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines; Mol. Cancer Ther., 10 1644 3) Marek et al. (2011), Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300; J. Neurosci.., 31 7486 4) Min et al. (2010), Acetylation of tau inhibits its degradation and contributes to tauopathy; Neuron, 67 953
C 646 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27486 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9328 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from C 646 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-13 | C 646
328968-36-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-09 | C 646
328968-36-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2019-12-23 | 4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
328968-36-1
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
- C 646
328968-36-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- C 646
328968-36-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- 4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
328968-36-1
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co