ChemicalBook >> CAS DataBase List >>SPD-304
SPD-304
- CAS No.
- 869998-49-2
- Chemical Name:
- SPD-304
- Synonyms
- CS-2594;SPD-304;CAY10500;SPD-304 Exclusive;TNF Receptor,Tumor Necrosis Factor Receptor,inhibit,SPD-304,SPD 304,SPD304,Inhibitor,TNFR;6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;6,7-Dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-3-indolyl]methyl]amino]ethyl]amino]methyl]-4H-chromen-4-one;4H-1-Benzopyran-4-one, 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-
- CBNumber:
- CB62592538
- Molecular Formula:
- C32H32F3N3O2
- Molecular Weight:
- 547.61
- MDL Number:
- MFCD31750784
- MOL File:
- 869998-49-2.mol
- MSDS File:
- SDS
Last updated:2023-07-12 17:09:46
SPD-304 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S1697 | SPD304 ≥98% (HPLC), solid | 869998-49-2 | 1mg | $277 | 2024-03-01 | Buy |
| Sigma-Aldrich | S1697 | SPD304 ≥98% (HPLC), solid | 869998-49-2 | 5mg | $974 | 2024-03-01 | Buy |
| Cayman Chemical | 10008012 | SPD-304 ≥98% | 869998-49-2 | 500μg | $30 | 2024-03-01 | Buy |
| Cayman Chemical | 10008012 | SPD-304 ≥98% | 869998-49-2 | 1mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 10008012 | SPD-304 ≥98% | 869998-49-2 | 5mg | $225 | 2024-03-01 | Buy |
SPD-304 Chemical Properties,Uses,Production
Uses
SPD304 has been used in the inhibition of tumor necrosis factor receptor 1 (TNFR1) in dorsal root ganglion neurons and tumor necrosis factor alpha in colonic epithelial cell lines.
Biochem/physiol Actions
SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM.
SPD-304 Preparation Products And Raw materials
Raw materials
Preparation Products
SPD-304 Suppliers
Global( 65)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4664 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 |
SPD-304
CAY10500
6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one
SPD-304 Exclusive
CS-2594
4H-1-Benzopyran-4-one, 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-
TNF Receptor,Tumor Necrosis Factor Receptor,inhibit,SPD-304,SPD 304,SPD304,Inhibitor,TNFR
6,7-Dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-3-indolyl]methyl]amino]ethyl]amino]methyl]-4H-chromen-4-one
869998-49-2
C32H32F3N3O2