Maprotiline hydrochloride
- CAS No.
- 10347-81-6
- Chemical Name:
- Maprotiline hydrochloride
- Synonyms
- ba34276;Psymion;Maprolu;Deprilept;ciba34276ba;LUDIOMIL HCL;Ludiomil tab;Einecs 233-758-8;Ludiomil comprimes;ciba34276hydrochloride
- CBNumber:
- CB6297617
- Molecular Formula:
- C20H24ClN
- Molecular Weight:
- 313.86
- MDL Number:
- MFCD00079464
- MOL File:
- 10347-81-6.mol
| Melting point | 230-232°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white |
| Water Solubility | Soluble to 50mg/ml in water. Soluble in ethanol at 10mM |
| Merck | 14,5748 |
| EWG's Food Scores | 1 |
| FDA UNII | 7C8J54PVFI |
| NCI Drug Dictionary | maprotiline hydrochloride |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KJ4555000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2921490002 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): ~750, ~900 orally (Hess) | |||||||||
| NFPA 704 |
|
Maprotiline hydrochloride price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3033 | Maprotiline Hydrochloride pharmaceutical secondary standard, certified reference material | 10347-81-6 | 500MG | $173 | 2024-03-01 | Buy |
| Sigma-Aldrich | M-920 | Maprotiline hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 10347-81-6 | 1mL | $49 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1375207 | Maprotiline hydrochloride United States Pharmacopeia (USP) Reference Standard | 10347-81-6 | 200mg | $235.8 | 2024-03-01 | Buy |
| TCI Chemical | M2527 | Maprotiline Hydrochloride >98.0%(HPLC)(T) | 10347-81-6 | 1g | $76 | 2024-03-01 | Buy |
| TCI Chemical | M2527 | Maprotiline Hydrochloride >98.0%(HPLC)(T) | 10347-81-6 | 5g | $261 | 2024-03-01 | Buy |
Maprotiline hydrochloride Chemical Properties,Uses,Production
Description
Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET; Kd = 11 nM) and is selective for NET over the serotonin (5-HT) and dopamine transporters (Kds = 5,800 and 1,000 nM, respectively). Maprotiline also binds to the 5-HT receptor subtype 5-HT2A (KI = 51 nM), as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors (Kds = 2, 570, 90, and 350 nM, respectively). In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline (20 μM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide . Formulations containing maprotiline have been used in the treatment of depression and anxiety. This product is also available as an analytical reference material (Item Nos. 32702 | 33077).
Chemical Properties
Crystalline Solid
Originator
Maprotiline hydrochloride ,Mylan
Uses
estrogen, with progesterone as oral contraceptive
Uses
Antidepressant
Uses
Maprotiline Hydrochloride has also been shown to block apoptosis of spiny neurons and inhibit SLC6A2.
Definition
ChEBI: Maprotiline hydrochloride is a member of anthracenes.
Manufacturing Process
9-(3-Hydroxypropyl)anthracene was prepared by reduction of 3-(9-anthryl) propionic acid with LiAlH4. By action of thionylchloride and then methylamine the 9-(3-hydroxypropyl)anthracene was converted to 9-(3-methylaminopropyl) anthracene. By addition of ethylene to 9-(3-methylaminopropyl)anthracene (at 150°C, a pressure of ethylene 50 atm, 24 hours) was obtained 3-(9,10- dihydro-9,10-ethanoanthracene-9-yl)-N-methylpropylamine. Hydrochloride 3- (9,10-dihydro-9,10-ethanoanthracene-9-yl)-N-methylpropylamine may be prepared by action hydrochloric acid.
Therapeutic Function
Antidepressant
General Description
Maprotiline hydrochloride, N-methyl-9,10-ethanoanthracene-9(10H)-propanamine hydrochloride (Ludiomil), is sometimesdescribed as a tetracyclic rather than a tricyclic antidepressant.The description is chemically accurate, but the compound,nonetheless, conforms to the overall TCA pharmacophore. Itis a dibenzobicyclooctadiene and can be viewed as a TCAwith an ethylene-bridged central ring. The compound is notstrongly anticholinergic and has stimulant properties. It canhave effects on the cardiovascular system. It is a SNERI.
Biological Activity
Selective noradrenalin re-uptake inhibitor.
Maprotiline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 305 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27945 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
View Lastest Price from Maprotiline hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-12 | Maprotiline Hydrochloride
10347-81-6
|
US $0.00-0.00 / kg | 1kg | 98% HPLC | 1000kg | shandong perfect biotechnology co.ltd | |
 |
2024-01-18 | Maprotiline Hydrochloride
10347-81-6
|
US $30.00 / kg | 1kg | 99% | 6000 | Xiamen Wonderful Bio Technology Co., Ltd. | |
 |
2021-11-02 | Maprotiline hydrochloride
10347-81-6
|
US $71.40-365.10 / g | 1g | 99% | 500g | Baoji Guokang Healthchem co.,ltd |
-
- Maprotiline Hydrochloride
10347-81-6
- US $0.00-0.00 / kg
- 98% HPLC
- shandong perfect biotechnology co.ltd
-
- Maprotiline Hydrochloride
10347-81-6
- US $30.00 / kg
- 99%
- Xiamen Wonderful Bio Technology Co., Ltd.
-
- Maprotiline hydrochloride
10347-81-6
- US $71.40-365.10 / g
- 99%
- Baoji Guokang Healthchem co.,ltd
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