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GSK864

GSK864 Structure
GSK864 structure
CAS No.
1816331-66-4
Chemical Name:
GSK864
Synonyms
GSK864;GSK864,GSK-864;GSK864 >=98% (HPLC);1H-Pyrazolo[4,3-c]pyridine-3,7-dicarboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7S)-
CBNumber:
CB63171695
Molecular Formula:
C30H31FN6O4
Molecular Weight:
558.6
MDL Number:
MFCD30478507
MOL File:
1816331-66-4.mol
MSDS File:
SDS
Last updated:2023-07-14 17:30:31
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GSK864 Properties

Boiling point 782.9±60.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF:20.0(Max Conc. mg/mL);35.8(Max Conc. mM)
DMSO:60.0(Max Conc. mg/mL);107.41(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);35.8(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.9(Max Conc. mM)
pka 11.73±0.70(Predicted)
form powder
color white to beige
optical activity [α]/D -66 to -76°, c = 0.5 in methanol

GSK864 price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1757 GSK864 ≥98% (HPLC) 1816331-66-4 5MG $312 2023-06-20 Buy
Sigma-Aldrich SML1757 GSK864 ≥98% (HPLC) 1816331-66-4 25MG $1210 2023-06-20 Buy
Cayman Chemical 18762 GSK864 ≥98% 1816331-66-4 500μg $37 2024-03-01 Buy
Cayman Chemical 18762 GSK864 ≥98% 1816331-66-4 1mg $65 2024-03-01 Buy
Cayman Chemical 18762 GSK864 ≥98% 1816331-66-4 5mg $266 2024-03-01 Buy
Product number Packaging Price Buy
SML1757 5MG $312 Buy
SML1757 25MG $1210 Buy
18762 500μg $37 Buy
18762 1mg $65 Buy
18762 5mg $266 Buy

GSK864 Chemical Properties,Uses,Production

Biochem/physiol Actions

GSK864 is a cell penetrant, potent and selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) that potently inhibits intracellular 2-hydroxyglutarate (2-HG) production in HT-1080 cells. It appears that GSK864 binds to an allosteric binding site and locks WT and mutant IDH1s in a catalytically inactive conformation. GSK864 is a highly bioavailable analog of GSK321. For full characterization details, please visit the GSK864 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

GSK864 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK864 Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4664 58
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
MedChemexpress LLC 58
Sigma-Aldrich 80

1816331-66-4(GSK864)Related Search:

GSK2837808A GSK6853 GSK-A1 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide GSK484
GSK J4 HCl GSK 2334470 GSK2982772 GSK2636771 Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-
GSK778 N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide GSK 2033 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide
GSK-2256098 GSK215

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GSK864 1H-Pyrazolo[4,3-c]pyridine-3,7-dicarboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7S)- GSK864 >=98% (HPLC) GSK864,GSK-864 1816331-66-4 C30H31FN6O4