ChemicalBook >> CAS DataBase List >>Difamilast
Difamilast
- CAS No.
- 937782-05-3
- Chemical Name:
- Difamilast
- Synonyms
- OPA15406);Difamilast;Difamilast (OPA-15406;Difamilast 937782-05-3;N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide;N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide;Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-;Difamilast,PDE4,OPA 15406,Inhibitor,atopic,phosphodiesterase-4,OPA15406,Phosphodiesterase (PDE),OPA-15406,dermatitis,subtype,inhibit
- CBNumber:
- CB64694667
- Molecular Formula:
- C23H24F2N2O5
- Molecular Weight:
- 446.44
- MDL Number:
- MFCD32899865
- MOL File:
- 937782-05-3.mol
Last updated:2024-01-17 09:00:41
| Density | 1.223±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (223.99 mM; Need ultrasonic) |
| pka | 13.12±0.46(Predicted) |
| InChI | InChI=1S/C23H24F2N2O5/c1-4-29-18-8-6-5-7-17(18)21(28)26-12-16-13-30-22(27-16)15-9-10-19(32-23(24)25)20(11-15)31-14(2)3/h5-11,13-14,23H,4,12H2,1-3H3,(H,26,28) |
| InChIKey | VFBILHPIHUPBPZ-UHFFFAOYSA-N |
| SMILES | C(NCC1=COC(C2=CC=C(OC(F)F)C(OC(C)C)=C2)=N1)(=O)C1=CC=CC=C1OCC |
| FDA UNII | T3U32GLJ0F |
Difamilast price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0039262 | Difamilast 99.20% | 937782-05-3 | 5mg | $500 | 2021-12-16 | Buy |
| ChemScene | CS-0039262 | Difamilast 99.20% | 937782-05-3 | 10mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0039262 | Difamilast 99.20% | 937782-05-3 | 25mg | $1800 | 2021-12-16 | Buy |
| ChemScene | CS-0039262 | Difamilast 99.20% | 937782-05-3 | 50mg | $3000 | 2021-12-16 | Buy |
| ChemScene | CS-0039262 | Difamilast 99.20% | 937782-05-3 | 100mg | $4600 | 2021-12-16 | Buy |
Difamilast Chemical Properties,Uses,Production
Biological Activity
Difamilast is a novel atopic dermatitis drug candidate discovered by Otsuka that has phosphodiesterase 4 (PDE4) inhibitory activity.
in vitro
Difamilast has particularly efficient inhibition of subtype B (IC50=11.2 nM). It (OPA-15406) improves skin condition in relevant animal models of AD.
Difamilast Preparation Products And Raw materials
Raw materials
Preparation Products
Difamilast Suppliers
Global( 27)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TianRui Pharmaceutical Chemical Co., Ltd. | +86-0551-68665055 +86-+86-18616906106 | sales@trywchem.com | China | 129 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 | wuzhouding@huihecrop.com | China | 886 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Bayee Biotech (Anqing) Co., Ltd. | 0556-0556-5032306 18917961636 | wtx@bayeebio.com | China | 253 | 61 |
| Hefei TianRui Pharmaceutical Chemistry Co., Ltd. | 0551-68933033 13956024211 | trchem@163.com | China | 81 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 18088 | 64 |
| Zhengzhou HSH Science & Technology Co., Ltd. | 0371-55932928 18937192232 | 1282296214@qq.com | China | 496 | 55 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 |
Related articles
- How is Difamilast synthesised?
- Difamilast is synthesised in two steps by chemical reaction using the monobenzylated protocatechuic acid ethyl ester as a raw ....
- Jan 17，2024
Difamilast 937782-05-3
Difamilast
(OPA-15406
OPA15406)
Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-
N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide
Difamilast,PDE4,OPA 15406,Inhibitor,atopic,phosphodiesterase-4,OPA15406,Phosphodiesterase (PDE),OPA-15406,dermatitis,subtype,inhibit
Difamilast
N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide
937782-05-3
API