(+)-AEROPLYSININ-1
- CAS No.
- 28656-91-9
- Chemical Name:
- (+)-AEROPLYSININ-1
- Synonyms
- NSC-170364;AEROPLYSININ;aeroplysinini;(+)-aeroplysinini;(+)-AEROPLYSININ-1;(+)shy-Aeroplysinin-1;Aeroplysinin (Aeroplysinin-1);AEROPLYSININ, APLYSINA AEROPHOBA;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA;4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr
- CBNumber:
- CB7286568
- Molecular Formula:
- C9H9Br2NO3
- Molecular Weight:
- 338.98
- MDL Number:
- MFCD01745659
- MOL File:
- 28656-91-9.mol
(+)-AEROPLYSININ-1 price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21498 | (+)-Aeroplysinin-1 ≥95% | 28656-91-9 | 100μg | $117 | 2024-03-01 | Buy |
TRC | A325708 | (+)shy-Aeroplysinin-1 | 28656-91-9 | 250μg | $85 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0024893 | (+)-AEROPLYSININ-1 95.00% | 28656-91-9 | 5MG | $501.71 | 2021-12-16 | Buy |
(+)-AEROPLYSININ-1 Chemical Properties,Uses,Production
Description
(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.
Uses
(+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase.
Definition
ChEBI: Aeroplysinin 1 is a tertiary alcohol.
(+)-AEROPLYSININ-1 Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-AEROPLYSININ-1 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9901 | 58 | |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |