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pipacycline

CAS No.
1110-80-1
Chemical Name:
pipacycline
Synonyms
Sieromicin;Pipacicline;Mepicycline;pipacycline;Tetrasolvina;(4S)-4β-Dimethylamino-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-2-naphthacenecarboxamide;2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
CBNumber:
CB7928471
Molecular Formula:
C29H38N4O9
Molecular Weight:
586.638
MDL Number:
MFCD00864861
MOL File:
1110-80-1.mol
Last updated:2023-05-21 10:59:17

pipacycline Properties

alpha D20 -195° (c = 0.5); D20 -175° (c = 0.5 in methanol)
Boiling point 895.8±65.0 °C(Predicted)
Density 1.55±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 4.50±1.00(Predicted)
FDA UNII PQ3P6082I5

SAFETY

Risk and Safety Statements

Toxicity LD50 i.v. in white mice: 188 mg/kg (Scalvini, Delmonte)

pipacycline price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27990 Pipacycline 1110-80-1 5mg $65 2021-12-16 Buy
Cayman Chemical 27990 Pipacycline 1110-80-1 25mg $309 2021-12-16 Buy
TRC P475703 Pipacycline 1110-80-1 5mg $75 2021-12-16 Buy
American Custom Chemicals Corporation MTB0002081 PIPACYCLINE 95.00% 1110-80-1 5MG $503.13 2021-12-16 Buy
Product number Packaging Price Buy
27990 5mg $65 Buy
27990 25mg $309 Buy
P475703 5mg $75 Buy
MTB0002081 5MG $503.13 Buy

pipacycline Chemical Properties,Uses,Production

Originator

Sieromicin,Sierochimica,Italy,1962

Uses

Pipacycline is a semi-synthetic tetracycline.

Uses

Pipacycline (mepicycline) is a semi-synthetic tetracycline formed by a Mannich condensation of formaldehyde and 4-hydroxyethylpiperazine with tetracycline. The introduction of the piperazine improves bioavailability, but Mannich bases are pro-drugs, converting back to the parent compound. Pipacycline is used commercially as a salt in combination with penicillin V for parenteral use (penimepicycline). The intrinsic in vitro activity and SARs for the amide region of the tetracycline molecule have not investigated extensively. Pipacycline has not been extensively cited in the literature.

Definition

ChEBI: Tetracycline in which a hydrogen attached to the amide nitrogen is substituted by a 4-[(2-hydroxyethyl)piperazin-1-yl]methyl group.

Manufacturing Process

1.55 g p-formaldehyde were added to a solution of 7 g N-(β-hydroxyethyl)- diethylene diamine in 150 cc isopropanol and the whole was heated to 60°C for 30 minutes, to obtain complete dissolution; after cooling the solution to 40°C, 22.2 g of anhydrous tetracycline base were added as a fine powder and the reaction was allowed to proceed for 3 hours with agitation and while passing through a current of dry nitrogen; the solution was then filtered on a Buchner funnel and the filter cake was washed twice with 20 cc isopropanol; the crystalline cake was resuspended in 100 cc anhydrous ether, again filtered and washed 3 times with 50 cc anhydrous ether; finally, it was dried in vacuo and 28.6 g of product were obtained, namely a yield of 98%.
The characteristics of this product are as follows. It is a pale yellow, nonodorous, slightly bitter, crystalline powder, very soluble in water (>1.5 g/cc), soluble in methanol and formamide, slightly soluble in ethanol and isopropanol, insoluble in ether, benzene and chloroform; MP 162° to 163°C with decomposition (uncorrected).

Therapeutic Function

Antimicrobial

pipacycline Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 15)Suppliers
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Career Henan Chemica Co
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Hubei Xinyang Medical Technology Co., Ltd 15347293736 15347293736 2853117764@qq.com China 8316 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44808 58

View Lastest Price from pipacycline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
pipacycline pictures 2024-10-22 pipacycline
1110-80-1
US $8.00 / KG 1g Min98% HPLC/gc g/kg/ton Career Henan Chemica Co
  • pipacycline pictures
  • pipacycline
    1110-80-1
  • US $8.00 / KG
  • Min98% HPLC/gc
  • Career Henan Chemica Co
(4S)-4β-Dimethylamino-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Mepicycline Pipacicline Sieromicin Tetrasolvina pipacycline 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)- 1110-80-1 C29H38N4O9