1-Boc-hexahydro-1,4-diazepine
- CAS No.
- 112275-50-0
- Chemical Name:
- 1-Boc-hexahydro-1,4-diazepine
- Synonyms
- TERT-BUTYL 1,4-DIAZEPANE-1-CARBOXYLATE;1-BOC-HOMOPIPERAZINE;HPBOC;BOC-HOPIZ;BOC-HOPAZ;Boc-HomoPiz;Boc-HoPaz*HCl;Boc-HoPiz, liq.;BUTTPARK 27\08-71;BOC-HOMOPIPERAZINE
- CBNumber:
- CB8230427
- Molecular Formula:
- C10H20N2O2
- Molecular Weight:
- 200.28
- MDL Number:
- MFCD00276987
- MOL File:
- 112275-50-0.mol
| Melting point | 143.4 °C |
|---|---|
| Boiling point | 95-110 °C0.5 mm Hg(lit.) |
| Density | 1.016 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 10.45±0.20(Predicted) |
| form | Liquid |
| Specific Gravity | 1.016 |
| color | Colorless to yellow |
| Water Solubility | Not miscible or difficult to mix in water. |
| Sensitive | Air Sensitive |
| BRN | 7581789 |
| CAS DataBase Reference | 112275-50-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 2735 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1-Boc-hexahydro-1,4-diazepine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 511382 | 1-Boc-hexahydro-1,4-diazepine 98% | 112275-50-0 | 5g | $131 | 2024-03-01 | Buy |
| Alfa Aesar | L17728 | 1-Boc-homopiperazine, 98% | 112275-50-0 | 1g | $44.65 | 2024-03-01 | Buy |
| Alfa Aesar | L17728 | 1-Boc-homopiperazine, 98% | 112275-50-0 | 5g | $117.65 | 2024-03-01 | Buy |
| TRC | B656175 | 1-Boc-hexahydro-1,4-diazepine | 112275-50-0 | 2g | $105 | 2021-12-16 | Buy |
| Usbiological | 265573 | Boc-homopiperazine | 112275-50-0 | 2g | $333 | 2021-12-16 | Buy |
1-Boc-hexahydro-1,4-diazepine Chemical Properties,Uses,Production
Chemical Properties
Colorless to yellow liquid
Uses
1-Boc-homopiperazine is used in synthesis of potent anticoagulant. It is also used to produce 4-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester by reaction with 11-bromo-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline.
Uses
1-Boc-hexahydro-1,4-diazepine is a diazepine derivative used in the preparation of pharmaceutical compounds such as histamine H3-receptor antagonists and dipeptidyl peptidase IV (DPP-IV) inhibitors.
General Description
1-Boc-hexahydro-1,4-diazepine is an N-boc protected homopiperazine. Its enthalpy of vaporization at boiling point (558.15K) is 49.498kjoule/mol.
Synthesis
To a solution of di-tert-butyldicarbonate (2.201 g, 9.780 mmol) in acetic acid (9.8 mL), a solution of 1,4-diazepane (1.0 g, 9.780 mmol) in acetic acid (9.8 mL) is added at room temperature. After 24 hours, water is added and the pH is adjusted to 10 using 10% NaOH. The aqueous phase is then extracted with dichloromethane (2 x 15 mL). The organic phase is dried and the solvent is evaporated to obtain tert-butyl 1,4-diazepane-1-carboxylate (1-Boc-hexahydro-1,4-diazepine) with a yield of 90.0%.
Precautions
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. It is sensitive to air.
References
Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. Bioorganic &Medicinal Chemistry. 2004, 12 (9), 2179-2191.
Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents. Bioorganic & medicinal chemistry. 2013, 21 (7), 1628-1642.
1-Boc-hexahydro-1,4-diazepine Preparation Products And Raw materials
Raw materials
1of7
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21639 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9220 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29886 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10310 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19943 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2993 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 1-Boc-hexahydro-1,4-diazepine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-Boc-hexahydro-1,4-diazepine
112275-50-0
|
US $8.00 / kg | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- 1-Boc-hexahydro-1,4-diazepine
112275-50-0
- US $8.00 / kg
- 99%
- Career Henan Chemical Co
112275-50-0(1-Boc-hexahydro-1,4-diazepine)Related Search:
1of4