PF 04447943
- CAS No.
- 1082744-20-4
- Chemical Name:
- PF 04447943
- Synonyms
- EOS-62041;PF 4447943;PF-04447943;PF 04447943;PF 4447943;PF-4447943;PF04447943; PF 04447943;PF 04447943 - PF 4447943;PF-04447943 >=98% (HPLC);PDE9 Inhibitor, PF-04447943 - CAS 1082744-20-4 - Calbiochem;(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
- CBNumber:
- CB82645148
- Molecular Formula:
- C20H25N7O2
- Molecular Weight:
- 395.46
- MDL Number:
- MOL File:
- 1082744-20-4.mol
| Boiling point | 599.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | -20C |
| solubility | Soluble in DMSO |
| form | Off-white solid |
| pka | 7.22±0.60(Predicted) |
| FDA UNII | 7N969W8Y4O |
PF 04447943 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.38337 | PDE9 Inhibitor, PF-04447943 - CAS 1082744-20-4 - Calbiochem | 1082744-20-4 | 10mg | $246 | 2024-03-01 | Buy |
| Cayman Chemical | 24299 | PF-04447943 ≥98% | 1082744-20-4 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 24299 | PF-04447943 ≥98% | 1082744-20-4 | 5mg | $95 | 2024-03-01 | Buy |
| Cayman Chemical | 24299 | PF-04447943 ≥98% | 1082744-20-4 | 10mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 24299 | PF-04447943 ≥98% | 1082744-20-4 | 25mg | $384 | 2024-03-01 | Buy |
PF 04447943 Chemical Properties,Uses,Production
Biological Activity
pf-04447943 is a potent and selective inhibitor of pde9 [1].phosphodiesterase 9 (pde9) selectively degrades cgmp and limits the cgmp-mediated signal transduction which occurs following glutamate binding to nmda receptors. pde9 in cortex and hippocampus of rodents and humans play an important role in memory and learning [1].pf-04447943 have high affinity with ki of 2.8, 4.5 and 18 nm for human, rhesus and rat recombinant pde9 respectively and high selectivity for pde9 versus pdes1- 8 and 10 -11. in cultured hippocampal neurons, pf-04447943 (30-100 nm) significantly increased neurite outgrowth and synapse formation. also, pf-04447943 (100 nm) significantly facilitated hippocampal slice ltp evoked by a weak tetanic stimulus [1].in mice model, pf-04447943 (1 mg/kg) significantly reduced the time spent interacting with the female mouse during the second encounter 24 h later compared to the first encounter, which suggested that pf-04447943 enhanced recognition memory. while, pf-04447943 (3 or 10 mg/kg) didn’t change the interaction times for each encounter. these results suggested that pf-04447943 enhanced memory with an inverted u-shaped dose-response efficacy curve [1].
References
[1]hutson ph, finger en, magliaro bc, et al. the selective phosphodiesterase 9 (pde9) inhibitor pf-04447943(6-[(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2h-pyran-4-yl)-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents. neuropharmacology, 2011, 61(4): 665-676.
PF 04447943 Preparation Products And Raw materials
Raw materials
Preparation Products
PF 04447943 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4662 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |