GZD824
- CAS No.
- 1421783-64-3
- Chemical Name:
- GZD824
- Synonyms
- CS-1086;HQP1351;GZD824.2CH3SO3H;GZD824DIMESYLATE;Olverembatinib dimesylate;Olverembatinib Dimesylate (GZD824);GZD824 GZD824DIMESYLATE;3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide dimethanesulfonate; Benzamide, 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-, methanesulfonate;4-Methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide methanesulfonate (1:2)
- CBNumber:
- CB82677404
- Molecular Formula:
- C31H35F3N6O7S2
- Molecular Weight:
- 724.7708096
- MDL Number:
- MFCD26142656
- MOL File:
- 1421783-64-3.mol
| storage temp. | 4°C, away from moisture and light |
|---|---|
| solubility | ≥36.25 mg/mL in DMSO; ≥33.95 mg/mL in H2O with ultrasonic; ≥4.71 mg/mL in EtOH with ultrasonic |
| form | solid |
| FDA UNII | NPJ9AW8AZR |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
GZD824 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | G932000 | GZD824 | 1421783-64-3 | 5mg | $175 | 2021-12-16 | Buy |
| TRC | G932000 | GZD824 | 1421783-64-3 | 25mg | $605 | 2021-12-16 | Buy |
| ApexBio Technology | B1402 | GZD824 | 1421783-64-3 | 25mg | $360 | 2021-12-16 | Buy |
| ChemScene | CS-0020021 | GZD824(dimesylate) 99.20% | 1421783-64-3 | 10mg | $180 | 2021-12-16 | Buy |
| ApexBio Technology | B1402 | GZD824 | 1421783-64-3 | 5mg | $115 | 2021-12-16 | Buy |
GZD824 Chemical Properties,Uses,Production
Uses
GZD824 is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I). It is a COVID19-related research product.
Biological Activity
gzd824 is an orally bioavailable inhibitor of bcr-abl with ic50 values of 0.34 and 0.68 nm for bcr-ablwt and bcr-ablt315i, respectively [1].bcr-abl is a fused protein that interacts with the interleukin-3 receptorβ(c) subunit and has tyrosine kinase activity. abl activates cell cycle-related proteins and enzymes and increases cell division. bcr-abl inhibits dna repair and causes genomic instability.gzd824 is an orally bioavailable bcr-abl inhibitor. gzd824 exhibited high affinity with kd values of 0.32 and 0.71 nm for bcr-ablwt and bcr-ablt315i, respectively. gzd824 inhibited bcr-abl with ic50 values of 0.34, 0.68, 0.27, 0.71, 0.15, 0.35, 0.29 and 0.35 nm for bcr-ablwt, bcr-ablt315i, bcr-able255k, bcr-ablg250e, bcr-ablq252h, bcr-ablh396p, bcr-ablm351t and bcr-ably253f, respectively. in a competitive binding assay, gzd824 bound to the atp-binding sites of native abl with kd values of 0.32 and 0.34 nm for non-phosphorylated and phosphorylated abl. in stably transformed ba/f3 cells, gzd824 potently inhibited cells growth with ic50 values of 1.0 and 7.1 nm for bcr-ablwt and bcr-ablt315i expressed cells, respectively [1].in mouse xenograft tumor models, gzd824 inhibited tumor growth. in mice bearing an allograft leukemia model, gzd824 significantly increased survival [1].
References
ren x, pan x, zhang z, et al. identification of gzd824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-abelson (bcr-abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib. j med chem, 2013, 56(3): 879-894.
GZD824 Preparation Products And Raw materials
Raw materials
Preparation Products
GZD824 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27894 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from GZD824 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![Benzamide, 4-?methyl-?N-?[4-?[(4-?methyl-?1-?piperazinyl)?methyl]?-?3-?(trifluoromethyl)?phenyl]?-?3-?[2-?(1H-?pyrazolo[3,?4-?b]?pyridin-?5-?yl)?ethynyl]?-?, methanesulfonate pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/6071f2ba-f93d-486f-9cdb-74f52151c90f.png) |
2019-12-24 | Benzamide, 4-?methyl-?N-?[4-?[(4-?methyl-?1-?piperazinyl)?methyl]?-?3-?(trifluoromethyl)?phenyl]?-?3-?[2-?(1H-?pyrazolo[3,?4-?b]?pyridin-?5-?yl)?ethynyl]?-?, methanesulfonate
1421783-64-3
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
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- Benzamide, 4-?methyl-?N-?[4-?[(4-?methyl-?1-?piperazinyl)?methyl]?-?3-?(trifluoromethyl)?phenyl]?-?3-?[2-?(1H-?pyrazolo[3,?4-?b]?pyridin-?5-?yl)?ethynyl]?-?, methanesulfonate
1421783-64-3
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co