PPACK, DIHYDROCHLORIDE
- CAS No.
- 142036-63-3
- Chemical Name:
- PPACK, DIHYDROCHLORIDE
- Synonyms
- PPACK, DiHCl;D-Phe-Pro-Arg-CMK.HCl;PPACK TRIFLUOROACETATE;PPACK, DIHYDROCHLORIDE;H-D-PHE-PRO-ARG-CMK 2HCL;PPACK, DIHYDROCHLORIDE USP/EP/BP;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TFA;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE 2HCL;PPACK DIHYDROCHLORIDE[D-PHE-PRO-ARG-CHLOROMETHYLKETONE, HCL]
- CBNumber:
- CB8280442
- Molecular Formula:
- C21H32Cl2N6O3
- Molecular Weight:
- 487.43
- MDL Number:
- MFCD00037003
- MOL File:
- 142036-63-3.mol
- MSDS File:
- SDS
PPACK, DIHYDROCHLORIDE price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 520222 | PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem | 142036-63-3 | 5mg | $289 | 2024-03-01 | Buy |
Sigma-Aldrich | 520222 | PPACK, Dihydrochloride - CAS 142036-63-3 - Calbiochem | 142036-63-3 | 25mg | $964 | 2024-03-01 | Buy |
Usbiological | P5504-80 | PPACK Dihydrochloride | 142036-63-3 | 5mg | $409 | 2021-12-16 | Buy |
ApexBio Technology | A2588 | PPACKDihydrochloride | 142036-63-3 | 5mg | $263 | 2021-12-16 | Buy |
PPACK, DIHYDROCHLORIDE Chemical Properties,Uses,Production
Biological Activity
ppack dihydrochloride is the dihydrochloride form of its active component ppack (d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant kivalue of 0.24 nm. ppack covalently binds to the specific active-site ser of thrombin and cross links with his57 at the binding site forming a tetrahedral ppack-thrombin complex. the complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. ppack is currently being investigated as an anti-coagulant to prevent blood coagulation. study results show that ppack is able to dose-dependently inhibit thrombin-induced platelet accumulation.jun t. liu, william paul, michael emerson, carla cicala and clive p. page. thrombin inhibitors and anti-coagulants on thrombin-induced embolization in rabbit cranial vasculature. european journal of pharmacology 264 (1994) 183-190ildiko m. kovach, paul kelley, carol eddy, frank jordan and ahmet baykal. proton bridging in the interactions of thrombin with small inhibitors. biochemistry. 2009; 48(30): 7296-7304martha e. lyon, james s. fine, paul j. henderson and andrew w. lyon. d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone (ppack): alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. clin. chem. 41/7, 1038-1041 (1995)
PPACK, DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
PPACK, DIHYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23325 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9363 | 58 |
ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 6521 | 58 |
Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 6756 | 58 |
Hubei Xinkang Pharmaceutical Chemical Co., Ltd | 027-59308705 18871579363 | 1248180077@qq.com | China | 9950 | 58 |
Hubei Chenghai Chemical Co., Ltd | 18327245847 18327245847 | 1400838877@qq.com | China | 9961 | 58 |
Hangzhou Beiputai Biopharmaceutical Co., Ltd | 0571-85350119 13305819357 | bptsales@163.com | China | 3850 | 58 |
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