ChemicalBook >> CAS DataBase List >>Sodium bis(trimethylsilyl)amide
Sodium bis(trimethylsilyl)amide
- CAS No.
- 1070-89-9
- Chemical Name:
- Sodium bis(trimethylsilyl)amide
- Synonyms
- NAHMDS;SODIUM HEXAMETHYLDISILAZANE;SODIUM HEXAMETHYLDISILAZIDE;Sodium Bis(trimethylsilyl)amide, 1M THF;HMDS Na;N-SODIOHEXAMETHYLDISILAZANE;Sodiobis(trimethylsilyl)amine;sodium bis(trimethylsilyl)amide solution;HMN NA SALT;sodiumbis(tri
- CBNumber:
- CB8382263
- Molecular Formula:
- C6H18NNaSi2
- Molecular Weight:
- 183.37
- MDL Number:
- MFCD00009835
- MOL File:
- 1070-89-9.mol
- MSDS File:
- SDS
Last updated:2024-03-25 15:20:08
| Melting point | 171-175 °C (lit.) |
|---|---|
| Boiling point | 67°C |
| Density | 0.904 g/mL at 25 °C |
| Flash point | 43 °F |
| storage temp. | 2-8°C |
| solubility | Soluble in hexane, toluene, ether,terahydrofuran, benzene and toluene. |
| form | Liquid |
| Specific Gravity | 0.9 |
| color | Clear orange to brown |
| Water Solubility | reacts |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| Sensitive | Moisture Sensitive |
| BRN | 3629917 |
| Exposure limits |
ACGIH: TWA 50 ppm; STEL 100 ppm (Skin) OSHA: TWA 200 ppm(590 mg/m3) NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) |
| CAS DataBase Reference | 1070-89-9(CAS DataBase Reference) |
| EPA Substance Registry System | Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium salt (1070-89-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C,F | |||||||||
| Risk Statements | 14-34-19-11-67-65-63-48/20-14/15-40-37 | |||||||||
| Safety Statements | 26-45-62-36/37/39-33-16-43-8 | |||||||||
| RIDADR | UN 3263 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 4.3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
Sodium bis(trimethylsilyl)amide price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 245585 | Sodium bis(trimethylsilyl)amide solution 1.0?M in THF | 1070-89-9 | 100ML | $62 | 2024-03-01 | Buy |
| Sigma-Aldrich | 80631 | Sodium bis(trimethylsilyl)amide solution produced by Wacker Chemie AG, Burghausen, Germany, 40% in THF | 1070-89-9 | 500mL | $200 | 2024-03-01 | Buy |
| Sigma-Aldrich | 245585 | Sodium bis(trimethylsilyl)amide solution 1.0?M in THF | 1070-89-9 | 800ML | $287 | 2024-03-01 | Buy |
| Sigma-Aldrich | 235083 | Sodium bis(trimethylsilyl)amide 95% | 1070-89-9 | 5g | $105 | 2023-06-20 | Buy |
| Sigma-Aldrich | 235083 | Sodium bis(trimethylsilyl)amide 95% | 1070-89-9 | 25g | $115 | 2023-06-20 | Buy |
Sodium bis(trimethylsilyl)amide Chemical Properties,Uses,Production
Chemical Properties
Slightly yellow to light beige crystalline powder
Physical properties
mp 171–175 °C; bp 170 °C/2 mmHg.
Uses
Sodium bis(trimethylsilyl)amide is a synthetically useful reagent in that it combines both high basicity and nucleophilicity, each of which may be exploited for useful organic transformations such as selective formation of enolates, preparation of Wittig reagents, formation of acyl anion equivalents, and the generation of carbenoid species. As a nucleophile, it has been used as a nitrogen source for the preparation of primary amines.It is useful as a sterically hindered base and as a nucleophile.
Uses
Significantly accelerated the polymerization of pheneylacetylene in conjunction with rhodium (I) catalysis
Uses
It is a strong base; deprotonates ketones and esters to generate enolate derivative.
General Description
Sodium bis(trimethylsilyl)amide solution (NaHMDS) is widely used as a strong base in organic synthesis for deprotonation reactions and base-catalyzed reactions. It is also involved in the generation of enolates, Wittig reagents and carbenes.
Purification Methods
It can be sublimed at 170o/2mm (bath temperature 220-250o) onto a cold finger, and can be recrystallised from *C6H6 (its solubility is: 10g in 100mL at 60o). It is slightly soluble in Et2O and is decomposed by H2O. [Wannagat & Niederprüm Chem Ber 94 1540 1961.]It is available commercially under N2 in Sure/Seal bottles in tetrahydrofuran (various concentrations) and at ~0.6M in toluene. [Beilstein 4 IV 4014.]
Sodium bis(trimethylsilyl)amide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 402)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 6000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18232 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 952 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15957 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
View Lastest Price from Sodium bis(trimethylsilyl)amide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-17 | Sodium bis(trimethylsilyl)amide
1070-89-9
|
US $30.00 / kg | 1kg | 99% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-05-17 | Sodium bis(trimethylsilyl)amide
1070-89-9
|
US $20.00 / Kg | 500g | 1M in THF ; 2M in THF | 500g;1kg;5kg;10kg;100kg;1000kg... | Zjartschem | |
 |
2024-01-18 | Sodium bis(trimethylsilyl)amide
1070-89-9
|
US $6.00-0.60 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- Sodium bis(trimethylsilyl)amide
1070-89-9
- US $30.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- Sodium bis(trimethylsilyl)amide
1070-89-9
- US $20.00 / Kg
- 1M in THF ; 2M in THF
- Zjartschem
-
- Sodium bis(trimethylsilyl)amide
1070-89-9
- US $6.00-0.60 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
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