ChemicalBook >> CAS DataBase List >>Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
- CAS No.
- 486460-00-8
- Chemical Name:
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
- Synonyms
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-3-((tert-Butoxycarbonyl)aMino)-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid;(3R)-N-Boc-3-amin;BOC- Butanoic Acid;Parecoxib SodiuM API;BOC-(R)-3-AMINO-4-(2;Sitagliptin Impurity 78;Sitagliptin Impurity 19
- CBNumber:
- CB8402112
- Molecular Formula:
- C15H18F3NO4
- Molecular Weight:
- 333.31
- MDL Number:
- MFCD06659147
- MOL File:
- 486460-00-8.mol
- MSDS File:
- SDS
Last updated:2024-08-21 22:41:43
| Melting point | 136-138℃ |
|---|---|
| Boiling point | 443.1±45.0 °C(Predicted) |
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 4.30±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | 2S9NWB23QS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B692330 | (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoicAcid | 486460-00-8 | 1g | $135 | 2021-12-16 | Buy |
| AK Scientific | X1035 | Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid | 486460-00-8 | 25g | $147 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB29150 | Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid | 486460-00-8 | 100g | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB29150 | Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid | 486460-00-8 | 250g | $400 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB29150 | Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid | 486460-00-8 | 10g | $40 | 2021-12-16 | Buy |
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Chemical Properties,Uses,Production
Physical Form
White to Yellow Solid
Description
Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.
Uses
(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.
Synthesis
(R)-β-tert-butoxycarbonylamino-2,4,5-trifluorophenylbutyric acid ethyl ester could used as a starting material and followed by adding Methanol and LiOHH2O as reaction reagents. Adding dichloromethane to the concentrate and adjust the pH to 2 with 2N HCl. Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid could be obtained through further purification.
Synthesis of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid from Carbamic acid, N-[(1R)-3-hydroxy-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 402)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5790 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12829 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 988 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 998 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18648 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21639 | 55 |
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- Boc-(R)-3-amino-4-(2,4,5-trifluoro-phenyl)-butyric acid is an important intermediate for sitagliptin synthesis, benefiting dia....
- Oct 13，2023
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View Lastest Price from Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-31 | Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)-butyric acid
486460-00-8
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2024-10-31 | Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8
|
US $0.00-0.00 / kg | 1kg | 98% up by HPLC | 20tons | Sinoway Industrial co., ltd. | |
 |
2024-10-11 | Saxagliptin Intermediate
486460-00-8
|
US $10.70 / kg | 10kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)-butyric acid
486460-00-8
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
-
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
486460-00-8
- US $0.00-0.00 / kg
- 98% up by HPLC
- Sinoway Industrial co., ltd.
-
- Saxagliptin Intermediate
486460-00-8
- US $10.70 / kg
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
486460-00-8(Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid)Related Search:
2-Deoxy-L-ribose
Sebacic acid
Butyraldehyde
ETHYLENE OXIDE
BOC-(S)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID
BOC-(R)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID
(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid
BOC-(R)-3-AMINO-4-(4-FLUORO-PHENYL)-BUTYRIC ACID
BOC-(R)-3-AMINO-4-(3,4-DIFLUORO-PHENYL)-BUTYRIC ACID
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
1of4
Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)-
(R)-Sitagliptin N-Boc-Acid IMpurity
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=99%
(3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
(3R)-N-(tert-Butoxycarbonyl)-3-aMino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-AMino-4-(2,4,5-trifluorophenyl)
butanoic acid (BOC acid)
[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID
(3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID
(R)-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid
Sitagliptin Intermediate 1
[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebutanoic acid
(3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BU
3(R)-tert-ButoxycarbonylaMino-4-(2,4,5-trifluoro-phenyl)-butyric acid
(3R)-3-(1,1-Dimethylethoxy carbonyl) amino]- 4-(2,4,5-trifluorophenyl) butanoic acid
Sitagliptin interMediate
(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic
(3R)-3-((1,1-DIMETHYLETHOXYCARBONYL)AMINO)-4-(2,4,5-TRIFLUROPHENYL)-BUTANOIC ACID
(R)-3-(Boc-aMino)-4-(2,4,5-trifluorophenyl)butanoic acid
4-(6-{[(tert-butoxy)carbonyl]aMino}-1,2,5-trifluorocyclohexa-2,4-dien-1-yl)butanoic acid
Parecoxib SodiuM API
Sitagliptin interMediateB
(3R)-3-{[(tert-butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid
Sitagliptin impurity 19/(R)-Sitagliptin N-Boc-Acid Impurity/(R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
Sitagliptin Impurity 19 ((R)-Sitagliptin N-Boc-Acid Impurity)
Sitagliptin Acid Boc Impurity (Impurity A)
BOC- Butanoic Acid
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENY
Sitagliptin Impurity 78
Sitagliptin N-BOC Carboxylic acid Impurity
(Tert-Butoxy)Carbonyl (R)-3-Amino-4-(2,4,5-trifluoro-phenyl)-butyric acid
Sitagliptin Impurity 19
(3R)-N-Boc-3-amin
(3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluoro phenyl)butanoic acid [Sita Acid]
Sitagliptin N-BOC Carboxylic Acid
Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-ButyricAci
SITAGLIPTIN CAS 654671-78-0 INTERMEDIATES
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ISO 9001：2015 REACH
Sitagliptin EP Impurity 15
5-TRIFLUORO-PHENYL)-BUTYRIC ACID
BOC-(R)-3-AMINO-4-(2
N-Boc Sitagliptin Acid Impurity
Sitagliptin Imp-1(sitagliptin Impurity-A)
[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-be...
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic acid
(R)-3-((tert-Butoxycarbonyl)aMino)-4-(2,4,5-trifluorophenyl)butanoic acid
(R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid
Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate
(βR)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4,5-trifluorobenzenebutanoic acid
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (Boc acid)
Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-
(3R) - N - (tert butoxycarbonyl) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid
BOC-(R-)3-Amino-4(2,4,5-triflurophenyl)Butanoic acid
Sitagliptin Impurity 19
(R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5- trifluorophenyl)butanoic acid
Boc-(R)-3-Amino-4-(2,4,5-trifluorphenyl)butanoic acid
486460-00-8