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1 NM-PP1

1 NM-PP1 structure

CAS No.: 221244-14-0

Chemical Name:: 1 NM-PP1

Synonyms: CS-920;1 NM-PP1;NM-PP1, 1-;Chebi:52309;PP1 ANALOG II;PP1 Analog II, 1NM-PP1;1NM-PP1(PP1 Analog II);MUTANT KINASES INHIBITOR II;PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem;4-AMINO-1-TERT-BUYTL-3-(1-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE

CBNumber:: CB9146400

Molecular Formula:: C20H21N5

Molecular Weight:: 331.41

MDL Number:: MFCD03425470

MOL File:: 221244-14-0.mol

MSDS File:: SDS

Last updated:2023-06-08 09:01:55

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1 NM-PP1 Properties

Melting point	175-176°C
Boiling point	545.7±45.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
pka	4.50±0.30(Predicted)
form	White solid
color	White to Beige

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS03

Signal word

Warning

Hazard statements

H315-H319-H272

Precautionary statements

P501-P220-P210-P221-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313

NFPA 704

	0
2		0

1 NM-PP1 price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	529606	InSolution PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem	221244-14-0	1mg	$172	2024-03-01	Buy
Sigma-Aldrich	529581	PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem PP1 Analog II, CAS 221244-14-0, is a cell-permeable PP1 analog that acts as a potent, reversible, selective, ATP-competitive inhibitor of mutant over wild-type kinases.	221244-14-0	1mg	$159	2024-03-01	Buy
Cayman Chemical	13330	1-NM-PP1 ≥95%	221244-14-0	1mg	$75	2024-03-01	Buy
Cayman Chemical	13330	1-NM-PP1 ≥95%	221244-14-0	5mg	$150	2024-03-01	Buy
Cayman Chemical	13330	1-NM-PP1 ≥95%	221244-14-0	10mg	$263	2024-03-01	Buy

Product number	Packaging	Price	Buy
529606	1mg	$172	Buy
529581	1mg	$159	Buy
13330	1mg	$75	Buy
13330	5mg	$150	Buy
13330	10mg	$263	Buy

1 NM-PP1 Chemical Properties,Uses,Production

Description

1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become ‘analog sensitive’ (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC₅₀ = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC₅₀ = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for Cdk2-as1 versus 29 μM for Cdk2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems.

Chemical Properties

White Cyrstalline Solid

Uses

A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase

Definition

ChEBI: 1-NM-PP1 is a pyrazolopyrimidine. It has a role as a tyrosine kinase inhibitor.

References

[1] bishop ac1, ubersax ja, petsch dt, matheos dp, gray ns, blethrow j, shimizu e, tsien jz, schultz pg, rose md, wood jl, morgan do, shokat km. a chemical switch for inhibitor-sensitive alleles of any protein kinase. nature. 2000 sep 21; 407 (6802): 395-401.

1 NM-PP1 Preparation Products And Raw materials

Raw materials

Preparation Products

1 NM-PP1 Suppliers

Global( 111)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9634	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Chemia Biotechnology（Shanghai） Co., Ltd	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58

View Lastest Price from 1 NM-PP1 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-02	1 NM-PP1 221244-14-0	US $1.00-1.00 / KG	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co

1 NM-PP1
221244-14-0
US $1.00-1.00 / KG
98%
Career Henan Chemical Co

1 NM-PP1 Spectrum

1 NM-PP1(221244-14-0)¹HNMR

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PP2 analog 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE PP1

1of4

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE 4-AMINO-1-TERT-BUYTL-3-(1-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE 1 NM-PP1 MUTANT KINASES INHIBITOR II PP1 ANALOG II 1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-tert-Butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-D]pyrimidin-4-amine Chebi:52309 PP1 Analog II, 1NM-PP1 4-Amino-1-tert-butyl-3-(1a€-naphthylmethyl)pyrazolo[3,4-d]pyrimidine 1NM-PP1(PP1 Analog II) NM-PP1, 1- PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem CS-920 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)- 1-tert-butyl-3-(naphthalen-1-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine 221244-14-0 Inhibitors Bases & Related Reagents Intermediates & Fine Chemicals Nucleotides Pharmaceuticals Tyrosine Kinase Inhibitors API