ChemicalBook >> CAS DataBase List >>Mandelic acid
Mandelic acid
- CAS No.
- 611-71-2
- Chemical Name:
- Mandelic acid
- Synonyms
- D-MANDELIC ACID;(R)-(-)-MANDELIC ACID;(R)-2-HYDROXY-2-PHENYLACETIC ACID;(R)-MANDELIC ACID;2-Hydroxy-2-phenylacetic acid;(R)-(-)-2-MANDELIC ACID;(-)-MANDELIC ACID;D-(-)-MANDELIC ACID;(-)-D-MANDELIC ACID;D-ALPHA-HYDROXYPHENYLACETIC ACID
- CBNumber:
- CB9411418
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD00064251
- MOL File:
- 611-71-2.mol
- MSDS File:
- SDS
Last updated:2024-10-31 18:15:48
| Melting point | 131-133 °C(lit.) |
|---|---|
| alpha | -150 º (c=2.5, H2O) |
| Boiling point | 214.6°C (rough estimate) |
| Density | 1.1677 (rough estimate) |
| refractive index | -153.5 ° (C=1, H2O) |
| Flash point | >190℃ |
| storage temp. | Store below +30°C. |
| solubility | 109.8g/l soluble |
| form | Crystalline Powder, Crystals or Flakes |
| pka | 3.37(at 25℃) |
| color | White to slightly yellow-beige |
| PH | 3.34(1 mM solution);2.75(10 mM solution);2.22(100 mM solution); |
| optical activity | [α]25/D 151°, c = 1 in ethanol |
| Water Solubility | It is partly soluble in water, freely soluble in isopropyl and ethyl alcohol. |
| Sensitive | Light Sensitive |
| BRN | 2691094 |
| Stability | Stable, but light sensitive. Combustible. Incompatible with strong bases, strong oxidizing agents. |
| InChIKey | IWYDHOAUDWTVEP-SSDOTTSWSA-N |
| LogP | 0.550 (est) |
| CAS DataBase Reference | 611-71-2(CAS DataBase Reference) |
| FDA UNII | PPL7YW1M9W |
| ATC code | B05CA06,J01XX06 |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)- (611-71-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 41-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-26-39-37/39 | |||||||||
| WGK Germany | 1 | |||||||||
| Hazard Note | Irritant/Light Sensitive | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29181980 | |||||||||
| Toxicity | LD50 orally in Rabbit: 5000 mg/kg | |||||||||
| NFPA 704 |
|
Mandelic acid price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.06914 | (R)-(-)-Mandelic acid for resolution of racemates for synthesis | 611-71-2 | 25g | $84.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.06914 | (R)-(-)-Mandelic acid for resolution of racemates for synthesis | 611-71-2 | 100g | $163 | 2024-03-01 | Buy |
| Sigma-Aldrich | 154210 | (R)-(?)-Mandelic acid ReagentPlus , ≥99% | 611-71-2 | 5g | $38.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 154210 | (R)-(?)-Mandelic acid ReagentPlus , ≥99% | 611-71-2 | 25g | $109 | 2024-03-01 | Buy |
| TCI Chemical | M0662 | D-(-)-Mandelic Acid >99.0%(GC)(T) | 611-71-2 | 25g | $56 | 2024-03-01 | Buy |
Mandelic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powde
Uses
(R)-(?)-Mandelic acid can be used:
- As a chiral acid in the separation of diastereomeric salts for the synthesis of chiral pyridoindole based building block.
- In the study of chiral acid selectivity of poly(3,4-ethylenedioxythiophene) (PEDOT) based chiral conducting?polymers.
Uses
(R)-(-)-Mandelic acid, is used as a antiseptic ingredient particularly against urinary tract infections.Mandelic acid and its derivatives are used to apply the dual activities as an antibacterial agent and as an antiaging agent. It is used as an intermediate for the synthesis of target molecules for other applications.
Uses
Antiseptic (urinary).
Definition
ChEBI: (R)-mandelic acid is the (R)-enantiomer of mandelic acid. It has a role as a human xenobiotic metabolite. It is a conjugate acid of a (R)-mandelate. It is an enantiomer of a (S)-mandelic acid.
Synthesis Reference(s)
The Journal of Organic Chemistry, 33, p. 2565, 1968 DOI: 10.1021/jo01270a105
Synthetic Communications, 18, p. 2141, 1988 DOI: 10.1080/00397918808068285
General Description
(R)-(-)-Mandelic acid, a chiral resolving agent, is also used as a building block to synthesize pharmaceutical drugs such as penicillin and cephalosporin. It can be synthesized from (R,S)-mandelonitrile with high yield and enantioselectivity using nitrilase enzyme.
Flammability and Explosibility
Non flammable
Purification Methods
Purify the mandelic acids by recrystallisation from H2O, *C6H6 or CHCl3. [Roger J Chem Soc 2168 1932,Jamison & Turner J Chem Soc 611 1942.] They have solubilities in H2O of ca 11% at 25o. [Banks & Davies J Chem Soc 73 1938.] The S-benzylisothiuronium salts has m 180o (from H2O) and [] D 25 (+) and (-) 57o (c20, EtOH) [El Masri et al. Biochem J 68 199 1958]. [Beilstein 10 IV 564.]
Mandelic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4R)-(9CI)
(R)-3-Amino-1-(3-(Trifluoromethyl)-5,6-Dihydro-[1,2,4] Triazolo[4,3-A]Pyrazin-7(8H)-Yl)-4-(2,4,5-Trifluorophenyl) Butan-1-One Mandelate(Sgn06M)
(R)-5-phenyl-1,3-dioxolane-2,4-dione
(R)-2-Hydroxy-2-phenylacetohydrazide
(R)-2-tert-butyl-3-Methyl-4-oxoiMidazolidin-1-iuM (R)-2-hydroxy-2-phenylacetate
1of2
Global( 747)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12829 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5858 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +8618580541567 | sales@zhswyy.com | China | 303 | 58 |
| Sigma Audley | +86-15937194204 +86-18126314766 | nova@sh-teruiop.com | China | 493 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1015 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 346 | 58 |
Related articles
- Biosynthesis of Mandelic acid
- Mandelic acid is an aromatic alpha hydroxy acid with the molecular formula C6H5CH(OH)CO2H. It is a white crystalline solid tha....
- Mar 10，2022
View Lastest Price from Mandelic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-31 | D-(-)-Mandelic acid
611-71-2
|
US $29.00 / mL | 97.15% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-31 | Mandelic acid
611-71-2
|
US $35.00 / kg | 1kg | 99% | 5000kg/Week | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-10-31 | Mandelic acid
611-71-2
|
US $6.00 / kg | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd |
-
- D-(-)-Mandelic acid
611-71-2
- US $29.00 / mL
- 97.15%
- TargetMol Chemicals Inc.
-
- Mandelic acid
611-71-2
- US $35.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Mandelic acid
611-71-2
- US $6.00 / kg
- 99%
- HebeiShuoshengImportandExportco.,Ltd
611-71-2(Mandelic acid)Related Search:
1of4
(R)-(-)-AMYGDALIC ACID
(R)-ALPHA-HYDROXYPHENYLACETIC ACID
R-(-)-ALPHA-HYDROXYPHENYLACETIC ACID
D-A-HYDROXYPHENYLACETIC ACID
D-2-HYDROXY-PHENYLACETIC ACID
D-(-)-AMYGDALIC ACID
D-AMYGDALIC ACID
D-PHENYLGLYCOLIC ACID
L-2-hydroxy-2-phenylacetic acid
D(-)-MANDELIC ACID FOR RESOLUTION &
(R)-(-)-MANDELIC ACID, 99+%
(R)-(-)-MANDELIC ACID, 98% (99% EE/GLC)
(R)-(-)-MANDELIC ACID 99%
D-(-)-α-Hydroxybenzeneacetic acid
ALPHAR-HYDROXY-BENZENEACETIC ACID
D-Mandelic acid or R-(-)Mandelic acid
Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)-
(r)-(-)-à-hydroxyphenylacetic acid
D-mandelic acid(R-mandelic acid)
(R)-alpha-Hydrophenylacetic acid
D-(-)-Mandelic acid 98%
L-2-Hydroxy-2-phenylessigsure
D-minus-mandelic acid sigma grade
[R,(-)]-α-Hydroxybenzeneacetic acid
D-()-Mandelic acid,(R)-α-Hydroxyphenylacetic acid
(R)-(-)-Mandelic acid, ChiPros\(tm, 99+% ee 99+%
)-Mandel
(R)-(-)-alpha-Hydroxyphenylacetic acid, (2R)-(-)-Hydroxy(phenyl)ethanoic acid, D-(-)-Phenylglycolic acid
(R)-Alfa-hydroxyphenylacetic acid
(R)-()-Mandel
(R)-(-)-Mandelic acid, 99% 25GR
(R)-(-)-Mandelic acid, 98% e.e.
(R)-(-)-MANDELIC ACID FOR RESOLUTION OF
(R)-2-Phenylglycolic acid
(R)-alpha-Hydroxy-benzeneacetic acid
Sertraline EP IMpurity E
(R)-(-)-alpha-Hydroxyphenylacetic acid, (2R)-(-)-2-Hydroxy-2-phenylethanoic acid, D-(-)-Phenylglycolic acid
(R)-(-)-Mandelic acid, ChiPros 99+%, ee 99+%
D-MANDELIC ACID extrapure
(2R)-2-Hydroxy-2-phenylacetic acid
(R)-a-Hydroxybenzeneacetic acid
(R)-a-Hydroxyphenylacetic acid
D-2-Phenylglycolic acid
(R)-(-)-MANDELIC ACID: CHIPROS 99%, EE 99%
2-Phenylglycolic acid
a-Hydroxy-benzeneacetic acid
alpha-Hydroxyphenylacetic acid
Hydroxy(phenyl)acetic acid
R-Mandelic acid D-Mandelic acid
(R)-mandelate
Benzeneaceticacid, a-hydroxy-, (aR)-
(R)-(-)-Mandelic acid ReagentPlus(R), >=99%
Sertraline impurity E
(R)-(-)-Mandelic acid Vetec(TM) reagent grade, 98%
(R)-(-)-mandelic
(R)-Hydroxyphenylaceticacid
(R)-Mandelic Acid,99%e.e.
RARECHEM AL BO 1446