Bepridil hydrochloride
- CAS No.
- 74764-40-2
- Chemical Name:
- Bepridil hydrochloride
- Synonyms
- angopril;Unii-4W2p15D93m;Bepridil hydrochloride;UEECHQPWQHYEDE-UHFFFAOYSA-N;Bepridil hydrochloride salt;Bepridil hydrochloride hydrate;Bepridil hydrochloride USP/EP/BP;l)-,monohydrochloride,monohydrate;1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride;N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)anilinehydrochloride
- CBNumber:
- CB9497924
- Molecular Formula:
- C24H37ClN2O2
- Molecular Weight:
- 421.01578
- MDL Number:
- MFCD00242668
- MOL File:
- 74764-40-2.mol
- MSDS File:
- SDS
| Melting point | 91 ±2° |
|---|---|
| storage temp. | Desiccate at RT |
| solubility | Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml) |
| form | powder |
| color | white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| FDA UNII | 4W2P15D93M |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H332-H334 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P271-P304+P340-P312-P261-P285-P304+P341-P342+P311-P501 |
| WGK Germany | 2 |
| RTECS | UY1162000 |
| Toxicity | LD50 in mice (mg/kg): 1955 orally, 23.5 i.v. (Mauvernay, 1978) |
Bepridil hydrochloride price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B5016 | Bepridil hydrochloride powder | 74764-40-2 | 100mg | $208 | 2022-05-15 | Buy |
| Tocris | 4117 | Bepridil hydrochloride ≥99%(HPLC) | 74764-40-2 | 50 | $106 | 2021-12-16 | Buy |
| Usbiological | 254738 | Bepridil hydrochloride | 74764-40-2 | 50mg | $339 | 2021-12-16 | Buy |
| ChemScene | CS-0013009 | Bepridil(hydrochloridehydrate) 99.70% | 74764-40-2 | 25mg | $220 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB148396 | Bepridil hydrochloride | 74764-40-2 | 100mg | $315 | 2021-12-16 | Buy |
Bepridil hydrochloride Chemical Properties,Uses,Production
Description
Bepridil (74764-40-2) is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activity against SARS-CoV-2 in vitro.2 Bepridil was also able to provide protection from Ebola virus3 and other filoviruses in a mouse model4.
Uses
antineoplastic, alkylating agent
Uses
Bepridil Hydrochloride is a calcium channel blocker. It also activates mitochondrial ATP-sensitive KATP channelsBepridil Hydrochloride is an antiarrhythmic and antihypertensive agent and used for treating atrial fibrillation.
Definition
ChEBI: The hydrochloride monohydrate of bepridril.
brand name
Bepadin (Medpointe); Vascor (Johnson & Johnson).
General Description
Bepridil hydrochloride,β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethylamine hydrochloride (Vascor), is a secondgenerationalkylamine-type channel blocker, structurallyunrelated to the dihydropyridines. Its actions are less specificthan those of the three prototypical channel blockers,verapamil, diltiazem, and nifedipine. In addition to being aCa2+ channel blocker, it inhibits sodium flow into the hearttissue and lengthens cardiac repolarization, causing bradycardia.Caution should be used if it is given to a patient withhypokalemia. Bepridil hydrochloride is used for stableangina. The drug has a half-life of 33 hours and is highlybound to protein (99%).
Hazard
Moderately toxic by ingestion.
Biochem/physiol Actions
Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na+-Ca2+ exchange; inhibits growth of brain tumor cells in vitro.
Mechanism of action
In addition to class IV effects, bepridil also shows class I effects. The substance is active against both supraventricular and ventricular arrhythmias , .
References
Hollingshead et al. (1992), A review of its pharmacological properties and therapeutic use in stable angina pectoris; Drugs, 44 835 Vatansever et al. (2021), Bepridil is potent against SARS-CoV-2 in vitro; Proc. Natl. Acad. Sci USA, 118 e2012201118 Johansen et al. (2015), A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity; Sci. Transl. Med., 7 290ra89 DeWald et al. (2018), The calcium channel blocker bepridil demonstrates efficacy in the murine model of marburg virus disease; J. Infect. Dis., 218(suppl 5) S588
Bepridil hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27894 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6010 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9984 | 60 |
View Lastest Price from Bepridil hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-07 | Bepridil hydrochloride USP/EP/BP
74764-40-2
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-12 | Bepridil hydrochloride
74764-40-2
|
US $0.00-0.00 / KG | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd |
-
- Bepridil hydrochloride USP/EP/BP
74764-40-2
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Bepridil hydrochloride
74764-40-2
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd