Chrysophanic acid
- CAS No.
- 481-74-3
- Chemical Name:
- Chrysophanic acid
- Synonyms
- CHRYSOPHANOL;RHUBARB EXTRACT;M13;Chrysophal;SEMEN CASSIAE EXTRACT;3-METHYLCHRYSAZIN;M 13;M-13;c.i.75400;NSC 37132
- CBNumber:
- CB9760903
- Molecular Formula:
- C15H10O4
- Molecular Weight:
- 254.24
- MDL Number:
- MFCD00001208
- MOL File:
- 481-74-3.mol
| Melting point | 194-198 °C |
|---|---|
| Boiling point | 357.45°C (rough estimate) |
| Density | 1.2693 (rough estimate) |
| refractive index | 1.4872 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | chloroform: soluble1% |
| pka | 6.63±0.20(Predicted) |
| form | crystalline |
| color | yellow-orange |
| Water Solubility | <0.1 g/100 mL at 18 ºC |
| λmax | 429nm(MeOH)(lit.) |
| Merck | 14,2258 |
| BRN | 1252300 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | 4.720 (est) |
| CAS DataBase Reference | 481-74-3(CAS DataBase Reference) |
| FDA UNII | N1ST8V8RR2 |
| EPA Substance Registry System | Chrysophanic acid (481-74-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB6725000 | |||||||||
| F | 8-10 | |||||||||
| HS Code | 29146990 | |||||||||
| NFPA 704 |
|
Chrysophanic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 229075 | 1,8-Dihydroxy-3-methylanthraquinone 98% | 481-74-3 | 50mg | $55.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 229075 | 1,8-Dihydroxy-3-methylanthraquinone 98% | 481-74-3 | 1g | $747 | 2024-03-01 | Buy |
| TCI Chemical | C2505 | Chrysophanic Acid >96.0%(HPLC) | 481-74-3 | 100mg | $102 | 2024-03-01 | Buy |
| Cayman Chemical | 19870 | Chrysophanol ≥98% | 481-74-3 | 50mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19870 | Chrysophanol ≥98% | 481-74-3 | 100mg | $61 | 2024-03-01 | Buy |
Chrysophanic acid Chemical Properties,Uses,Production
Description
Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities. It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 μM. Chrysophanol (5, 10, and 50 μM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; ) and inhibits LPS-induced DNA oxidation in BV-2 microglia. In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; ). Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
Chemical Properties
yellow crystalline solid or brown powder
Uses
A topical ointment used in the treatment of dermal conditions such as eczema and herpes.
Uses
antineoplastic, antibacterial
Uses
Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells 1. It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro 2.
Definition
ChEBI: A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.
Synthesis Reference(s)
Tetrahedron Letters, 20, p. 4911, 1979 DOI: 10.1016/S0040-4039(01)86747-2
General Description
Golden yellow plates or brown powder. Melting point 196°C. Slightly soluble in water. Pale yellow aqueous solutions turn red on addition of alkali. Solutions in concentrated sulfuric acid are red.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Chrysophanic acid is incompatible with strong oxidizing agents.
Fire Hazard
Flash point data for Chrysophanic acid are not available; however, Chrysophanic acid is probably combustible.
Purification Methods
Crystallise chrysophanic acid from EtOH or *benzene and has m 195.6-196.2o, after sublimation it in a vacuum. The yellow mono-acetate has m 188-190o (from MeOH or Me2CO). It forms Ni2+, Co2+ and Cu2+ complexes. [Beilstein 8 H 470, 8 I 725, 8 II 510, 8 III 3808, 8 IV 3277.]
Chrysophanic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2971 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3001 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 | yklbiotech@163.com | CHINA | 296 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
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- Mar 22，2024
View Lastest Price from Chrysophanic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-20 | Chrysophanic acid
481-74-3
|
US $0.00-0.00 / kg | 1kg | 0.99 | 50000kg | Hebei Kingfiner Technology Development Co.Ltd | |
 |
2024-04-28 | Coniferyl ferulate
481-74-3
|
US $0.00-0.00 / g | 1g | 98% | 2000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2023-02-24 | Chrysophanol
481-74-3
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Chrysophanic acid
481-74-3
- US $0.00-0.00 / kg
- 0.99
- Hebei Kingfiner Technology Development Co.Ltd
-
- Coniferyl ferulate
481-74-3
- US $0.00-0.00 / g
- 98%
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Chrysophanol
481-74-3
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.