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2-Chlorotrityl chloride

2-Chlorotrityl chloride Structure
2-Chlorotrityl chloride structure
CAS No.
42074-68-0
Chemical Name:
2-Chlorotrityl chloride
Synonyms
2-CHLOROTRITYL CHLORIDE RESIN;CTC resin;2-CHLOROTRITYL RESIN;2-CHLOROTRITYLCHLORIDE POLYMER RESIN;2CTC Resin;2-CHLOROPHENYLDIPHENYLMETHYL CHLORIDE;CL-TRT(2-CL)-RESIN;1-chloro-2-(chlorodiphenylmethyl)benzene;(chloro(2-chlorophenyl)Methylene)dibenzene;BR-1060
CBNumber:
CB9853612
Molecular Formula:
C19H14Cl2
Molecular Weight:
313.22
MDL Number:
MFCD00040399
MOL File:
42074-68-0.mol
MSDS File:
SDS
Last updated:2023-12-25 17:47:29
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2-Chlorotrityl chloride Properties

Melting point 130-135 °C
Boiling point 421.3±40.0 °C(Predicted)
Density 1.222±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in Chloroform, methanol and dichloromethane, insoluble in water
form Powder
color Pale yellow crystalline powder
BRN 1983914
CAS DataBase Reference 42074-68-0(CAS DataBase Reference)
FDA UNII GG3RF829XL

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Warning
Hazard statements  H290-H315-H319-H335
Precautionary statements  P234-P261-P264-P271-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-24/25-22
RIDADR  3261
WGK Germany  3
F  10-21
HS Code  2903 99 80
HazardClass  8
PackingGroup  III
NFPA 704
1
0 0

2-Chlorotrityl chloride price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.51061 2-Chlorotrityl chloride Novabiochem? 42074-68-0 25g $219 2024-03-01 Buy
Sigma-Aldrich 26569 2-Chlorotrityl chloride ≥97.0% (AT) 42074-68-0 10g $320 2024-03-01 Buy
TCI Chemical D2504 2-Chlorotrityl Chloride >98.0%(HPLC) 42074-68-0 25g $147 2024-03-01 Buy
Alfa Aesar 044407 2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 100-200 mesh, 1.0-1.4 mmol/g 42074-68-0 2g $78.65 2024-03-01 Buy
Alfa Aesar 044407 2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 100-200 mesh, 1.0-1.4 mmol/g 42074-68-0 10g $326 2024-03-01 Buy
Product number Packaging Price Buy
8.51061 25g $219 Buy
26569 10g $320 Buy
D2504 25g $147 Buy
044407 2g $78.65 Buy
044407 10g $326 Buy

2-Chlorotrityl chloride Chemical Properties,Uses,Production

Chemical Properties

off-white to yellow or brown beads

Uses

2-Chlorotrityl chloride is used as an intermediate of clotrimazole. It is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase. In addition, it serves as a protecting group reagent for carboxylic acids forming esters.

Application

2-Chlorotrityl Chloride is used in convergent peptide synthesis. Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.

Preparation

2-Chlorotrityl chloride synthesis: It is esterified with 2-Chlorobenzoic acid and ethanol in the presence of sulfuric acid or p-toluenesulfonic acid to generate Ethyl 2-Chlorobenzoate, which is then condensed with phenylmagnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl)diphenylmethanol magnesium salt is hydrolyzed with sulfuric acid to obtain (2-Chlorophenyl)diphenylmethanol, which is then chlorinated with thionyl chloride to obtain the product.

Biotechnological Applications

The 2-chlorotrityl chloride (2-CTC) resin is one of the most frequently used and most versatile resins for the large-scale manufacture of peptides. It is slightly less acid-labile than Trityl Resin and thus more widely used in solid phase peptide synthesis. Peptides UBI-8 and UBI-9 were synthesized by Fmoc-solid phase chemistry using a 2-chlorotrityl chloride linker-resin. Trityl linkers have certain advantages in comparison to the alkoxybenzyl alcohol (eg. Wang resin), especially in the area of peptide chemistry. First, the problem of racemization during the loading of the first amino acid (using DIPEA) is avoided with trityl linkers. Second, due to steric factors, no diketopiperazine formation is observed.

2-Chlorotrityl chloride synthesis

610-96-8
42074-68-0
Synthesis of 2-Chlorotrityl chloride from Methyl 2-chlorobenzoate

2-Chlorotrityl chloride Preparation Products And Raw materials

Raw materials

Ethyl 2-Chlorobenzoate Bromobenzene 2-Chlorobenzoic acid PARA TOLUENE MAGNESIUM METHOXIDE
Benzhydrol Thionyl chloride CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Methyl 2-chlorobenzoate 2-Chlorobenzotrichloride

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Preparation Products

Clotrimazole

2-Chlorotrityl chloride Suppliers

Global( 342)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Zhanyao Biotechnology Co. Ltd
15369953316 +8615369953316 admin@zhanyaobio.com China 2136 58
Chemtour Biotech Co., Ltd
+8617327281506 market@chemtour.com China 1472 58
Shanghai Qyubiotech Co., Ltd. 		+86-086-021-37596619 +8618019359838 info@qyubiotech.com China 300 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 18229 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21689 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Supplier Advantage
Hebei Zhanyao Biotechnology Co. Ltd
58
Chemtour Biotech Co., Ltd
58
Shanghai Qyubiotech Co., Ltd. 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58

View Lastest Price from 2-Chlorotrityl chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chlorotrityl chloride pictures 2024-05-20 2-Chlorotrityl chloride
42074-68-0
 US $0.00-0.00 / kg 1kg 99%+ 10000kgs per Month Shanghai Qyubiotech Co., Ltd.
2-CHLOROTRITYL CHLORIDE pictures 2024-05-17 2-CHLOROTRITYL CHLORIDE
42074-68-0
 US $16.00-6.00 / kg 1kg 99% 300tons Hebei Dangtong Import and export Co LTD
2-CHLOROTRITYL CHLORIDE pictures 2024-05-16 2-CHLOROTRITYL CHLORIDE
42074-68-0
 US $0.00 / Kg/Drum 25KG 99.5% 100 tons Ningxia Jinhua Chemical Co.,Ltd

42074-68-0(2-Chlorotrityl chloride)Related Search:

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Diphenyl-2-chlorophenylMethyl Chloride o-ChlorotriphenylchloroMethane Chloro(2-chlorophenyl)diphenylmethane (2-Chlorophenyl)diphenylmethyl Chloride ClotriMazole IMpurity C 2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 1.0 to 1.4 mmol/g KNORR-TRT(2-CL)-RESIN KNORR-2-CHLOROTRITYL RESIN KNORR 2-CT RESIN CHLORO-2-CHLOROPHENYLDIPHENYLMETHANE CHLORO(2-CHLOROPHENYL)PHENYLMETHYL POLYSTYRENE RESIN CL-TRT(2-CL) DIPHENYL-O-CHLOROPHENYLCHLOROMETHANE H-KNORR-2-CHLOROTRITYL RESIN BARLOS (2-CHLOROTRITYL CHLORIDE) RESIN BARLOS RESIN AMINO-2,4-DIMETHOXY-4'-(CARBOXYMETHYLOXY)BENZHYDRYLAMINE HANDLE LINKED TO 2-CHLOROTRITYL RESIN RINK AMIDE 2-CHLOROTRITYL RESIN RINK-BERNATOWITZ-AMIDE BARLOS RESIN RINK AMIDE BARLOS RESIN PL CL-TRT-CL RESIN NH2-SAL-TRT(2-CL)-RESIN O-CHLOROTRITYL CHLORIDE O-CHLORPHENYL-DIPHENYL-CHLOROMETHANE TRT(2-CL)-CL Chloro-(o-chlorophenyl)diphenylmethane Diphenyl(2-Chlorophenyl)Chloromethane O-CHLORPHENYL-DIPHENYL-CHLOROMETHANE(CLOTRIMAZOLE INTERMEDIATE ) 100-200mesh,1%DVB,1.0-1.6mmol/g] 2-Chlorotritylchlorideresine BARLOS-resine BR-1060 2-CHLOROPHENYL DIPHENYL CHLOROMETHANE Benzene,1-chloro-2-(chlorodiphenylMethyl)- 2-Chlorotrityl Chloride, 95.0%(T) 2-Chlorotrityl chloride, polymer-bound 200-400 mesh, extent of labeling: 1.0-1.5 mmol/g Cl loading, 1 % cross-linked 2-Chlorotriphenylmethyl chloride resin 2-Chlorotrityl chloride resin(1.0-1.2 meq/g, 200-400 mesh) 2-Chlorotrityl chloride resin(1.0-2.0 meq/g, 100-200 mesh) 2-Chlorotrityl chloride resin(1.0-1.8 meq/g, 100-200 mesh) 2-Chlorotrityl chloride resin(0.3-0.8 meq/g, 200-400 mesh) 2,4-DIMETHOXY-4'-(CARBOXYMETHYLOXY)-BENZHYDRYLAMINE HANDLE LINKED TO 2-CHLOROTRITYL RESIN 2,A-DICHLORO TRIPHENYL METHANE 2,ALPHA-DICHLOROBENZHYDRYL-POLYSTYRENE CROSSLINKED WITH DIVINYLBENZENE 2,ALPHA-DICHLOROBENZHYDRYLPOLYSTYRENE DIVINYLBENZENE COPOLYMER 2-CL-(TRT)-CL RESIN 2-CLTRT RESIN 2CT-CL RESIN 2CT-CL RESIN 100 2CT-CL RESIN 200 2-CHLOROTRIPHENYL CHLOROMETHANE 2-CHLOROTRIPHENYL CHLOROMETHANE RESIN 2-CHLOROTRITYL KNORR RESIN 2-CHLOROTRITYL CHLORIDE 2-CHLOROTRITYL CHLORIDE ON POLYSTYRENE RESIN 2-CHLOROTRITYL CHLORIDE, POLYMER-BOUND 2-CHLOROTRITYLCHLORIDE PS RESIN 2-CHLOROTRITYL CHLORIDE RESIN (50-100 MESH, 1% DVB, 1.0-1.6 MMOL/G) 2-CHLOROTRITYL CHLORIDE RESIN (100-200 MESH, 1% DVB, 1.0-1.6 MMOL/G)