グラフェニン
グラフェニン 物理性質
- 融点 :
- 170℃
- 沸点 :
- 618℃
- 比重(密度) :
- 1.428
- 屈折率 :
- 1.6800 (estimate)
- 闪点 :
- 328℃
- 貯蔵温度 :
- 2-8°C(protect from light)
- 溶解性:
- DMSO:100.0(Max Conc. mg/mL);268.24(Max Conc. mM)
- 外見 :
- 個体
- 酸解離定数(Pka):
- pKa (20°C) 7.2
- 水溶解度 :
- 38.46g/L(温度表記なし)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC320312 |
2,3-Dihydroxypropyl 2-((7-chloroquinolin-4-yl)amino)benzoate |
3820-67-5 |
1g |
￥231300 |
2021-03-23 |
購入 |
グラフェニン 化学特性,用途語,生産方法
効能
抗炎症薬
使用
Glafenine is a non-narcotic analgesic agent. Glafenine shows significant antiinflammatory activity. Glafenine is widely used for the treatment of pains of various origins.
定義
ChEBI: A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain
but high incidence of anaphylactic reactions resulted in their withdrawal from the market.
世界保健機関（WHO）
Glafenine, a quinolylanthranilate derivative, was introduced in
1965 for use as an analgesic. By the late 1970s its use had been associated with
severe allergic responses, including anaphylactoid reactions, which led to its
withdrawal in one country whereas in others a warning to this effect is required in
the product information. In 1992, on the advice of the Committee for Proprietary
Medicinal Products of the European Communities, glafenine was eventually
withdrawn worldwide by the major manufacturer.
危険性
Moderately toxic by ingestion. Human systemic
effects.
グラフェニン 上流と下流の製品情報
原材料
準備製品
グラフェニン 生産企業
Global( 67)Suppliers
3820-67-5(グラフェニン)キーワード:
- 3820-67-5
- GLAFENINE FREE BASE
- Glafeninum
- 1-glyceryl n-(7-chloro-4-quinolyl)anthranilate
- 2-[(7-Chloroquinolin-4-yl)amino]benzoic acid 2,3-dihydroxypropyl
- Alcidon
- Gilfanar
- 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate
- 2-[(7-chloro-4-quinolyl)amino]benzoic acid glyceryl ester
- 1-[N-(7-Chloro-4-quinolyl)anthranilate]glycerol
- 2,3-Dihydroxypropyl N-(7-chloro-4-quinolyl)anthranilate
- 2-[(7-Chloro-4-quinolinyl)aMino]benzoic Acid 2,3-Dihydroxypropyl Ester
- 2-[(7-Chloro-4-quinolyl)aMino]benzoic Acid α-Glyceride
- 4-[(2-Carboxyphenyl)aMino]-7-chloroquinoline α-Monoglyceride
- 4-[2-(β,γ-Dihydroxypropoxycarbonyl)phenylaMino]-7-chloroquinoline
- N-(7-Chloro-4-quinolyl)anthranilic Acid 2,3-Dihydroxypropyl Ester
- 2,3-Dihydroxypropyl-N-(7-chloro-4-quinolinyl)anthranilate
- glifanar
- glycerylaminophenaquine
- privadol
- r1707
- GLAFENINE HYDROCHLORIDE
- 1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE
- 4-((2-carboxyphenyl)amino)-7-chloroquinolinealpha-monoglyceride
- 4-(2’-(beta,gamma-dihydroxypropoxycarbonyl)phenylamino)-7-chloroquinoleine
- 4-(2’-beta,gamma-dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline
- adalgur
- alicidon
- anthranilicacid,n-(7-chloro-4-quinolyl)-,2,3-dihydroxypropylester
- benzoicacid,2-((7-chloro-4-quinolinyl)amino)-,2,3-dihydroxypropylester
- dolomate
- 2-[(7-クロロキノリン-4-イル)アミノ]安息香酸2,3-ジヒドロキシプロピル
- アリシドン
- 4-[2-(2,3-ジヒドロキシプロポキシカルボニル)フェニルアミノ]-7-クロロキノリン
- ギルファナール
- ドロマート
- グラフェニン
- o-(7-クロロキノリン-4-イルアミノ)安息香酸2,3-ジヒドロキシプロピル
- グリファナン
- グリカファン
- 2-[(7-クロロ-4-キノリニル)アミノ]安息香酸2,3-ジヒドロキシプロピル
- グラフェニン (JAN)
- 2,3-ジヒドロキシプロピル 2-[(7-クロロキノリン-4-イル)アミノ]ベンゾアート
- 鎮痛薬