ポリグリコール酸 化学特性,用途語,生産方法
解説
ポリグリコール酸は，生分解性プラスチックの一。グリコール酸の環状二量体が開環重合を繰り返すことで得られる。柔軟で生体適合性が高い医用高分子として知られ、吸収性縫合糸や硬膜補強材などに用いられる。ポリグリコリド。PGA（polyglycolic acid）。
小学館 デジタル大辞泉について 情報 | 凡例
効能
手術補助 (縫合材)
化学的特性
Polyglycolic acid (PGA), also known as polyglycolide, was first reported in 1893, but it was not until 1967 that the first commercially successful patent was granted for sutures. Like polylactide, polyglycolide is synthesized from the cyclic diester. An important difference between polylactide and polyglycolide, is that polyglycolide (mp 220 C (428 F) is higher melting than poly-L-lactide (mp 170 C (338 F). Although the polymerization reaction in both cases is reversible at high temperature, melt processing of polyglycolide is more difficult because the melting temperature is close to its decomposition temperature. Unlike poly-L-lactide which is absorbed slowly, polyglycolide is absorbed within a few months post-implantation owing to greater hydrolytic susceptibility. In vitro experiments have shown the effect on degradation by enzymes, pH, annealing treatments, and gamma irradiation. Braided polyglycolide sutures undergo surprisingly rapid hydrolysis in vivo owing to cellular enzymes released during the acute inflammatory response following implantation.
使用
Surgical aid (surgical suture material).
定義
ChEBI: A polymer composed of repeating hydroxyacetic acid units.
ポリグリコール酸 上流と下流の製品情報
原材料
準備製品