トリペレンナミン 化学特性,用途語,生産方法
効能
抗アレルギー薬, H1受容体拮抗薬
化学的特性
White, bitter, crystalline powder. Solutions
are acid to litmus.Soluble in water
and alcohol; very slightly soluble in ether; practically
insoluble in chloroform and benzene; 1%
solution in water has a pH of 4.3.
使用
This drug lessens the allergic response of the organism caused by histamine. Tripelennamine
is used for allergic symptoms, rhinitis, conjunctivitis, and for allergic and anaphylactic reactions.
Synonyms of this drug are pelanin and pyribenzamine.
反応プロフィール
Tripelennamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
健康ハザード
SYMPTOMS: Symptoms of exposure to Tripelennamine may include euphoria, aplastic anemia, excitement, hallucinations, ataxia, incoordination, athetosis, convulsions, postictal depression, dry mouth, fixed dilated pupils, flushing of the face, fever, central nervous system depression, drowsiness and coma.
火災危険
Flash point data for Tripelennamine are not available. Tripelennamine is probably combustible.
安全性プロファイル
Poison by ingestion and
intraperitoneal routes. Human mutation data
reported. Has been implicated in aplastic
anemia. Used as an antdustasnine. Addicts
have added it to paregoric to make "blue
velvet," whtch can cause euphoria by
injection. When heated to decomposition it
emits toxic fumes of NOx.
代謝経路
When pyribenzamine is
incubated with rat liver microsomes, it is metabolized via N-oxide formation and
N-dealkylation which includes removal of the
dimethylamino moiety, the thiophenylmethyl moiety of
methaphenilene, and the benzyl moiety of
pyribenzamine.
トリペレンナミン 上流と下流の製品情報
原材料
準備製品