1,4-ジアゼパン-1-カルボン酸TERT-ブチル
1,4-ジアゼパン-1-カルボン酸TERT-ブチル 物理性質
- 融点 :
- 143.4 °C
- 沸点 :
- 95-110 °C0.5 mm Hg(lit.)
- 比重(密度) :
- 1.016 g/mL at 20 °C(lit.)
- 屈折率 :
- n20/D 1.471(lit.)
- 闪点 :
- >230 °F
- 貯蔵温度 :
- Keep in dark place,Sealed in dry,Room Temperature
- 酸解離定数(Pka):
- 10.45±0.20(Predicted)
- 外見 :
- 液体
- 比重:
- 1.016
- 色:
- 無色～黄色
- 水溶解度 :
- 混和しないか、水に混ざりにくい。
- Sensitive :
- Air Sensitive
- BRN :
- 7581789
- CAS データベース:
- 112275-50-0(CAS DataBase Reference)
1,4-ジアゼパン-1-カルボン酸TERT-ブチル 価格
もっと(23)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01AFAL17728 |
1-Boc-ホモピペラジン, 98%
1-Boc-homopiperazine, 98% |
112275-50-0 |
1g |
￥16750 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01AFAL17728 |
1-Boc-ホモピペラジン, 98%
1-Boc-homopiperazine, 98% |
112275-50-0 |
5g |
￥47730 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
511382 |
1-Boc-ヘキサヒドロ-1,4-ジアゼピン 98%
1-Boc-hexahydro-1,4-diazepine 98% |
112275-50-0 |
5g |
￥33700 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCB656175 |
1-Boc-ヘキサヒドロ-1,4-ジアゼピン
1-Boc-hexahydro-1,4-diazepine |
112275-50-0 |
2g |
￥43200 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01W0235-3980 |
1-BOC-ヘキサヒドロ-1,4-ジアゼピン 96+% (NMR)
1-BOC-hexahydro-1,4-diazepine 96+% (NMR) |
112275-50-0 |
5g |
￥16000 |
2024-03-01 |
購入 |
1,4-ジアゼパン-1-カルボン酸TERT-ブチル 化学特性,用途語,生産方法
外観
無色～うすい黄色、液体
化学的特性
Colorless to yellow liquid
使用
1-Boc-hexahydro-1,4-diazepine is a diazepine derivative used in the preparation of pharmaceutical compounds such as histamine H3-receptor antagonists and dipeptidyl peptidase IV (DPP-IV) inhibitors.
一般的な説明
1-Boc-hexahydro-1,4-diazepine is an
N-boc protected homopiperazine. Its enthalpy of vaporization at boiling point (558.15K) is 49.498kjoule/mol.
合成
To a solution of di-tert-butyldicarbonate (2.201 g, 9.780 mmol) in acetic acid (9.8 mL), a solution of 1,4-diazepane (1.0 g, 9.780 mmol) in acetic acid (9.8 mL) is added at room temperature. After 24 hours, water is added and the pH is adjusted to 10 using 10% NaOH. The aqueous phase is then extracted with dichloromethane (2 x 15 mL). The organic phase is dried and the solvent is evaporated to obtain tert-butyl 1,4-diazepane-1-carboxylate (1-Boc-hexahydro-1,4-diazepine) with a yield of 90.0%.
予防処置
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. It is sensitive to air.
参考文献
Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. Bioorganic &Medicinal Chemistry. 2004, 12 (9), 2179-2191.
Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents. Bioorganic & medicinal chemistry. 2013, 21 (7), 1628-1642.
1,4-ジアゼパン-1-カルボン酸TERT-ブチル 上流と下流の製品情報
原材料
準備製品
1,4-ジアゼパン-1-カルボン酸TERT-ブチル 生産企業
Global( 266)Suppliers
1,4-ジアゼパン-1-カルボン酸TERT-ブチル スペクトルデータ(1HNMR、IR)
112275-50-0(1,4-ジアゼパン-1-カルボン酸TERT-ブチル)キーワード:
- 112275-50-0
- [1,4]DIAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- 1-BOC-HEXAHYDRO-1,4-DIAZEPINE
- 1-BOC-1,4-DIAZEPANE
- TERT-BUTYL HOMOPIPERAZINE-1-CARBOXYLATE
- TERT-BUTYL 1-HOMOPIPERAZINECARBOXYLATE
- N-(T-BUTYLOXYCARBONYL)-HOMOPIPERAZINE
- N-(TERT-BUTOXYCARBONYL)HOMOPIPERAZINE
- Boc-homopiperazine≥ 98% (Assay by titration)
- Boc-HomoPiz
- BOC-HOMOPIPERAZINE
- BOC-HOPIZ
- BOC-HOPAZ
- BUTTPARK 27\08-71
- HPBOC
- 1-(TERT-BUTOXYCARBONYL)HOMOPIPERAZINE
- N-(TERT-BUTYLOXYCARBONYL)-HOMOPIPERAZINE
- 1-(tert-Butoxycarbonyl)homopiperazine~tert-Butyl hexahydro-1,4-diazepine-1-carboxylate
- Tert-butylhexahydro-1,4-diazepine-1-carboxylate
- N-TERT-BUTYL-1-HOMOPIPERAZINE CARBOXYLATE
- 1-BOC-HOMOPIPERAZINE 98%
- Boc-HoPaz*HCl
- N-(t-Butyloxycarbonyl)-homopiperazine hydrochloride
- Boc-HoPiz, liq.
- 1-Boc-homopiperazine, tert-Butyl homopiperazine-1-carboxylate
- N-Butoxycarbonylhomopiperazine
- 1-Boc-homopiperazine ,98%
- tert-butyl 1,4-diazocane-1-carboxylate
- 1-(tert-Butoxycarbonyl)homopiperazine, tert-Butyl 1,4-diazepane-1-carboxylate
- 1-BOC-hexahydro-1,4-diazepine, 98% 5GR
- 1,4-Diazepane, N1-BOC protected
- N-ブトキシカルボニルホモピペラジン
- 1,4-ジアゼパン-1-カルボン酸TERT-ブチル
- 1-BOC-ヘキサヒドロ-1,4-ジアゼピン
- 1-BOC-ホモピペラジン
- 1-Boc-ホモピペラジン, 98%
- 1-(tert-ブトキシカルボニル)ホモピペラジン