L-アラニル-L-グルタミン 化学特性,用途語,生産方法
外観
白色の結晶又は結晶性の粉末
定義
本品は、アラニン(*)とグルタミン(*)とのジペプチドである。
参照表示名称：アラニン, グルタミン
溶解性
水に溶ける。
化粧品の成分用途
エモリエント剤、保水剤
特長
エンドトキシン試験済み
説明
L-Alanyl-L-glutamine is a synthetic glutamine dipeptide that can attenuate oxidative stress in rodent models when administered at doses of 0.75-1.5 mg/kg.
In vivo, the parenteral administration of L-alanyl-L-glutamine to Swiss mice yields higher plasma glutamine levels compared to enteral administration.
In vitro, the addition of this dipeptide (50 mM) to cultures of antibody-producing CHO cells reduces apoptosis and promotes antibody production. Treatment of insulin-secreting BRIN-BD11 β-cells with L-alanyl-L-glutamine (2 mM) protects against the inflammatory effects of exposure to lipopolysaccharide-treated primary macrophages.
化学的特性
White Solid
使用
A substitute for glutamine in mammalian cell culture media; stable to heat-sterilization.L-Alanyl-L-glutamine is used as a component in pharmaceuticals, cosmetics and food products. It is a stable Gln dipeptide, which protects mice against the jejunal crypt depletion in the setting of dietary protein and fat deficiency. It provides nutritional requirements, improves intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy. It finds application in biotechnology as a component for mammalian cell culture medium. It improves pancreatic beta-cell function, maintaining the mitochondrial metabolism and stimulus-secretion coupling essential for insulin release.
定義
ChEBI: A dipeptide formed from L-alanyl and L-glutamine residues.
L-アラニル-L-グルタミン 上流と下流の製品情報
原材料
準備製品