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Olopatadine hydrochloride

Olopatadine hydrochloride 구조식 이미지

카스 번호:: 140462-76-6

상품명:: Olopatadine hydrochloride

동의어(영문):: OLOPATADINE HCL;Patanol;Olopatadin HCL;OLAPATADINE HCL;Olopatadine Hydrochlorde;Opatanol;AL-4943A;ALO4943A;OLOPATDINEHYDROCHLORIDE;Olatadine hydrochloride

CBNumber:: CB0144403

분자식:: C21H24ClNO3

포뮬러 무게:: 373.88

MOL 파일:: 140462-76-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 481

Olopatadine hydrochloride 속성

녹는점: 242-245?C

저장 조건: Inert atmosphere,Room Temperature

용해도: H2O: ≥20mg/mL

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 흰색에서 밝은 노란색

Merck: 14,6840

BCS Class: 3(CLogP), 1 (LogP)

InChI: InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;

InChIKey: HVRLZEKDTUEKQH-NOILCQHBSA-N

SMILES: C(=C1/C2=CC=CC=C2COC2C=CC(CC(=O)O)=CC/1=2)\CCN(C)C.Cl

CAS 데이터베이스: 140462-76-6(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T,N
위험 카페고리 넘버	25-50
안전지침서	45-61
유엔번호(UN No.)	UN 2811 6.1 / PGIII
WGK 독일	3
RTECS 번호	HQ4135060
HS 번호	29329990

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H301	삼키면 유독함	급성 독성 물질 - 경구	구분 3	위험		P264, P270, P301+P310, P321, P330,P405, P501
H400	수생생물에 매우 유독함	수생 환경유해성 물질 - 급성	구분 1	경고		P273, P391, P501

예방조치문구:

P273

환경으로 배출하지 마시오.

NFPA 704

	0
2		0

Olopatadine hydrochloride C화학적 특성, 용도, 생산

개요

Olopatadine hydrochloride is an ophthalmic antihistamine that inhibits release of histamine from mast cells and is a relatively selective histamine H1 antagonist. It inhibits type 1 immediate hypersensitivity reactions. Olopatadine hydrochloride is indicated in the temporary relief of itching caused by allergic conjunctivitis. H1 antagonists have an established and valued place in the symptomatic treatment of various immediate hypersensitivity reactions. In addition, the central properties of some of the series are of therapeutic value for suppressing motion sickness or for sedation.

화학적 성질

White Solid

용도

Olopatadine hydrochloride is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.[Cayman Chemical]

Olopatadine hydrochloride 준비 용품 및 원자재

원자재

Olopatadine Ethyl Ester [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide 3-((디메틸아미노)프로필)트리페닐포스포늄브로마이드 Olopatadine Isoxepac UGDFSHGFPJSALM-OCKHKDLRSA-N 클로로[3-(디메틸아미노)프로필]마그네슘 3-클로로프로필(디메틸)아민

준비 용품

(E)-올로파타딘염산염

Olopatadine hydrochloride 공급 업체

글로벌( 481)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd	+86-02223869539 +86-15560057295	trade.kilopharma@foxmail.com	China	27	58
Hebei Duling International Trade Co. LTD	+8617333973358	sales01@hbduling.cn	China	15664	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Shanghai Affida new material science and technology center	+undefined15081010295	admin@oudaxin.com	China	390	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21688	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58

Olopatadine hydrochloride 관련 검색:

Iodixanol Tacrolimus Azelastine hydrochloride Pranoprofen Olopatadine Olopatadine Methanol (E)-Olopatadine N-DesMethyl Olopatadine HCl Olopatadine N-Oxide Olopatadine Methyl Ester α-Hydroxy Olopatadine 2- hydroxyl olopatadine hydrochloride iMpurity Isoxepac Olopatadine Isopropyl ester Hydrochloride Olopatadine Carbaldehyde DISCONTINUED Olopatadine impurity Olopatadine-d3 N-Oxide Olopatadine USP RC B