3-메틸-6-니트로인다졸
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3-메틸-6-니트로인다졸 속성
- 녹는점
- 187-188°C
- 끓는 점
- 384.9±22.0 °C(Predicted)
- 밀도
- 1.437
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 11.47±0.40(Predicted)
- 색상
- 베이지부터 진한 노란색까지
- InChI
- InChI=1S/C8H7N3O2/c1-5-7-3-2-6(11(12)13)4-8(7)10-9-5/h2-4H,1H3,(H,9,10)
- InChIKey
- FUNWSYKLFDLUIZ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC([N+]([O-])=O)=C2)C(C)=N1
- CAS 데이터베이스
- 6494-19-5
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험 카페고리 넘버 | 20/21/22 | ||
|---|---|---|---|
| 안전지침서 | 24/25-36/37 | ||
| HS 번호 | 29339900 |
| 그림문자(GHS): |
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| 신호 어: | Warning | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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3-메틸-6-니트로인다졸 C화학적 특성, 용도, 생산
개요
3-Methyl-6-nitroindazole is an important organic reagent or pharmaceutical intermediate compound used in the preparation of key intermediates of pazopanib. In experimental studies, it is mostly used for solubility determination, correlation and molecular interaction analysis studies in different pure and mixed solvents. The results showed that in the temperature range of (278.15 ~ 328.15)K, the molar fraction solubility of 3-Methyl-6-nitroindazole increased with increasing temperature in both pure and mixed solvent systems, and was maximum in pure N, N-dimethylformamide and minimum in water.화학적 성질
Brown solid용도
3-Methyl-6-nitroindazole a reactant used in the preparation of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.참고 문헌
[1] Li, Wanxin et al. “3-Methyl-6-nitroindazole in some aqueous co-solvent mixtures: Solubility determination, preferential solvation and solvent effect analysis.” The Journal of Chemical Thermodynamics 34 1 (2020): 0.[2] Li Wang. “Solubility Measurement, Correlation, and Molecular Interactions of 3-Methyl-6-nitroindazole in Different Neat Solvents and Mixed Solvents from T = 278.15 to 328.15 K.” Journal of Chemical & Engineering Data 64 8 (2019): 3260–3269.
3-메틸-6-니트로인다졸 준비 용품 및 원자재
원자재
준비 용품
3-메틸-6-니트로인다졸 공급 업체
글로벌( 283)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 |
jennysun@yzqyyykj.com | China | 71 | 58 |
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 |
wangxuhui1985@126.com | China | 55 | 55 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 18219 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 |
sales@ansciepchem.com | CHINA | 4242 | 58 |
3-메틸-6-니트로인다졸 관련 검색:
메틸파라벤 메틸-1H-벤조트리아졸 아크릴산메틸 메틸 셀룰로오스 메틸알콜 쿠레톡심메틸 벤설프론 메틸 나이트로벤젠 모노나이트로톨루엔 브롬화 메틸
5-Methyl-1H-benzotriazole
1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE
METSULFURON METHYL
6-Nitroindazole
Methyl
2-Ethyl-5-nitrobenzenamine ,98%
5-Amino-2-methylbenzenesulfonamide
N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine