5-아미노셀릭일 산
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5-아미노셀릭일 산 속성
- 녹는점
- 275-280 °C (dec.) (lit.)
- 끓는 점
- 276.03°C (rough estimate)
- 밀도
- 1.3585 (rough estimate)
- 증기압
- 0Pa at 25℃
- 굴절률
- 1.5500 (estimate)
- 인화점
- 279-281°C
- 저장 조건
- 2-8°C
- 용해도
- 디메틸설폭사이드에 용해됩니다.
- 산도 계수 (pKa)
- 2.74, 5.84(at 25℃)
- 물리적 상태
- 플레이크 크리스탈
- 색상
- 미색에서 회색까지
- 수소이온지수(pH)
- 4.0-4.1 (0.8g/l, H2O, 20℃)
- pH 범위
- Non-B uorescence (3.1) to light green B uorescence (4.4)
- 수용성
- 21°C에서 <0.1g/100mL
- 분해온도
- 279-281 ºC
- Merck
- 14,5904
- BRN
- 2090421
- BCS Class
- 4
- 안정성
- 안정적인. 산, 산 무수물, 산 염화물, 클로로포르메이트, 강산화제와 호환되지 않습니다.
- 주요 응용
- Detergent, hair dyes, prevention of colorectal cancer, treating inflammatory bowel disease, autoimmune disorders, gastrointestinal inflammation, chemokine-mediated diseases, mucosal tissue disorder, sleep disorders, rectoanal tenesmus, ulcerative colitis
- InChIKey
- KBOPZPXVLCULAV-UHFFFAOYSA-N
- LogP
- 0.98 at 25℃
- CAS 데이터베이스
- 89-57-6(CAS DataBase Reference)
- NIST
- Mesalamine(89-57-6)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-52/53 | ||
| 안전지침서 | 26-36-24/25-61-37/39 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | VO1400000 | ||
| F 고인화성물질 | 8-10-23 | ||
| 자연 발화 온도 | 280 °C | ||
| TSCA | Yes | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 29225000 | ||
| 유해 물질 데이터 | 89-57-6(Hazardous Substances Data) | ||
| 독성 | LD50 orally in Rabbit: 2800 mg/kg LD50 dermal Rat > 5000 mg/kg | ||
| 기존화학 물질 | KE-01390 |
5-아미노셀릭일 산 C화학적 특성, 용도, 생산
개요
5-Aminosalicylic acid (5-ASA), also known as mesalazine or mesalamine, is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn’s disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak, non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 μM, respectively. In ionophore-stimulated colonic mucosal cells, 1 mM 5-ASA does not inhibit prostaglandin E2 (PGE2) production, but does reduce leukotriene B4 (LTB4) synthesis approx. 50%. In ionophore-stimulated human leukocytes, 400 μM 5-ASA reduces LTB4 production approximately 20%. 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 μM.화학적 성질
Off-White to pink crystals, melting point about 280 ℃ (decomposition). Soluble in hydrochloric acid, slightly soluble in hot water, and slightly bath in cold water or ethanol. In the manufacture of light-sensitive paper, azo and sulfur dyes.용도
5-Aminosalicylic acid is used in the preparation of gastrointestinal anti-inflammatory agents. It is a metabolite of sulfasalazine. It acts as a drug involved in the treatment of Crohn's disease and ulcerative colitis. Further, it is used to make dyes and light-sensitive papers.정의
ChEBI: Mesalamine is a monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position. It has a role as a non-steroidal anti-inflammatory drug. It is an aromatic amine, an amino acid, a member of phenols, a monocarboxylic acid and a monohydroxybenzoic acid. It is functionally related to a salicylic acid. It is a conjugate acid of a mesalaminate(1-).제조 방법
Preparation by reduction of m-nitrobenzoic acid with Zn dust and HCl.주요 응용
5-Aminosalicylic acid (5-ASA) has been used to synthesize 5-formyl-aminosalicylate-inulin to quantify its release during in vitro digestion and fermentation and compare the in vitro fermentation properties of the conjugated inulin to native inulin. It is also used in cell adhesion assay to study its effects on E-cadherin glycosylation and membranous turnover. This compound is used to evaluate its effects on the neutrophilic inflammation index (NII) phenotype to study the effectiveness of the high cholesterol diet-gut inflammation (HCD-GI) platform. 5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.일반 설명
Odorless white to pinkish crystals or purplish-tan powder. Aqueous solutions acidic (pH approximately 4.1 at 0.8 mg/L water) .공기와 물의 반응
Sensitive to moisture. Water insoluble.반응 프로필
5-Aminosalicylic acid is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizers.화재위험
Flash point data for 5-Aminosalicylic acid are not available; however, 5-Aminosalicylic acid is probably combustible.Safety Profile
Poison by intraperitoneal route.Moderately toxic by ingestion. Human systemic effects byingestion: hypermotility, diarrhea, dermatitis, increasedbody temperature. When heated to decomposition it emitstoxic fumes of NOx.Purification Methods
It crystallises as needles from H2O containing a little NaHSO3 to avoid aerial oxidation to the quinone-imine. The Me ester gives needles from *C6H6, m 96o, and the hydrazide has m 180-182o (from H2O). [Fallab et al. Helv Chim Acta 34 26 1951, Shavel J Amer Pharm Assoc 42 402 1953, Beilstein 14 IV 2058.]5-아미노셀릭일 산 준비 용품 및 원자재
원자재
아연
Nitro
히드로아황산 나트륨
살리실산
2-히드록시-5-니트로벤조산
물
메탄설포닐 클로라이드
티라민
탄산나트륨(경회)
수소
하이드라진, 모노수화물
Aluminium-nickel
준비 용품
Benzoic acid, 2-[[1-amino-7-[[4-[[6-amino-5-[(3-carboxy-4-hydroxyphenyl)azo]-1-hydroxy-3-sulfo-2-naphthalenyl]azo]-2-methoxyphenyl]azo]-8-hydroxy-3,6-disulfo-2-naphthalenyl]azo]-5-[[6-amino-5-[(3-carboxy-4-hydroxyphenyl)azo]-1-hydroxy-3-sul
설파살라진
METHYL5-아미노살리실레이트
BOC-3-AMINOBENZOIC ACID
OLSALAZINE
Benzoic acid, 2-[[1-amino-7-[[4-[[6-amino-5-[(3-carboxy-4-hydroxyphenyl)azo]-1-hydroxy-3-sulfo-2-naphthalenyl]azo]-2-methoxyphenyl]azo]-8-hydroxy-3,6-disulfo-2-naphthalenyl]azo]-5-[[6-amino-5-[(3-carboxy-4-hydroxyphenyl)azo]-1-hydroxy-3-sul
tetrasodium 2-[[2-amino-6-[[4-[[4-[(3-carboxylato-4-hydroxyphenyl)azo]-7-sulphonato-1-naphthyl]azo]-2,5-dimethoxyphenyl]azo]-5-hydroxy-7-sulphonato-1-naphthyl]azo]-5-nitrobenzoate
5-아미노셀릭일 산 공급 업체
글로벌( 865)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; |
sales@coreychem.com | China | 29914 | 58 |
| Zhejiang Kinso Pharmaceuticals Co., LTD. | +8619857958369 |
sales@kinsopharma.com | China | 48 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 992 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20366 | 58 |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 149 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1142 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16228 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |