오를리스타트

오를리스타트 속성

오를리스타트 MSDS

(-)-Tetrahydrolipstatin

오를리스타트 C화학적 특성, 용도, 생산

개요

Orlistat의 작용은 일반적으로 음식에서 지방의 흡수를 막음으로써 섭취하는 칼로리의 양을 줄이는 것을 의미합니다. 다른 많은 체중 감량 약물과 마찬가지로, 오를리 스타트 운동 및식이 요법과 같은 다른 생활 습관 개선과 함께 사용하기위한 것입니다. 임상 연구에 따르면이 복합제를 사용하는 사람들은 체중 감량 연대에 약물을 포함하지 않는 것보다 2-3 킬로그램 더 잃을 수 있습니다.

용도

Orlistat에 대한 바람직한 측면 중 하나는 체중 감량에 도움이 될뿐만 아니라 혈압도 합리적으로 낮추는 데 도움이된다는 것입니다. 또한이 체중 관리 약물은 라이프 스타일 변화와 동일한 방식으로 비만인 사람들에게 2 형 당뇨병의 발병을 예방한다고 알려져 있습니다.

개요

Orlistat was launched in the UK as Xenical for the long-term treatment of obesity, preferably in conjunction with a moderately reduced calorie diet. Orlistat is a tetrahydro-derivative of the natural hypolipaemic lipstatin (from Streptomyces toxyfncini) and can be obtained either by hydrogenation of lipstatine or by several different synthetic ways involving many steps from ( S ) - rnalic acid. Orlistat is a potent inhibitor of gastrointestinal lipases required for the lipolysis and digestion of dietary fat, in particular of pancreatic lipase ; as a result, it prevents the absorption of about one third of the fat contained in food and acts as an effective weight-reducing therapy. The outcomes of several clinical trials involving thousands of obese patients showed that Orlistat promotes a significant weight loss (often between 5 and 10% after one year) and improves cardiovascular risk factors such as total cholesterol, LDL/HDL ratio, blood glucose levels, insulin, blood pressure. Orlistat has minimal systemic absorption, the majority of the compound itself being recovered in the feces ; it does not affect other gastrointestinal processes, or the absorption of other rnacronutrients such as carbohydrates and proteins.

화학적 성질

Off-White Solid

용도

Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Orlistat is a specific lipase inhibitor derived from lipostatin, which is naturally produced by Streptomyces toxytricini. Lipase inhibition induced by orlistat reduces the absorption of dietary fat, thereby contributing to caloric deficit.

생물학적 활성

Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A 2 , liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G 1 /S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo .

오를리스타트 준비 용품 및 원자재

원자재

준비 용품

오를리스타트 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hong Kong Excellence Biotechnology Co., Ltd.	+86-86-18838029171 +8618126314766	ada@sh-teruiop.com	China	893	58
Jinan Jianfeng Chemical Co., Ltd	0531-88110457; +8615562555968	info@pharmachemm.com	China	225	58
Xi'an ZB Biotech Co.,Ltd	+8618591943808	sales01@xazbbio.com	China	816	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	270	58
Shanghai Aosiris new Material Technology Co., LTD	86-15139564871 +8615139564871	wrjmoon2000@163.com	China	357	58
Sigma Audley	+86-18336680971 +86-18126314766	nova@sh-teruiop.com	China	525	58
Apeloa production Co.,Limited	+86-19131931000 +86-19131931000	admin@apcl.com.cn	China	249	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	6011	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Anhui Yiao New Material Technology Co., Ltd	+86-199-55145978 +8619955145978	sales8@anhuiyiao.com	China	253	58

오를리스타트 관련 검색: