Quinine hydrochloride

Quinine hydrochloride 구조식 이미지
카스 번호:
130-89-2
상품명:
Quinine hydrochloride
동의어(영문):
QUININE HC;QUININE HCL;chinimetten;quininemuriate;quininechloride;Quinine Impurity 11;Quinine hydrochlorid;QUININE HYDROCHLORIDE;Quinine HCL & Sulfate;QUININE HCL USP/EP/BP
CBNumber:
CB2453521
분자식:
C20H25ClN2O2
포뮬러 무게:
360.88
MOL 파일:
130-89-2.mol

Quinine hydrochloride 속성

녹는점
158-160 C
밀도
1.1206 (rough estimate)
굴절률
1.5400 (estimate)
FEMA
2976 | QUININE HYDROCHLORIDE
저장 조건
under inert gas (nitrogen or Argon) at 2-8°C
용해도
DMSO(약간 용해됨), 에탄올(1g/1ml), 글리세롤(1g/7ml), 클로로포름(1g/1ml)
물리적 상태
고체
물리적 상태
단단한 모양
색상
하얀색
수용성
549.7mg/L(25℃)
InChIKey
LBSFSRMTJJPTCW-QJLYHTAINA-N
SMILES
C12C=C(C=CC=1N=CC=C2[C@@H](O)[C@]1([H])C[C@]2([H])CCN1C[C@@H]2C=C)OC.Cl |&1:10,12,15,21,r|
LogP
3.496 (est)
EPA
Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:1), (8.alpha.,9R)- (130-89-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36-24/25
유엔번호(UN No.) 1544
위험 등급 6.1(b)
포장분류 III
HS 번호 29392000
독성 cat,LDLo,intravenous,80mg/kg (80mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 327, 1927.
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Quinine hydrochloride C화학적 특성, 용도, 생산

화학적 성질

Quinine hydrochloride is a white, silky, glittering needles; odourless, effloresces when exposed to warm air. Soluble in water, very soluble in ethanol, freely soluble in chloroform, insoluble in ether. Its solutions are neutral or alkaline to litmus. It is an alkaloid derived from the bark of the cinchona tree. Quinine Hydrochloride is used as ingredient of beverages and injection medication.

용도

Quinine Hydrochloride is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.

정의

Quinine Hydrochloride is the hydrochloride of a natural substance, quinine, obtained from the bark of various species of Cinchona including Cinchona succirubra, Pavon. (red cinchona); Cinchona officinalis, Linn; Cinchona calizaya, Wenddell; Cinchona ledgeriana, Moens. It is a nature-derived bitter flavoring agent for tonic water, among other beverages.

생물학적 활성

Quinine hydrochloride is a displays antimalarial and muscle relaxant properties. Stereoisomer of quinidine; closely related to chloroquine.?

Safety Profile

Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects by intravenous route: convulsions or effect on seizure threshold, muscle contraction or spasticity, and nausea or vomiting. Mutation data reported. Used as a local anesthetic. When heated to decomposition it emits very toxic fumes of NO, and HCI. See also QUININE.

Quinine hydrochloride 준비 용품 및 원자재

원자재

준비 용품


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