Dapoxetine
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Dapoxetine 속성
- 녹는점
- 48 - 49°C
- 끓는 점
- 454.4±38.0 °C(Predicted)
- 밀도
- 1.081±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C Freezer
- 용해도
- 클로로포름(약간 용해됨), DMSO(약간 용해됨, 가열), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 8.38±0.50(Predicted)
- 색상
- 흰색에서 옅은 베이지까지
- CAS 데이터베이스
- 119356-77-3(CAS DataBase Reference)
안전
Dapoxetine C화학적 특성, 용도, 생산
용도
Dapoxetine-d7 Hydrochloride is a Labelled Dapoxetine (D185700). A selective serotonin reuptake inhibitor (SSRI).Clinical Use
Dapoxetine is a selective serotonin re-uptake inhibitor (SSRI) which has been approved in Finland and Sweden for the treatment of premature ejaculation.Dapoxetine was discovered and developed by Lilly and was licensed to Alza, a wholly-owned subsidiary of Johnson & Johnson.Synthesis
Several synthetic routes for the preparation of dapoxetine have been disclosed, all on gram scale. Based on the routes and yields, the most likely process route is described in the scheme 4. Commercially available (R)-(+)-3-chloro-1-phenyl- 1-propanol (19) was reacted with 1-naphthol in the presence of 50% aqueous sodium hydroxide in DMF to give ether 20 in 90% yield. Activation of the secondary alcohol was accomplished through treatment of 20 with methane sulfonyl chloride and triethylamine with catalytic DMAP. Upon complete conversion to the corresponding mesylate, dimethylamine was added to the reaction mixture. The addition of hydrochloric acid in ethyl acetate to the resultant crude product gave dapoxetine hydrochloride (IV) in 67% yield. Purification of this material by re-crystallization from isopropanol provided IV in 86% yield and in 99.6% ee.
Dapoxetine 준비 용품 및 원자재
원자재
준비 용품
Dapoxetine 공급 업체
글로벌( 371)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 783 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9330 | 58 |
| Shijiazhuang Tongyang Import and Export Co., LTD | 18031361688; |
admin@sjztongyang.com | China | 987 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 938 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2971 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12468 | 58 |
| Hebei Dangtong Import and export Co LTD | +8615632927689 |
admin@hbdangtong.com | China | 984 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
Dapoxetine 관련 검색:
파록세틴
Dapoxetine iMpurity
Sildenafil citrate
Tadalafil
DAPOXETINE HYDROCHLORIDE CHEMISTRY PURE 98.5% HPLC
,Dapoxetine hydrochloride
-[2-1-NAPHTHOXY)ETHYL]BENZYLAMINE / 3-(1-NAPHTHOXY)-1-PHENYL PROPYLAMINE
Proparacaine hydrochloride
Propitocaine hydrochloride
3-(1-Naphthalenyloxy)-1-phenyl-1-propanol
BenzeneMethanaMine, N,N-diMethyl-α-[2-(1-naphthalenyloxy)ethyl]-
rac N-DideMethyl Dapoxetine
(1R)-3-Chloro-1-phenyl-propan-1-ol
(S)-3-Dimethylamino-3-phenylpropanol
3-CHLORO-1-PHENYL-1-PROPANOL
(S)-3-PHENYL-BETA-ALANINOL HCL
3-AMINO-3-PHENYL-1-PROPANOL
(S)-3-Chloro-1-phenyl-1-propanol
(S)-3-Amino-3-phenylpropan-1-ol